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Regulatory T cell function in autoimmune disease
Journal of Translational Autoimmunity, 2021 Autoimmune diseases are characterized by a failure of tolerance to own body components resulting in tissue damage. Regulatory T cells are gatekeepers of tolerance.
Anandi Rajendeeran, Klaus Tenbrock
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Frontiers in Immunology, 2018 Regulatory T cells (Tregs) are an attractive therapeutic tool for several different immune pathologies. Therapeutic Treg application often requires prolonged in vitro culture to generate sufficient Treg numbers or to optimize their functionality, e.g ...
Anna Nowak +12 more
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Frontiers in Cell and Developmental Biology, 2022 B cells are the core components of humoral immunity. A mature B cell can serve in multiple capacities, including antibody production, antigen presentation, and regulatory functions.
Diaoyi Tan +17 more
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Cell, 2000 The phenomena of T cell–mediated suppression in immunologic tolerance have been controversial and remain an exciting area of active research. An approach from the analysis of autoimmune-preventive activity of normal T cells is now revealing a unique regulatory T cell population dominantly engaged in the maintenance of immunologic self-tolerance ...
Shimon Sakaguchi
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Current Biology, 2005 First discovered… The existence of T regulatory cells was first suggested by several animal models in the 1970s. Organ-specific autoimmunity was found to be induced in specific strains of mice that had been thymectomized 3 days after birth but not after thymectomy at 0 or 7 days.
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Tissue regulatory T cells [PDF]
Immunology, 2020 SummaryFoxp3+ CD4+ regulatory T cells (Tregs) are an immune cell lineage endowed with immunosuppressive functionality in a wide array of contexts, including both anti‐pathogenic and anti‐self responses. In the past decades, our understanding of the functional diversity of circulating or lymphoid Tregs has grown exponentially.
Inchul Cho +3 more
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Combined therapy with GABA and proinsulin/alum acts synergistically to restore long-term normoglycemia by modulating T-cell autoimmunity and promoting β-cell replication in newly diabetic NOD mice. [PDF]
, 2014 Antigen-based therapies (ABTs) fail to restore normoglycemia in newly diabetic NOD mice, perhaps because too few β-cells remain by the time that ABT-induced regulatory responses arise and spread.
Chen, Zheying +4 more
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Regulatory T Cells in Asthma [PDF]
Immunity, 2009 Asthma is characterized by T helper cell 2 (Th2) type inflammation, leading to airway hyperresponsiveness and tissue remodeling. Th2 cell-driven inflammation is likely to represent an abnormal response to harmless airborne particles. These reactions are normally suppressed by regulatory T cells, which maintain airway tolerance.
Lloyd, Clare M. +1 more
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Metabolic regulation of regulatory T cell development and function [PDF]
, 2014 It is now well established that the effector T cell (Teff) response is regulated by a series of metabolic switches. Quiescent T cells predominantly require ATP-generating processes, whereas proliferating Teff require high metabolic flux through growth ...
Alves +68 more
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High glucose promotes regulatory T cell differentiation.
PLoS ONE, 2023 The consumption of processed foods and sugary sodas in Western diets correlates with an increased incidence of obesity, metabolic syndromes such as type 2 diabetes, cardiovascular diseases, and autoimmune diseases including inflammatory bowel disease and
Elise Pitmon +4 more
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