Results 251 to 260 of about 1,958,413 (325)

Immunometabolism of regulatory T cells in cancer. [PDF]

Oncogene
Saravia J, Chi H.
europepmc   +1 more source

FoxP3 Regulates T Follicular Regulatory Cell Function

, 2018
Shenda Hou
openalex   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Regulatory T Cells in Invasive Breast Cancer: Prognosis, Mechanisms and Therapy. [PDF]

Cancers (Basel)
Xu A, Ayoub S, Zhang H, Wu Y, Rau M, Ma X.   +5 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Selective disruption of lipid peroxide homeostasis in intratumoral regulatory T cells by targeting FSP1 enhances cancer immunity. [PDF]

Sci Adv
Castillo JG, Silveria S, Schirokauer L, Sauquet A, Hung J, Jaworski G, Hendricks JM, Sul HS, Olzmann JA, DuPage M.   +9 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Correction: Regulatory T cells in liver metastases: emerging and divergent roles in tumour progression. [PDF]

eGastroenterology
europepmc   +1 more source

TIM3-mediated differentiation of IL-10-producing CD25⁺ B cells by expanded regulatory T cells. [PDF]

J Mol Med (Berl)
Alhabbab RY, Mastronicola D, Lombardi G, Scottà C.   +3 more
europepmc   +1 more source