Results 21 to 30 of about 107,620 (301)
Brain Sciences, 2012 Reinstatement of conditioned place preferences have been used to investigate physiological mechanisms mediating drug-seeking behavior in adolescent and adult rodents; however, it is still unclear how psychostimulant exposure during adolescence affects ...
Kimberly A. Badanich, Cheryl L. Kirstein
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Glutamate and reinstatement [PDF]
Current Opinion in Pharmacology, 2009 The importance of glutamate in the reinstatement of cocaine-seeking behavior has been established. New molecular and neurochemical adaptations in the glutamatergic system which drive cocaine relapse have been identified, such as the ability of CB1 receptor stimulation to reduce basal glutamate levels and the involvement of the GluR1 receptor subunit in
Lori A, Knackstedt, Peter W, Kalivas
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Augmented Cocaine Seeking in Response to Stress or CRF Delivered into the Ventral Tegmental Area Following Long-Access Self-Administration Is Mediated by CRF Receptor Type 1 But Not CRF Receptor Type 2 [PDF]
, 2011 Stressful events are determinants of relapse in recovering cocaine addicts. Excessive cocaine use may increase susceptibility to stressor-induced relapse through alterations in brain corticotropin-releasing factor (CRF) regulation of neurocircuitry ...
Baker, David A. +6 more
core +2 more sources
Prefrontal dopamine regulates fear reinstatement through the downregulation of extinction circuits
eLife, 2015 Prevention of relapses is a major challenge in treating anxiety disorders. Fear reinstatement can cause relapse in spite of successful fear reduction through extinction-based exposure therapy.
Natsuko Hitora-Imamura +5 more
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Self-Administration of Toluene Vapor in Rats
Frontiers in Neuroscience, 2020 Inhalants, including volatile organic solvents such as toluene, continue to be one of the most prevalent, and often first substances abused by adolescents.
Kevin M. Braunscheidel +3 more
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Gradual extinction reduces reinstatement [PDF]
Frontiers in Behavioral Neuroscience, 2015 The current study investigated whether gradually reducing the frequency of aversive stimuli during extinction can prevent the return of fear. Thirty-one participants of a three-stage procedure (acquisition, extinction and a reinstatement test on day 2) were randomly assigned to a standard extinction (SE) and gradual extinction (GE) procedure.
Shiban, Youssef +3 more
openaire +4 more sources
Stress-Induced Cocaine Seeking Requires a Beta-2 Adrenergic Receptor-Regulated Pathway from the Ventral Bed Nucleus of the Stria Terminalis That Regulates CRF Actions in the Ventral Tegmental Area [PDF]
, 2014 The ventral bed nucleus of the stria terminalis (vBNST) has been implicated in stress-induced cocaine use. Here we demonstrate that, in the vBNST, corticotropin releasing factor (CRF) is expressed in neurons that innervate the ventral tegmental area (VTA)
Baker, David A. +4 more
core +2 more sources
Reinstatement of extinguished fear by an unextinguished conditional stimulus
Frontiers in Behavioral Neuroscience, 2012 Anxiety disorders are often treated using extinction-based exposure therapy, but relapse is common and can occur as a result of reinstatement, whereby an aversive trigger can reinstate extinguished fear. Animal models of reinstatement commonly utilize a
Lindsay R Halladay +4 more
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Stronger memory representation after memory reinstatement during retrieval in the human hippocampus
NeuroImage, 2022 Memory retrieval allows us to reinstate previously encoded information but is also considered to contribute to memory enhancement. Retrieval-induced enhancement may involve processing to strengthen memory traces, but neural processing beyond ...
Joonyoung Kang +2 more
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Frontiers in Behavioral Neuroscience, 2022 IntroductionRates of relapse to drug use during abstinence are among the highest for opioid use disorder (OUD). In preclinical studies, reinstatement to drug-seeking has been extensively studied as a model of relapse–but the work has been primarily in ...
Suman K. Guha +8 more
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