Results 31 to 40 of about 2,009,353 (358)
Current Opinion in Pharmacology, 2004 Regulatory T (TR) cells are a subset of T cells that function to control immune responses. Different populations of TR cells have been described, including thymically derived CD4(+)CD25+ TR cells and Tr1 cells induced in the periphery through exposure to antigen.
Thompson, C, Powrie, F
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Notch/Delta signaling constrains reengineering of pro-T cells by PU.1 [PDF]
, 2006 PU.1 is essential for early stages of mouse T cell development but antagonizes it if expressed constitutively. Two separable mechanisms are involved: attenuation and diversion. Dysregulated PU.1 expression inhibits pro-T cell survival, proliferation, and
Adams, Stephanie L. +8 more
core +3 more sources
Regulatory T cells for tolerance [PDF]
Human Immunology, 2018 Regulatory T cells (Tregs) are critical mediators of immune homeostasis and hold significant promise in the quest for transplantation tolerance. Progress has now reached a critical threshold as techniques for production of clinical therapies are optimised and Phase I/II clinical trials are in full swing.
Kawai, K +4 more
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Frontiers in Immunology, 2018 Background: Regulatory T (Treg) cells are necessary for the maintenance of allogenic pregnancy. However, the repertoire of effector Treg cells at the feto-maternal interface in human pregnancy remains unknown.
Sayaka Tsuda +8 more
doaj +1 more source
Regulatory T cells induced by B cells: a novel subpopulation of regulatory T cells [PDF]
Journal of Biomedical Science, 2017 Regulatory T cells play a crucial role in the homeostasis of the immune response. In addition to CD4+Foxp3+ regulatory T cells, several subsets of Foxp3- regulatory T cells, such as T helper 3 (Th3) cells and type 1 regulatory T (Tr1) cells, have been described in mice and human.
Chien-Hui Chien, Bor-Luen Chiang
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3-hydroxykynurenine suppresses CD4+ T-cell proliferation, induces T-regulatory-cell development, and prolongs corneal allograft survival [PDF]
, 2011 Copyright © 2011 Association for Research in Vision and Ophthalmology. This article is available open access through the publisher’s website at the link below.Purpose.
Fu, Hongmei +4 more
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Emerging Complexity in CD4+T Lineage Programming and Its Implications in Colorectal Cancer
Frontiers in Immunology, 2021 The intestinal immune system has the difficult task of protecting a large environmentally exposed single layer of epithelium from pathogens without allowing inappropriate inflammatory responses.
Daniel DiToro +3 more
doaj +1 more source
VIP contribution to the decidualization program: regulatory T cell recruitment [PDF]
, 2014 During early pregnancy, the human uterus undergoes profound tissue remodeling characterized by leukocyte invasion and production of proinflammatory cytokines, followed by tissue repair and tolerance maintenance induction.
Agüero, Mariana +5 more
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T cell-intrinsic role of IL-6 signaling in primary and memory responses
eLife, 2014 Innate immune recognition is critical for the induction of adaptive immune responses; however the underlying mechanisms remain incompletely understood.
Simone A Nish +14 more
doaj +1 more source
Cell Reports Medicine, 2021 Summary: Immune suppression by CD4+FOXP3+ regulatory T (Treg) cells and tumor infiltration by CD8+ effector T cells represent two major factors impacting response to cancer immunotherapy.
Jaime L. Chao +8 more
doaj +1 more source