Regulatory T Cell-Enhancing Therapies to Treat Atherosclerosis
Cells, 2021 Experimental studies have provided strong evidence that chronic inflammation triggered by the sub-endothelial accumulation of cholesterol-rich lipoproteins in arteries is essential in the initiation and progression of atherosclerosis.
Hafid Ait-Oufella +2 more
doaj +1 more source
αEβ7 Integrin Identifies Subsets of Pro-Inflammatory Colonic CD4+ T Lymphocytes in Ulcerative Colitis. [PDF]
, 2017 Background and Aims The αEβ7 integrin is crucial for retention of T lymphocytes at mucosal surfaces through its interaction with E-cadherin. Pathogenic or protective functions of these cells during human intestinal inflammation, such as ulcerative ...
Diehl, Lauri +15 more
core +1 more source
A thermodynamical perspective of immune capabilities [PDF]
Journal of Theoretical Biology 287 (2011) 48-63, 2011 We consider the mutual interactions, via cytokine exchanges, among helper lymphocytes, B lymphocytes and killer lymphocytes, and we model them as a unique system by means of a tripartite network. Each part includes all the different clones of the same lymphatic subpopulation, whose couplings to the others are either excitatory or inhibitory (mirroring ...
arxiv +1 more source
Regulatory T Lymphocytes Distribution And Eosinophilic Gastroenteropathy [PDF]
Journal of Allergy and Clinical Immunology, 2007 Patrick M. Vannelli +3 more
openalex +3 more sources
REGULATORY T-CELLS IN CHRONIC LYMPHOCYTIC LEUKEMIA [PDF]
Mediterranean Journal of Hematology and Infectious Diseases, 2012 Regulatory T-cells (Tregs) constitute a small subset of cells that are actively involved in maintaining self-tolerance, in immune homeostasis and in antitumor immunity. They are thought to play a significant role in the progression of cancer and are generally increased in patient with chronic lymphocytic leukemia (CLL).
Giovanni D’Arena +12 more
openaire +9 more sources
Immune Tolerance to Self-Major Histocompatability Complex Class II Antigens after Bone Marrow Transplantation: Role of Regulatory T Cells [PDF]
, 2006 The immune system undergoes rapid reconstitution after autologous or syngeneic bone marrow transplantation with the re-establishment of tolerance to self-antigens. Administration of drugs such as cyclosporine that inhibit thymic-dependent clonal deletion
Hess, Allan D., Thoburn, Christopher J.
core +1 more source
Deep generative selection models of T and B cell receptor repertoires with soNNia [PDF]
, 2020 Subclasses of lymphocytes carry different functional roles to work together to produce an immune response and lasting immunity. Additionally to these functional roles, T and B-cell lymphocytes rely on the diversity of their receptor chains to recognize different pathogens.
arxiv +1 more source
Pathogens, 2023 CD39 is a marker of immune cells such as lymphocytes and monocytes. The CD39/CD73 pathway hydrolyzes ATP into adenosine, which has a potent immunosuppressive effect.
Alaa Elsaghir +5 more
doaj +1 more source
Targeting of IL-2 to cytotoxic lymphocytes as an improved method of cytokine-driven immunotherapy [PDF]
, 2017 The use of high-dose interleukin-2 (IL-2) has fallen out of favor due to severe life-threatening side effects. We have recently described a unique way of directly targeting IL-2 to cytotoxic lymphocytes using a virally encoded immune evasion protein and ...
Fremont, Daved H +6 more
core +2 more sources
HLA-DR in Cytotoxic T lymphocytes predicts breast cancer patients' response to neoadjuvant chemotherapy [PDF]
, 2018 Prediction of breast cancer response to Neoadjuvant Chemotherapy (NACT) is an urgent need to promptly direct non-responder patients to alternative therapies.
Borralho, Paula +4 more
core +2 more sources