Results 231 to 240 of about 2,009,353 (358)

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Novel Autologous Regulatory T-Cell Therapy Ameliorates DSS-Induced Colitis in Humanized Mice. [PDF]

Inflamm Bowel Dis
Khan MJ, Lee YJ, Lee SY, Chung H, Nguyen-Phuong T, Kim YH, Park CG, Kang YM.   +7 more
europepmc   +1 more source

An essential regulatory role for macrophage migration inhibitory factor in T-cell activation.

, 1996
Michael Bacher, Christine N. Metz, Thierry Calandra, Konstantin Mayer, Jason Chesney, Michael Lohoff, Diethard Gemsa, Thomas M. Donnelly, Richard Bucala   +8 more
openalex   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

αTIGIT-IL2 achieves tumor regression by promoting tumor-infiltrating regulatory T cell fragility in mouse models. [PDF]

Nat Commun
Wang T, Xu Y, Zhang Z, Wu Y, Chen L, Zheng X, Peng H, Zou Q, Sun R, Ma H, Sun H, Tian Z, Zheng X.   +12 more
europepmc   +1 more source

T Cell Receptor γ Gene Regulatory Sequences Prevent the Function of a Novel TCRγ/pTα Pre–T Cell Receptor

, 1998
Joonsoo Kang, Hans Jörg Fehling, Catherine Laplace, Marie Malissen, Dragana Cado, David H. Raulet   +5 more
openalex   +1 more source

Blockade of CTLA-4 Signals Inhibits Th2-Mediated Murine Chronic Graft-Versus-Host Disease by an Enhanced Expansion of Regulatory CD8+ T Cells [PDF]

, 2000
Jinkyo Sakurai, Junko Ohata, Kiyoshi Saito, Hiroaki Miyajima, T Hirano, Takao Kohsaka, Shoji ENOMOTO, Ko Okumura, Miyuki Azuma   +8 more
openalex   +1 more source

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

HuR ablation destabilizes <i>Foxp3</i> mRNA and impairs regulatory T cell function, contributing to an autoimmune phenotype. [PDF]

Front Immunol
Fattahi F, Ellis JS, Vallance L, Bahleda K, Holden J, Socha S, Meier J, Gomez-Rivera F, Atasoy U.   +8 more
europepmc   +1 more source

Human T Cell Leukemia Virus Type 1 Tax Protein Increases NF-κB Dimer Formation and Antagonizes the Inhibitory Activity of the IκBα Regulatory Protein

, 1996
Louisa Petropoulos, Rongtuan Lin, John Hiscott   +2 more
openalex   +1 more source