Results 1 to 10 of about 106,778 (281)

Supporting Witnesses and Victims to Invoke Episodic Retrieval Mode: Own-Generated Verbal- and Sketch-Reinstatement-of-Context Retrieval Cues Improves Recall Versus Interviewer-Generated Mental Reinstatement of Context Cues [PDF]

Behavioral Sciences
Background: Criminal justice relies on information from witnesses. Retrieval from episodic memory is cognitively demanding; thus, many interview protocols advocate techniques to support episodic retrieval mode, which is essential for obtaining detailed ...
Coral J. Dando, Rachael V. Dando, Hannah Richardson, Aurora Osorio Rojas, Donna A. Taylor   +4 more
doaj   +2 more sources

DUSP5 Downregulation in Nucleus Accumbens Core Correlates with Cocaine-Induced Maladaptive Synaptic Plasticity [PDF]

Cells
The United States is currently facing a drug overdose epidemic. The nucleus accumbens core (NAcore), a brain region critical for reward and aversion behaviors, undergoes structural and functional synaptic adaptations in response to chronic drug exposure.
Juan Pablo Taborda-Bejarano, Michael Meyerink, Debbie C. Crans, Ramani Ramchandran, Constanza Garcia-Keller   +4 more
doaj   +2 more sources

The effect of intracerebroventricular injection of insulin-like growth factor-1 on morphine-induced conditioned place preference extinction and reinstatement; a behavioral and biochemical experimental study [PDF]

Behavioral and Brain Functions
Background Morphine addiction is a growing problem with severe consequences. Interestingly, Insulin-like Growth Factor-1 (IGF-1), a hormone with the ability to modulate neural pathways and exert neuroprotective and regenerative properties, could emerge ...
Erfan Ghadirzadeh, Mobina Gheibi, Ali Siahposht-Khachaki, Ehsan Vahdati Helan, Mohammad Farvardin, Shiva Shadi, Ali Abdolkarimi   +6 more
doaj   +2 more sources

Misclassification in memory modification in AppNL-G-F knock-in mouse model of Alzheimer’s disease [PDF]

eLife
Alzheimer’s disease (AD), the leading cause of dementia, could potentially be mitigated through early detection and interventions. However, it remains challenging to assess subtle cognitive changes in the early AD continuum.
Mei-Lun Huang, Yusuke Suzuki, Hiroki Sasaguri, Takashi Saito, Takaomi C Saido, Itaru Imayoshi   +5 more
doaj   +2 more sources

Glutamate receptor-interacting protein 1 in D1- and D2-dopamine receptor-expressing medium spiny neurons differentially regulates cocaine acquisition, reinstatement, and associated spine plasticity

Frontiers in Cellular Neuroscience, 2022
BackgroundThe nucleus accumbens (NAc) is involved in the expression of cocaine addictive phenotypes, including acquisition, extinction, and reinstatement.
He Chen, Limei Chen, Zhirong Yuan, Jiajie Yuan, Yitong Li, Yuesi Xu, Jieyi Wu, Lu Zhang, Guohua Wang, Juan Li   +9 more
doaj   +1 more source

Intolerance of uncertainty predicts altered threat expectancy ratings during reinstatement

Journal of Experimental Psychopathology, 2022
Intolerance of uncertainty (IU) is a transdiagnostic risk factor for psychiatric disorders, and plays an important role in fear and threat learning under uncertainty.
Daniel V Zuj, Simon Dymond, Stuart B Murray, Shaima Thomas, Jayne Morriss   +4 more
doaj   +1 more source

Multimodal assessment of long-term memory recall and reinstatement in a combined cue and context fear conditioning and extinction paradigm in humans. [PDF]

PLoS ONE, 2013
Learning to predict danger via associative learning processes is critical for adaptive behaviour. After successful extinction, persisting fear memories often emerge as returning fear. Investigation of return of fear phenomena, e.g.
Jan Haaker, Tina B Lonsdorf, Alexandra Thanellou, Raffael Kalisch   +3 more
doaj   +1 more source

Identification of brain nuclei implicated in cocaine-primed reinstatement of conditioned place preference: a behaviour dissociable from sensitization. [PDF]

PLoS ONE, 2010
Relapse prevention represents the primary therapeutic challenge in the treatment of drug addiction. As with humans, drug-seeking behaviour can be precipitated in laboratory animals by exposure to a small dose of the drug (prime).
Robyn Mary Brown, Jennifer Lynn Short, Andrew John Lawrence   +2 more
doaj   +1 more source

Impact of Perineuronal Net Removal in the Rat Medial Prefrontal Cortex on Parvalbumin Interneurons After Reinstatement of Cocaine Conditioned Place Preference

Frontiers in Cellular Neuroscience, 2022
Parvalbumin (PV)-positive cells are GABAergic fast-spiking interneurons that modulate the activity of pyramidal neurons in the medial prefrontal cortex (mPFC) and their output to brain areas associated with learning and memory.
Angela E. Gonzalez, Angela E. Gonzalez, Emily T. Jorgensen, Jonathan D. Ramos, John H. Harkness, Jake A. Aadland, Travis E. Brown, Barbara A. Sorg, Barbara A. Sorg   +8 more
doaj   +1 more source

Effects of Glucagon-Like Peptide-1 Receptor Agonist Exendin-4 on the Reinstatement of Cocaine-Mediated Conditioned Place Preference in Mice

Frontiers in Behavioral Neuroscience, 2022
A high percentage of relapse to compulsive cocaine-taking and cocaine-seeking behaviors following abstinence constitutes a major obstacle to the clinical treatment of cocaine addiction.
Changliang Zhu, Changliang Zhu, Lei Wang, Jiangwei Ding, Hailiang Li, Hailiang Li, Din Wan, Yangyang Sun, Baorui Guo, Zhenquan He, Xiaofan Ren, Shucai Jiang, Shucai Jiang, Caibing Gao, Caibing Gao, Hua Guo, Tao Sun, Tao Sun, Feng Wang, Feng Wang   +19 more
doaj   +1 more source