Results 71 to 80 of about 24,582,015 (196)

Effects of Selenocysteine Substitution on the Cyclotide Kalata B2

ChemBioChem, Volume 27, Issue 18, 28 September 2026.
Selenocysteine (Sec) substitution of any of the native complementary cysteine (Cys) residues of the cyclotide kalata B2 preserves the structure, cytotoxicity, and membrane‐binding activity while enhancing its folding efficiency. The study shows the conservative nature and folding benefit of selenocysteine replacement in kalata B2.
Ramoncito Luis B. de Boda, Sónia Troeira Henriques, Yen‐Hua Huang, Christine C. Hernandez, Portia Mahal G. Sabido, David J. Craik   +5 more
wiley   +1 more source

Targeting the Relaxin Pathway for Liver Disease Treatment [PDF]

, 2018
Hepatic fibrosis is a progressive disease with few treatment options outside of transplantation. Relaxin is a member of the insulin/relaxin superfamily of peptide hormones. Originally known for its roles in pregnancy, relaxin promotes reproductive tissue
Robert G. Bennett
core  

Gefäßprotektive Effekte von humanem rekombinantem Relaxin-2 im Atherosklerose-Mausmodell [PDF]

, 2018
Einleitung: Relaxin-2 wurde zunächst als Schwangerschaftshormon bekannt und bewirkt systemische hämodynamische und renale Anpassungsvorgänge während der Schwangerschaft.
Schatten, Hannah
core   +1 more source

Relaxin Enhances Bone Regeneration with BMP-2-Loaded Hydroxyapatite Microspheres

, 2020
Our aims were to 1) evaluate the capacity of hollow hydroxyapatite (HA) microspheres (212–250 μm) to serve as a delivery system for controlled release of BMP-2 in vitro and 2) examine relaxin as an enhancer of BMP-2 for bone regeneration.
Sahitya Injamuri, Huang, Yue-Wern, Youqu Shen, Shen, Youqu, Mohamed N. Rahaman, Yue‐Wern Huang, Rahaman, Mohamed N., Rahaman, M. N., Injamuri, Sahitya   +8 more
core   +1 more source

B7‐33, a Functionally Selective Relaxin Receptor 1 Agonist, Attenuates Myocardial Infarction–Related Adverse Cardiac Remodeling in Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Human relaxin‐2 is a peptide hormone capable of pleiotropic effects in several organ systems. Its recombinant formulation (serelaxin) has been demonstrated to reduce infarct size and prevent excessive scar formation in animal models of cardiac
Teja Devarakonda, Adolfo G. Mauro, Geronimo Guzman, Sahak Hovsepian, Chad Cain, Anindita Das, Praveen Praveen, Mohammed Akhter Hossain, Fadi N. Salloum   +8 more
doaj   +1 more source

Systemic Hormonal Contraceptive Use Is Associated With Greater Odds of Rotator Cuff Tears, Shoulder Instability, Dislocation, and Other Shoulder Pathologies: A Propensity Matched Epidemiological Study

Arthroscopy, Volume 42, Issue 9, Page 1529-1537, September 2026.
Purpose To evaluate whether systemic estrogen‐only, progestin‐only, or combined hormonal contraceptives (HCs) are associated with increased risk of shoulder pathologies in reproductive‐age females. Methods A retrospective cohort study of female patients presenting to clinic from 2013 to 2020 and aged 13‐50 with 5 years of follow‐up was conducted using ...
Argen Omurzakov, Arsen M. Omurzakov, Robert J. Burkhart, Aakash K. Shah, Rayyan Abid, James E. Voos, Jacob G. Calcei, John M. Apostolakos   +7 more
wiley   +1 more source

Relaxin 2 – a pregnancy hormone involved in the process of carcinogenesis

Polish Gynaecology, 2013
Relaxin 2 is a polypeptide hormone structurally related to insulin and insulin-like growth factors (IGFs). However it does not interact with insulin receptors and has a decidedly different biological properties. Relaxin 2 activates LGR 7 and LGR 8 relaxin receptors, that belong to the leucine-rich repeat-containing (LRR), G protein-coupled receptors ...
openaire   +2 more sources

Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2

Communications Biology, 2022
Specific small molecule RXFP2 agonists with favorable pharmacokinetic properties induce gubernacular invagination in mouse embryos, increase mineralization activity in human osteoblasts in vitro, and improve bone trabecular parameters in adult mice.
Maria Esteban-Lopez, Kenneth J. Wilson, Courtney Myhr, Elena M. Kaftanovskaya, Mark J. Henderson, Noel T. Southall, Xin Xu, Amy Wang, Xin Hu, Elena Barnaeva, Wenjuan Ye, Emmett R. George, John T. Sherrill, Marc Ferrer, Roy Morello, Irina U. Agoulnik, Juan J. Marugan, Alexander I. Agoulnik   +17 more
doaj   +1 more source

Virtual single‐cell perturbation and genetic causal inference reveal CSF1R‐dependent immunometabolic communication in iron metabolism‐associated osteoarthritis

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Integrative genetic, single‐cell, and perturbation analyses identify CSF1R as a macrophage‐centered immunometabolic signaling hub linking iron dysregulation to osteoarthritis. CSF1R‐driven monocyte–macrophage remodeling may coordinate immune activation, extracellular matrix remodeling, and cartilage degeneration, providing a potential therapeutic ...
Yue Zhou, Guohang Shen, Lijing Si, Kaiyong Wang, Yang Chen, Ruoyan Wang, Yupei Dai   +6 more
wiley   +1 more source

Age‐Associated Four‐Gene Prognostic Signature in Breast Cancer

Cancer Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background Young‐onset breast cancer is associated with inferior disease‐free survival (DFS), but the contribution of additional molecular heterogeneity remains unclear. Aims To identify an exploratory age‐associated gene expression signature linked to recurrence‐related outcomes and evaluate its prognostic association.
Shiro Uchida
wiley   +1 more source