Results 61 to 70 of about 279,628 (297)

The Influence of the Regulatory T Lymphocytes on Atherosclerosis [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2007
Atherosclerosis is complex inflammatory disease of the arterial wall, in which T lymphocytes play a significant role.1 Since the recognition that T lymphocytes are present in human atherosclerotic plaque nearly 2 decades ago,2 research has focused on the functional importance of these cells in the atherosclerotic process.
Israel, Gotsman, Rajat, Gupta, Andrew H, Lichtman   +2 more
openaire   +2 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Loss of chromosome Y in regulatory T cells

BMC Genomics
Background Mosaic loss of chromosome Y (LOY) in leukocytes is the most prevalent somatic aneuploidy in aging humans. Men with LOY have increased risks of all-cause mortality and the major causes of death, including many forms of cancer.
Jonas Mattisson, Jonatan Halvardson, Hanna Davies, Bożena Bruhn-Olszewska, Paweł Olszewski, Marcus Danielsson, Josefin Bjurling, Amanda Lindberg, Ammar Zaghlool, Edyta Rychlicka-Buniowska, Jan P. Dumanski, Lars A. Forsberg   +11 more
doaj   +1 more source

Decrease of Tumor-infiltrating Regulatory T Cells Using Pentoxifylline: An Ex Vivo Analysis in Triple-negative Breast Cancer Mouse Model

Iranian Journal of Allergy, Asthma and Immunology, 2022
Triple-negative breast cancer (TNBC) is the most aggressive type of BC with the highest percentage of tumor-infiltrating lymphocytes (TILs). Hence, TIL therapy is considered a promising approach to target TNBC. Depletion of regulatory T cells (Tregs) in
Mohammad Hossein Kazemi, Mahdieh Shokrollahi Barough, Alireza Ghanavatinejad, Zahra Momeni-Varposhti, Samaneh Khorrami, Behnam Sadeghi, Reza Falak   +6 more
doaj  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

IL-24 producing regulatory T and B lymphocytes in endometriosis

Frontiers in Immunology
ProblemUnbalanced production of pro- and anti-inflammatory cytokines by immune cells is a hallmark of endometriosis. IL-24, a member of the IL-10 family, is a pleiotropic cytokine produced by both non-immune cells like astrocytes, keratinocytes ...
Anna Ewa Kedzierska, Daria Lorek, Anna Slawek, Mikolaj Karmowski, Aleksandra Kalota, Jaroslaw Pajak, Jaroslaw Pajak, Agnieszka Chrobak, Krzysztof Grzymajlo, Anna Chelmonska-Soyta   +9 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The Role of T Regulatory Lymphocytes in Lymphoma

Middle East Journal of Cancer, 2014
T regulatory cells play a crucial role in immunological unresponsiveness to self- antigens and in suppressing excessive immune responses deleterious to the host. T regulatory cells are produced in the thymus as a functionally mature subpopulation of T
Ahmad Nasser, Afra Khosravi, Reza Azizian   +2 more
doaj  

Clinical and prognostic significance of T-regulatory cells and CD28 expression on T-lymphocytes in patients with immune thrombocytopenia

Онкогематология
Background. The leading role in the control of the immune response and peripheral tolerance is played by T-regulatory cells, as well as costimulatory molecules C28 on T-lymphocytes, which are necessary for effective activation.
Yu. Yu. Chuksina, S. G. Zakharov, T. A. Mitina, A. N. Khmelevskaya   +3 more
doaj   +1 more source

RFX transcription factors control a miR-150/PDAP1 axis that restrains the proliferation of human T cells.

PLoS Biology, 2022
Within the immune system, microRNAs (miRNAs) exert key regulatory functions. However, what are the mRNA targets regulated by miRNAs and how miRNAs are transcriptionally regulated themselves remain for the most part unknown. We found that in primary human
Michele Chirichella, Niccolò Bianchi, Emina Džafo, Elena Foli, Francesco Gualdrini, Amy Kenyon, Gioacchino Natoli, Silvia Monticelli   +7 more
doaj   +1 more source