Results 11 to 20 of about 17,592 (257)

Effects of Glucagon-Like Peptide-1 Receptor Agonist Exendin-4 on the Reinstatement of Cocaine-Mediated Conditioned Place Preference in Mice

Frontiers in Behavioral Neuroscience, 2022
A high percentage of relapse to compulsive cocaine-taking and cocaine-seeking behaviors following abstinence constitutes a major obstacle to the clinical treatment of cocaine addiction.
Changliang Zhu, Changliang Zhu, Lei Wang, Jiangwei Ding, Hailiang Li, Hailiang Li, Din Wan, Yangyang Sun, Baorui Guo, Zhenquan He, Xiaofan Ren, Shucai Jiang, Shucai Jiang, Caibing Gao, Caibing Gao, Hua Guo, Tao Sun, Tao Sun, Feng Wang, Feng Wang   +19 more
doaj   +1 more source

Voluntary alcohol intake alters the motivation to seek intravenous oxycodone and neuronal activation during the reinstatement of oxycodone and sucrose seeking

Scientific Reports, 2023
Opioid-alcohol polysubstance use is prevalent and worsens treatment outcomes. Here we assessed whether co-consumption of oxycodone and alcohol influence the intake of one another, demand for oxycodone, and the neurocircuitry underlying cue-primed ...
Courtney S. Wilkinson, Harrison L. Blount, Shane Davis, Giselle Rojas, Lizhen Wu, Niall P. Murphy, Marek Schwendt, Lori A. Knackstedt   +7 more
doaj   +1 more source

Stronger memory representation after memory reinstatement during retrieval in the human hippocampus

NeuroImage, 2022
Memory retrieval allows us to reinstate previously encoded information but is also considered to contribute to memory enhancement. Retrieval-induced enhancement may involve processing to strengthen memory traces, but neural processing beyond ...
Joonyoung Kang, Wonjun Kang, Sue-Hyun Lee   +2 more
doaj   +1 more source

Inactivation of the nucleus accumbens core or medial shell attenuates reinstatement of sugar-seeking behavior following sugar priming or exposure to food-associated cues. [PDF]

PLoS ONE, 2014
Re-exposure to either palatable food or to conditioned stimuli associated with food is known to reinstate food-seeking after periods of abstinence.
Peagan Lin, Wayne E Pratt
doaj   +1 more source

Impact of tobacco smoke constituents on nicotine-seeking behavior in adolescent and adult male rats

Frontiers in Psychiatry, 2023
IntroductionGiven the rapid increase in teen vaping over recent years it is critical to understand mechanisms underlying addiction and relapse to tobacco use at this age.
Candice A. Gellner, Diana Carreño, James D. Belluzzi, Frances M. Leslie   +3 more
doaj   +1 more source

The Role of Beta-Endorphin in Cocaine-Induced Conditioned Place Preference, Its Extinction, and Reinstatement in Male and Female Mice

Frontiers in Behavioral Neuroscience, 2021
Endogenous opioids have been implicated in cocaine reward. However, the role of each opioid peptide in this regard is unknown. Notably, the role of each peptide in extinction and reinstatement is not fully characterized. Thus, we assessed whether cocaine-
Prableen K. Singh, Kabirullah Lutfy
doaj   +1 more source

Suppression weakens unwanted memories via a sustained reduction of neural reactivation

eLife, 2022
Aversive events sometimes turn into intrusive memories. However, prior evidence indicates that such memories can be controlled via a mechanism of retrieval suppression.
Ann-Kristin Meyer, Roland G Benoit
doaj   +1 more source

Prefrontal dopamine regulates fear reinstatement through the downregulation of extinction circuits

eLife, 2015
Prevention of relapses is a major challenge in treating anxiety disorders. Fear reinstatement can cause relapse in spite of successful fear reduction through extinction-based exposure therapy.
Natsuko Hitora-Imamura, Yuki Miura, Chie Teshirogi, Yuji Ikegaya, Norio Matsuki, Hiroshi Nomura   +5 more
doaj   +1 more source

Ibogaine Blocks Cue- and Drug-Induced Reinstatement of Conditioned Place Preference to Ethanol in Male Mice

Frontiers in Pharmacology, 2021
Ibogaine is a psychedelic extracted from the plant Tabernanthe iboga Baill. (Apocynaceae), natural from Africa, and has been proposed as a potential treatment for substance use disorders.
Gabrielle M. Henriques, Alexia Anjos-Santos, Alexia Anjos-Santos, Isa R. S. Rodrigues, Victor Nascimento-Rocha, Henrique S. Reis, Matheus Libarino-Santos, Thaísa Barros-Santos, Thais S. Yokoyama, Natalia B. Bertagna, Cristiane A. Favoretto, Célia R. G. Moraes, Fábio C. Cruz, Paulo C. R. Barbosa, Eduardo A. V. Marinho, Alexandre J. Oliveira-Lima, Laís F. Berro, Laís F. Berro   +17 more
doaj   +1 more source

Cocaine-Induced Reinstatement of a Conditioned Place Preference in Developing Rats: Involvement of the D2 Receptor

Brain Sciences, 2012
Reinstatement of conditioned place preferences have been used to investigate physiological mechanisms mediating drug-seeking behavior in adolescent and adult rodents; however, it is still unclear how psychostimulant exposure during adolescence affects ...
Kimberly A. Badanich, Cheryl L. Kirstein
doaj   +1 more source