Results 61 to 70 of about 7,173 (124)

Relaxin gene family in teleosts: phylogeny, syntenic mapping, selective constraint, andexpression analysis

BMC Evolutionary Biology, 2009
Background In recent years, the relaxin family of signaling molecules has been shown to play diverse roles in mammalian physiology, but little is known about its diversity or physiology in teleosts, an infraclass of the bony fishes comprising ~ 50% of ...
Glen Peter, Bogerd Jan, Harron Scott, Yegorov Sergey, Good-Avila Sara V, Ozon James, Wilson Brian C   +6 more
doaj   +1 more source

Relaxin-2 for heart failure with preserved ejection fraction: a comment on the termination of a phase-II trial investigating the relaxin-2 analogue, LY3540378

Global Cardiology
On November 25, 2024, Eli Lilly and Company informed the public about the decision to terminate their phase-2 study, J3E-MC-EZDB with the relaxin-2 analogue, LY3540378, after data analysis of 40% of participants had indicated futility without immediate ...
Thomas Bernd Dschietzig, Guy Salama
doaj   +1 more source

Retracted: Relaxin-3 Ameliorates Diabetic Cardiomyopathy by Inhibiting Endoplasmic Reticulum Stress. [PDF]

Comput Math Methods Med, 2023
Methods In Medicine CAM.
europepmc   +1 more source

Serum relaxin-3 and galanin levels in individuals with erectile dysfunction with and without type 2 diabetes mellitus

Medicine Science
This study was designed to determine the serum relaxin-3 and galanin levels in individuals with erectile dysfunction with and without type 2 diabetes mellitus (T2DM).
Umit Yilmaz, Salih Burlukkara, Demirhan Orsan Demir   +2 more
doaj   +1 more source

Development of a selective agonist for relaxin family peptide receptor 3

Scientific Reports, 2017
Relaxin family peptides perform a variety of biological functions by activating four G protein-coupled receptors, namely RXFP1–4. Among these receptors, RXFP3 lacks a specific natural or synthetic agonist at present.
Dian Wei, Meng-Jun Hu, Xiao-Xia Shao, Jia-Hui Wang, Wei-Han Nie, Ya-Li Liu, Zeng-Guang Xu, Zhan-Yun Guo   +7 more
doaj   +1 more source

tHE ROLE OF corticotropin-RELEASING HORMONE IN INITIATION OF LABOR

Медицинский вестник Юга России, 2013
Purpose: To determine the content of corticotropin-releasing hormone, substance P, prostaglandin F2a, neurokinins A and B, interleukins 6 and 8, relaxin and cortisol in the blood serum and amniotic fluid and to evaluate the influence of these markers on ...
T. G. Arutyunyan, V. A. Linde, Zh. A. Elzhorukaeva   +2 more
doaj   +1 more source

The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease. [PDF]

Int J Mol Sci, 2022
Leysen H, Walter D, Clauwaert L, Hellemans L, van Gastel J, Vasudevan L, Martin B, Maudsley S.   +7 more
europepmc   +1 more source

Discovery and Characterization of the First Nonpeptide Antagonists for the Relaxin-3/RXFP3 System. [PDF]

J Med Chem, 2022
Gay EA, Guan D, Van Voorhies K, Vasukuttan V, Mathews KM, Besheer J, Jin C.   +6 more
europepmc   +1 more source

Investigation of Relaxin-3 Serum Levels in terms of Social Interaction, Communication, and Appetite as a Biomarker in Children with Autism. [PDF]

Clin Psychopharmacol Neurosci, 2022
Erden S, Nalbant K, Kılınç İ.
europepmc   +1 more source

Genetically defined nucleus incertus neurons differ in connectivity and function

eLife
The nucleus incertus (NI), a conserved hindbrain structure implicated in the stress response, arousal, and memory, is a major site for production of the neuropeptide relaxin-3.
Emma D Spikol, Ji Cheng, Michelle Macurak, Abhignya Subedi, Marnie E Halpern   +4 more
doaj   +1 more source