Results 41 to 50 of about 3,050 (213)

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

open access: yesFEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park   +8 more
wiley   +1 more source

Psychological, cultural and communicative conditioning for sexual education of bilingual deaf pupils

open access: yesTransformación, 2010
The psychological, cultural and communicative conditions are prerequisite for organizing the educative process of sexuality of deaf pupils with a bilingual approach.
García, Mirna Maura
doaj  

Crafting sustainability? An explorative study of craft in three countercultures as a learning path for the future

open access: yesNordic Journal of Science and Technology Studies, 2017
This article explores and seeks to identify what ‘crafting sustainability’ could mean in relation to education for sustainable development (ESD). Certain ESD craft pedagogies are explored in three countercultures (from 1900, 1968 and 2017). The empirical
Hanna Hofverberg   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Educative intervention on oral/dental health in diabetic patients May-October 2008

open access: yesActa Médica del Centro, 2009
A quasi-experimental educative intervention study, without control group, and with a before-after design was carried out with 30 diabetic patients from the Chiqui Gómez Polyclinic who were treated at the Center for Education and Care of diabetic patients
Abdel Antonio Moré Duarte   +3 more
doaj  

Les rituels en question dans la relation éducative : rupture des liens, maintien du lien, instauration de nouveaux liens

open access: yesRecherches en Éducation, 2015
The contemporary deritualization, correlative to a progressively more individualized social act, highlights the embrittlement of the social link within educational institutions.
Christiane Montandon
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

The Construction of Indicators and Quality Assessment in Education Centers. Six Experiences in México

open access: yesRevista Iberoamericana sobre Calidad, Eficacia y Cambio en Educación, 2016
The educational system in Mexico has made great efforts to improve its quality over the past decades. Two main lines of work have been defined. The first step has been to ensure that the term “education of quality” to work as the axis of the educative ...
José Francisco Martínez Preciado
doaj  

Le plurilinguisme à l’école marocaine : gestion et représentations [PDF]

open access: yesAkofena
Résumé: Les différentes langues utilisées dans le milieu scolaire ont des statuts et des usages variés qui sont choisis, précisés, et même imposés par la politique éducative cherchant essentiellement à gérer le plurilinguisme à l’école en prenant en ...
Faiza AIT AISSA & Kheira KEMBOUCHE
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

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