Results 51 to 60 of about 3,050 (213)
Simone Weil, philosophe et éducatrice
Cahiers de NarratologieCette contribution analyse la place que l’éducation a occupé dans la vie et l’œuvre de la philosophe française Simone Weil. Elle se fonde d’une part sur son expérience personnelle de l’enseignement formel en lycée et informel auprès de travailleurs ...
Daniela De Leo
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Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
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Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
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Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
Revista Iberoamericana sobre Calidad, Eficacia y Cambio en Educación, 2016 The present work shows the process carried out in two years (2007-2009), within the framework of a project of collaboration between an educative center of Infantile and Primary Education and the Department of Didactics of the University of Alcala, with ...
Mario Martín Bris +1 more
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Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
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Re-writing knowledge, re-design textbooks: auto-production of contents in the classroom [PDF]
Educar em RevistaThis contribution is a report of a qualitative research carried out within the Avanguardie Educative project aimed at describing and analyzing the experience of a group of Italian teachers in relation to the practice of textbook and digital resources ...
Alessandra Anichini, Laura Parigi
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Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
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Pedagogical professional training in Cuban educative context
Transformación, 2015 The conception of the pedagogical professional training has evolved alongside with the educative changes that have taken place in the history of Cuban education.
Mayre Acosta Calderón +1 more
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Mesure et Évaluation en Éducation, 2000 L’objet de notre recherche est d’évaluer les effets des actions de formation continue sur les pratiques professionnelles du pharmacien d’officine diplômé.
Nathalie Calop
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