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T regulatory cells turn on T regulatory cells
Blood, 2009In this issue of Blood , Miao and colleagues demonstrate that Tregs from a FoxP3 transgenic mouse injected with a normally immunogenic FVIII plasmid not only suppress the response to FVIII but also may “turn on” host Tregs upon adoptive transfer.
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Annales de dermatologie et de venereologie, 2007
International ...
Aubin, François, Saas, Philippe
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International ...
Aubin, François, Saas, Philippe
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Regulatory T cells as therapeutic cells
Current Opinion in Organ Transplantation, 2008Although a plethora of data indicate the importance of regulatory T cells (Tregs) in experimental and clinical transplantation, are we any closer to seeing these cells as therapeutic tools in the clinic? This review discusses the functional and practical aspects of using CD4+CD25hiFoxp3+ Tregs as cellular therapeutic products in clinical ...
Sagoo, Pervinder +2 more
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2021
Mucosal surfaces are distinctive sites exposed to environmental, dietary, and microbial antigens. Particularly in the gut, the host continuously actively adapts via complex interactions between the microbiota and dietary compounds and immune and other tissue cells.
Pawel R. Kiela +2 more
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Mucosal surfaces are distinctive sites exposed to environmental, dietary, and microbial antigens. Particularly in the gut, the host continuously actively adapts via complex interactions between the microbiota and dietary compounds and immune and other tissue cells.
Pawel R. Kiela +2 more
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Annual Review of Immunology, 2020
Foxp3-expressing CD4+regulatory T (Treg) cells play key roles in the prevention of autoimmunity and the maintenance of immune homeostasis and represent a major barrier to the induction of robust antitumor immune responses. Thus, a clear understanding of the mechanisms coordinating Treg cell differentiation is crucial for understanding numerous facets ...
Peter A. Savage +2 more
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Foxp3-expressing CD4+regulatory T (Treg) cells play key roles in the prevention of autoimmunity and the maintenance of immune homeostasis and represent a major barrier to the induction of robust antitumor immune responses. Thus, a clear understanding of the mechanisms coordinating Treg cell differentiation is crucial for understanding numerous facets ...
Peter A. Savage +2 more
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Current Opinion in Organ Transplantation, 2003
Having been a taboo subject for many years, dedicated regulatory T cells are now center stage. To the transplantation immunologist, this should not come as a surprise, given that transferable T-cell tolerance has remained a robust phenomenon over the past 2 decades.
Marina I. Garin, Robert I. Lechler
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Having been a taboo subject for many years, dedicated regulatory T cells are now center stage. To the transplantation immunologist, this should not come as a surprise, given that transferable T-cell tolerance has remained a robust phenomenon over the past 2 decades.
Marina I. Garin, Robert I. Lechler
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T regulatory cells and allergy
Microbes and Infection, 2005Anergy, tolerance and active suppression may not be independent events, but rather involve similar mechanisms and cell types in immune regulation. Induction of allergen-specific T(Reg) cells seems essential for maintaining a healthy immune response towards allergens. By utilizing multiple secreted cytokines and surface molecules, antigen-specific T(Reg)
Cezmi A. Akdis +3 more
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Regulatory T cells in Arthritis
2015Rheumatoid arthritis (RA) is one of the most common autoimmune diseases and is characterized by inflammation and subsequent bone destruction in multiple joints. In mice, depletion of regulatory T (Treg) cells results in the onset of a variety of autoimmune diseases including arthritis, while replenishment of Treg cells alleviates arthritic symptoms ...
Noriko Komatsu, Hiroshi Takayanagi
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The life of regulatory T cells
Annals of the New York Academy of Sciences, 2013Foxp3+ regulatory T (Treg) cells are essential for maintaining self‐tolerance and preventing autoimmune reactions. Treg cells arise as a consequence of self‐antigen recognition during the maturation of cells in the thymus, and also following self‐antigen recognition in the periphery.
Iris K. Gratz +2 more
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2018
The tumor microenvironment consists of numerous and diverse immune cells many of which act to suppress the immune system response against cancer cells. Regulatory T cells (Tregs) perform a key role in mediating this immunosuppressive response via a variety of mechanisms.
Breelyn A. Wilky, Vaia Florou
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The tumor microenvironment consists of numerous and diverse immune cells many of which act to suppress the immune system response against cancer cells. Regulatory T cells (Tregs) perform a key role in mediating this immunosuppressive response via a variety of mechanisms.
Breelyn A. Wilky, Vaia Florou
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