mRNA mutations of type I protein kinase A regulatory subunit α in T lymphocytes of a subject with systemic lupus erythematosus [PDF]
, 2000 Dama Laxminarayana, Gary M. Kammer
openalex +1 more source
Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy
Advanced Healthcare Materials, EarlyView.The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq +4 more
wiley +1 more source
BACH2: The Future of Induced T-Regulatory Cell Therapies
CellsBACH2 (BTB Domain and CNC Homolog 2) is a transcription factor that serves as a central regulator of immune cell differentiation and function, particularly in T and B lymphocytes.
Daniel Zwick +4 more
doaj +1 more source
CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway [PDF]
, 2000 Stefania Parlato +8 more
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Imine Crosslinked, Injectable, and Self‐Healing Fucoidan Hydrogel with Immunomodulatory Properties
Advanced Healthcare Materials, EarlyView.This study develops an injectable fucoidan‐based hydrogel with tunable properties for tissue engineering. By oxidizing fucoidan (OFu) to introduce aldehydes, imine crosslinks are formed with amine‐containing polymers, enabling self‐healing, injectability, and long‐term stability (≥28 days). The OFu‐gelatin hydrogel demonstrated biocompatibility, immune‐
Asma Talib Qureshi +3 more
wiley +1 more source
Immunological MedicineOur aim is to determine the number of leukocytes, T lymphocytes and B lymphocytes and the expression of activation markers CD200 and CD23 on B lymphocytes in atopic dermatitis (AD) patients (treated and not treated with dupilumab) during the pollen ...
Jarmila Čelakovská +4 more
doaj +1 more source
Anergic T Lymphocytes Selectively Express an Integrin Regulatory Protein of the Cytohesin Family [PDF]
, 2000 Ulf Korthäuer +8 more
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FlowCyt: A Comparative Study of Deep Learning Approaches for Multi-Class Classification in Flow Cytometry Benchmarking [PDF]
arXivThis paper presents FlowCyt, the first comprehensive benchmark for multi-class single-cell classification in flow cytometry data. The dataset comprises bone marrow samples from 30 patients, with each cell characterized by twelve markers. Ground truth labels identify five hematological cell types: T lymphocytes, B lymphocytes, Monocytes, Mast cells, and
arxiv
Dendrimer Conjugates with PD‐L1‐Binding Peptides Enhance In Vivo Antitumor Immune Response
Advanced Healthcare Materials, EarlyView.In this paper, a novel nanoparticle scaffold composed of dendrimers conjugated with peptide‐based immune checkpoint inhibitors, enhancing drug delivery efficacy is introduced. By conjugating PD‐L1‐binding peptides to dendrimers, multivalent binding effects are harnessed, resulting in enhanced binding affinity, prolonged half‐life, and improved ...
DaWon Kim +11 more
wiley +1 more source
Modular control of Boolean network models [PDF]
arXivThe concept of control is crucial for effectively understanding and applying biological network models. Key structural features relate to control functions through gene regulation, signaling, or metabolic mechanisms, and computational models need to encode these.
arxiv