Results 31 to 40 of about 2,996,073 (354)
T cell epitope immunotherapy induces a CD4+ T cell population with regulatory activity. [PDF]
PLoS Medicine, 2005 BACKGROUND: Synthetic peptides, representing CD4(+) T cell epitopes, derived from the primary sequence of allergen molecules have been used to down-regulate allergic inflammation in sensitised individuals. Treatment of allergic diseases with peptides may
Adrienne Verhoef +3 more
doaj +1 more source
CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors
Nature Immunology, 2019 Depleting regulatory T cells (T reg cells) to counteract immunosuppressive features of the tumor microenvironment (TME) is an attractive strategy for cancer treatment; however, autoimmunity due to systemic impairment of their suppressive function limits ...
Haiping Wang +19 more
semanticscholar +1 more source
Tr1-like T cells- an enigmatic regulatory T cell lineage
Frontiers in Immunology, 2016 The immune system evolved to respond to foreign invaders and prevent autoimmunity to self-antigens. Several types of regulatory T cells facilitate the latter process.
Anna Malgorzata White +2 more
doaj +1 more source
Past, Present, and Future of Regulatory T Cell Therapy in Transplantation and Autoimmunity
Frontiers in Immunology, 2019 Regulatory T cells (Tregs) are important for the induction and maintenance of peripheral tolerance therefore, they are key in preventing excessive immune responses and autoimmunity. In the last decades, several reports have been focussed on understanding
M. Romano +4 more
semanticscholar +1 more source
Regulatory T Cells as Immunotherapy [PDF]
Frontiers in Immunology, 2014 Regulatory T cells (Tregs) suppress exuberant immune system activation and promote immunologic tolerance. Because Tregs modulate both innate and adaptive immunity, the biomedical community has developed an intense interest in using Tregs for immunotherapy.
Singer, Benjamin D. +2 more
openaire +3 more sources
Current Opinion in Immunology, 2001 There is now compelling evidence that CD4(+) T cells that specialize in the suppression of immune responses play a key role in the control of immune pathology. Recently, there have been a number of reports that have provided information on the generation of CD4(+) regulatory T cells in the thymus and in the periphery.
Read, S, Powrie, F
openaire +3 more sources
Frontiers in Immunology, 2023 The regulatory T (Treg) cells constitute a functionally defined subpopulation of T cells that modulate the immune system and maintain immune tolerance through suppression of the development of autoimmune responses to self-antigens and allergic reactions ...
Jefferson Russo Victor +2 more
doaj +1 more source
The Alarmin IL-33 Promotes Regulatory T Cell Function in the Intestine
Nature, 2014 FOXP3+ regulatory T cells (Treg cells) are abundant in the intestine, where they prevent dysregulated inflammatory responses to self and environmental stimuli.
Chris Schiering +15 more
semanticscholar +1 more source
Mitochondrial complex III is essential for regulatory T cell suppressive function
Nature, 2018 Regulatory T cells (Treg cells), a distinct subset of CD4+ T cells, are necessary for the maintenance of immune self-tolerance and homeostasis1,2. Recent studies have demonstrated that Treg cells exhibit a unique metabolic profile, characterized by an ...
S. Weinberg +12 more
semanticscholar +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background The delipid extracorporeal lipoprotein filter from plasma (DELP) treatment can effectively reduce blood lipid, increase blood flow, and improve neurological deficits in patients with acute ischemic stroke (AIS). However, its effect on vision and retinal microcirculation in stroke patients has never been reported.
Ning Li +9 more
wiley +1 more source