Results 91 to 100 of about 24,582,015 (196)

Relaxin family peptides: structure-activity relationship studies [PDF]

, 2017
The human relaxin peptide family consists of seven cystine-rich peptides, four of which are known to signal through relaxin family peptide receptors, RXFP1-4.
John D Wade, K Johan Rosengren, Mohammed Akhter Hossain, Separovic, Frances, Frances Separovic, Separovic, F, Rosengren, KJ, Wade, John D., Wade, JD, Bathgate, RAD, Rosengren, K. Johan, Hossain, Mohammed Akhter, Patil, NA, Patil, Nitin A., Hossain, MA, Bathgate, Ross A. D., Nitin A Patil, Ross A D Bathgate   +17 more
core   +1 more source

Relaxin-3 receptor (Rxfp3) gene knockout mice display reduced running wheel activity: implications for role of relaxin-3/RXFP3 signalling in sustained arousal

, 2015
Anatomical and pharmacological evidence suggests the neuropeptide, relaxin-3, is the preferred endogenous ligand for the relaxin family peptide-3 receptor (RXFP3) and suggests a number of putative stress- and arousal-related roles for RXFP3 signalling ...
SW Sutton (14876671), AL Gundlach (14448708), Craig Smith (13065255), IT Hosken (14876668)   +3 more
core  

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1

Scientific Reports, 2017
Activation of the relaxin receptor RXFP1 has been associated with improved survival in acute heart failure. ML290 is a small molecule RXFP1 agonist with simple structure, long half-life and high stability.
Martina Kocan, Mohsin Sarwar, Sheng Y. Ang, Jingbo Xiao, Juan J. Marugan, Mohammed A. Hossain, Chao Wang, Dana S. Hutchinson, Chrishan S. Samuel, Alexander I. Agoulnik, Ross A. D. Bathgate, Roger J. Summers   +11 more
doaj   +1 more source

Increased plasma levels of relaxin-2 in liver cirrhotic patients [PDF]

, 2019
Abstract Background: Relaxin-2 has been found to alleviate fibrosis in liver cirrhosis, and our previous study showed that relaxin-3 inhibits ROS-induced hepatic cell apoptosis. In this study, we investigated the levels of plasma relaxin-2 or relaxin-3 in patients with liver cirrhosis and their relationship to component traits in patients with ...
Xiao Ma, Yu Pan, Ruiling Xu, Mingna Liu, Xiaohui Zhang   +4 more
openaire   +1 more source

RELAXIN-3/RXFP3 signalling promotes motivational drive and stress resilience in mice

, 2015
RELAXIN-3/RXFP3 signalling promotes motivational drive and stress resilience in ...
E Timofeeva (13357596), D Denton (13594021), A Gundlach (13646296), A Walker (9855653), I Hosken (13748437), M McKinley (13594015), Craig Smith (13065255), B Chua (13748431), C Zhang (2567170), A Lawrence (9877598)   +9 more
core  

Translational pharmacokinetic/pharmacodynamic model for mRNA‐0184, an investigational therapeutic for the treatment of heart failure

Clinical and Translational Science
Heart failure (HF) is a complex, progressive disorder that is associated with substantial morbidity and mortality on a global scale. Relaxin‐2 is a naturally occurring hormone that may have potential therapeutic benefit for patients with HF.
Neeraj Kaushal, Husain Attarwala, Mir Javid Iqbal, Rajnish Saini, Linh Van, Min Liang   +5 more
doaj   +1 more source

Relaxin gene family in teleosts: phylogeny, syntenic mapping, selective constraint, andexpression analysis

BMC Evolutionary Biology, 2009
Background In recent years, the relaxin family of signaling molecules has been shown to play diverse roles in mammalian physiology, but little is known about its diversity or physiology in teleosts, an infraclass of the bony fishes comprising ~ 50% of ...
Glen Peter, Bogerd Jan, Harron Scott, Yegorov Sergey, Good-Avila Sara V, Ozon James, Wilson Brian C   +6 more
doaj   +1 more source

Relaxin-3/RXFP3 signalling in mouse hypothalamus: no effect of RXFP3 activation on corticosterone, despite reduced presynaptic excitatory input onto paraventricular CRH neurons in vitro

, 2017
Relaxin-3/RXFP3 signalling is proposed to be involved in the neuromodulatory control of arousal- and stress-related neural circuits. Furthermore, previous studies in rats have led to the proposal that relaxin-3/RXFP3 signalling is associated with ...
JS Bains (14876695), DV Baimoukhametova (14876692), AL Gundlach (14448708), Craig Smith (13065255), C Zhang (2567170)   +4 more
core  

Biology of primate relaxin: A paracrine signal in early pregnancy?

, 2004
Relaxin is a peptide hormone that exerts numerous effects in a variety of tissues across a broad range of species. Although first identified more than 75 years ago interest in relaxin biology has waxed and waned over the years consistent with peaks and ...
Eric S Hayes, Hayes Eric S
core   +1 more source

Periodic injections of Relaxin 2, its pharmacokinetics and remodeling of rat hearts

Biochemical Pharmacology
Relaxin-2 (RLX), a critical hormone in pregnancy, has been investigated as a therapy for heart failure. In most studies, the peptide was delivered continuously, subcutaneously for 2 weeks in animals or intravenously for 2-days in human subjects, for stable circulating [RLX].
Beth Gabris-Weber, Rameen Forghani, Thomas Bernd Dschietzig, Guillermo Romero, Guy Salama   +4 more
openaire   +2 more sources