Results 21 to 30 of about 2,996,073 (354)
Current Biology, 2005 First discovered… The existence of T regulatory cells was first suggested by several animal models in the 1970s. Organ-specific autoimmunity was found to be induced in specific strains of mice that had been thymectomized 3 days after birth but not after thymectomy at 0 or 7 days.
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Current Opinion in Pharmacology, 2004 Regulatory T (TR) cells are a subset of T cells that function to control immune responses. Different populations of TR cells have been described, including thymically derived CD4(+)CD25+ TR cells and Tr1 cells induced in the periphery through exposure to antigen.
Thompson, C, Powrie, F
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Tissue regulatory T cells: regulatory chameleons
Nature Reviews Immunology, 2021 The FOXP3+CD4+ regulatory T (Treg) cells located in non-lymphoid tissues differ in phenotype and function from their lymphoid organ counterparts. Tissue Treg cells have distinct transcriptomes, T cell receptor repertoires and growth and survival factor dependencies that arm them to survive and operate in their home tissue. Their functions extend beyond
Andrés R. Muñoz-Rojas, Diane Mathis
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High glucose promotes regulatory T cell differentiation.
PLoS ONE, 2023 The consumption of processed foods and sugary sodas in Western diets correlates with an increased incidence of obesity, metabolic syndromes such as type 2 diabetes, cardiovascular diseases, and autoimmune diseases including inflammatory bowel disease and
Elise Pitmon +4 more
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Frontiers in Immunology, 2018 Background: Regulatory T (Treg) cells are necessary for the maintenance of allogenic pregnancy. However, the repertoire of effector Treg cells at the feto-maternal interface in human pregnancy remains unknown.
Sayaka Tsuda +8 more
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Cell Reports Medicine, 2021 Summary: Immune suppression by CD4+FOXP3+ regulatory T (Treg) cells and tumor infiltration by CD8+ effector T cells represent two major factors impacting response to cancer immunotherapy.
Jaime L. Chao +8 more
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Regulatory T-cell therapy approaches
Clinical and Experimental Immunology, 2022 SummaryRegulatory T cells (Tregs) have enormous therapeutic potential to treat a variety of immunopathologies characterized by aberrant immune activation. Adoptive transfer of ex vivo expanded autologous Tregs continues to progress through mid- to late-phase clinical trials in several disease spaces and has generated promising preliminary safety and ...
McCallion, O +3 more
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T cell-intrinsic role of IL-6 signaling in primary and memory responses
eLife, 2014 Innate immune recognition is critical for the induction of adaptive immune responses; however the underlying mechanisms remain incompletely understood.
Simone A Nish +14 more
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Emerging Complexity in CD4+T Lineage Programming and Its Implications in Colorectal Cancer
Frontiers in Immunology, 2021 The intestinal immune system has the difficult task of protecting a large environmentally exposed single layer of epithelium from pathogens without allowing inappropriate inflammatory responses.
Daniel DiToro +3 more
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Regulatory T-cell therapy in Crohn’s disease: challenges and advances
Gut, 2020 The prevalence of IBD is rising in the Western world. Despite an increasing repertoire of therapeutic targets, a significant proportion of patients suffer chronic morbidity.
J. Clough +4 more
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