Results 81 to 90 of about 24,582,015 (196)

Relaxin 2 Is Functional at the Ocular Surface and Promotes Corneal Wound Healing

Investigative Opthalmology & Visual Science, 2012
We aimed to determine if the insulin-like peptide hormone relaxin 2 (RLN2) is expressed at the ocular surface and in tears and if RLN2 influences wound healing at the ocular surface, which is associated with extracellular matrix (ECM) remodeling.We analyzed transcript levels of human RLN2 and its cognate relaxin-like receptors RXFP1 and RXFP2 in ...
Ulrike, Hampel, Thomas, Klonisch, Eugenia, Makrantonaki, Saadettin, Sel, Ute, Schulze, Fabian, Garreis, Holger, Seltmann, Christos C, Zouboulis, Friedrich P, Paulsen   +8 more
openaire   +2 more sources

Bushen Huatan Formula Ameliorates Early Chronic Low‐Grade Inflammation in Obese PCOS Via the TLR4/NF‐κB Signaling Pathway: An Integrated Network Pharmacology and Experimental Study

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Objective This study used an integrated network pharmacology and experimental strategy to investigate how Bushen Huatan Formula (BHF) mitigates early‐stage chronic low‐grade inflammation in obese polycystic ovary syndrome (PCOS). Methods Candidate components and targets of BHF were retrieved from the TCMSP database, and protein–protein ...
Jianing Zhang, Fangyun Gu, Yunyun Li, Xiaoling Feng, Hongying Kuang, Fang Xu, Miao Sun   +6 more
wiley   +1 more source

Non‐Pharmacological Interventions for the Treatment of Lumbopelvic Pain in Pregnant Women: A Systematic Review Protocol Using the TIDieR Checklist

Musculoskeletal Care, Volume 24, Issue 3, September 2026.
ABSTRACT Background Lumbopelvic pain (LPP) is one of the most common complaints during pregnancy, with a reported prevalence of 63%. During pregnancy, treatment should preferably be non‐invasive. However, scientific evidence on non‐pharmacological interventions for pregnant women with LPP is still limited. Objective To synthesise the available evidence
Marília Caroline Ventura Macedo Leite, Mateus Dantas Azevedo de Lima, Rafaela Jéssica Silveira de Souza, Vanessa Patrícia Soares de Souza, Elizabel de Souza Ramalho Viana   +4 more
wiley   +1 more source

Relaxin-3 inputs target hippocampal interneurons and deletion of hilar relaxin-3 receptors in “floxed-RXFP3” mice impairs spatial memory

, 2017
Relaxin-3 inputs target hippocampal interneurons and deletion of hilar relaxin-3 receptors in “floxed-RXFP3” mice impairs spatial ...
RAD Bathgate (14876653), E Timofeeva (13357596), G Guèvremont (13357590), M Haidar (13357587), AL Gundlach (14448708), Craig Smith (13065255), C Zhang (2567170)   +6 more
core  

Characterization of Lipizzan Horse Population From Lipica Stud Using Molecular and Pedigree Data

Animal Genetics, Volume 57, Issue 4, August 2026.
ABSTRACT In this study, we analysed genetic diversity, population structure and inbreeding in the Lipica Stud Farm population by integrating pedigree records, microsatellite (STR) and genome‐wide SNP data generated using the GGP Equine 70K BeadChip. The dataset comprised 233 horses from the Lipica Stud Farm, which served as the reference population for
Tamara Ferme, Minja Zorc, Marko Cotman, Matjaž Mesarič, Peter Dovč   +4 more
wiley   +1 more source

Relaxin-3 null mutation mice display a circadian hypoactivity phenotype

, 2012
Characterizing the neurocircuits and neurotransmitters that underlie arousal and circadian sleep/wake patterns is an important goal of neuroscience research, with potential implications for understanding human mental illnesses, such as major depression ...
SW Sutton (14876671), AL Gundlach (14448708), Craig Smith (13065255), IT Hosken (14876668), AJ Lawrence (5578280)   +4 more
core  

Regional Functional Molecular Profiles Within the Mammalian Cortex: A Commentary on Limbic Mesocortex

Journal of Comparative Neurology, Volume 534, Issue 8, August 2026.
Two lateral mouse brain sagittal sections labeled, respectively, for Lypd1 (A) and Kcnab3 (B). (A) Lypd1 labels positively cortical Layers 2 and 5 (less heavily), but only at limbic mesocortical sites, forming the limbic ring that separates the unlabeled isocortex (IsoCx) from the unlabeled hippocampal and olfactory allocortex (Hi, Sub, ERh; OlfCx ...
Luis Puelles, Elena Garcia‐Calero
wiley   +1 more source

Septal GABA and Glutamate Neurons Express RXFP3 mRNA and Depletion of Septal RXFP3 Impaired Spatial Search Strategy and Long-Term Reference Memory in Adult Mice

Frontiers in Neuroanatomy, 2019
Relaxin-3 is a highly conserved neuropeptide abundantly expressed in neurons of the nucleus incertus (NI), which project to nodes of the septohippocampal system (SHS) including the medial septum/diagonal band of Broca (MS/DB) and dorsal hippocampus, as ...
Mouna Haidar, Mouna Haidar, Kimberly Tin, Kimberly Tin, Cary Zhang, Mohsen Nategh, João Covita, João Covita, Alexander D. Wykes, Alexander D. Wykes, Jake Rogers, Jake Rogers, Andrew L. Gundlach, Andrew L. Gundlach, Andrew L. Gundlach   +14 more
doaj   +1 more source

Integrated Network Analysis Suggests an miR‐21/MMP/VEGF‐Associated Regulatory Axis in Gastric Cancer

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background, Aims Gastric cancer (GC) pathogenesis involves complex molecular interactions that remain incompletely understood at a biological systems level. While microRNA‐21 (miR‐21), matrix metalloproteinases (MMPs), and vascular endothelial growth factor (VEGF) have been individually implicated in GC, their integrated role as a coordinated ...
Fatemeh Babajani, Hadi Mozafari
wiley   +1 more source

EVALUATION OF SERUM RELAXIN CONCENTRATIONS AND KNEE VALGUS AFTER ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION

Orthopaedic Journal of Sports Medicine, 2020
Background: Athletes who sustain an anterior cruciate ligament (ACL) injury are more likely to develop adverse health outcomes, such as knee osteoarthritis, knee pain, and obesity.
Gabrielle G. Gilmer BCh, Michael D. Roberts PhD, Gretchen Oliver PhD   +2 more
doaj   +1 more source