Results 201 to 210 of about 2,996,073 (354)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Longitudinal immune profiling uncovers regulatory T cell signatures associated with the progression of COVID-19. [PDF]
Front ImmunolKossack C +11 more
europepmc +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Cellular Therapies in Transplantation - Regulatory T Cell Therapies and Virus Specific Therapies. [PDF]
Curr Transplant RepHannouneh ZA +3 more
europepmc +1 more source
T cell receptor signalling in the control of regulatory T cell differentiation and function
Nature reviews. Immunology, 2016 Ming O. Li, A. Rudensky
semanticscholar +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Regulatory T cell therapy for Sjögren's disease: From pathogenesis to targeted treatment. [PDF]
J Transl AutoimmunLim ZFS +6 more
europepmc +1 more source