Results 31 to 40 of about 3,050 (213)
O discurso de parto de mulheres vivenciando a experiência da primeira gestação
Saúde e Sociedade, 1996 Este trabalho é parte integrante de um estudo realizado junto a um grupo de mulheres, clientes de um centro de saúde escola, que vivenciavam a experiência da primeira gravidez, com o objetivo de desenvolver e avaliar uma ação educativa participante.
Marcia R. Nozawa, Néia Schor
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
La formación competente del profesional de la bibliotecología y las ciencias de la información [PDF]
Transformación, 2018 This paper approaches competent professional training as an alternative university competency-based education. The objective of the article is to analyze the competent formation of librarians and information sciences professionals from three different ...
Martha Cecilia Escobar García +1 more
doaj
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Que savent les élèves en Finlande ?
Revue Internationale d’Éducation de Sèvres, 2006 The Finnish school system is characterized by a transparent and flexible interaction between the national level and the steps taken by towns and schools. The national objectives build a precise and well-structured framework; the contents are defined on a
Irmeli Halinen +2 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Didasc@lia: didáctica y educación, 2010 The science-technology and society approach (STS) underlines a consideration about science and technology as social phenomena. Its educative dimension can be manifested through the incorporation of the conceptual content, the means and didactic ...
Alberto Bujardón Mendoza +1 more
doaj