Results 1 to 10 of about 534 (107)

Investigating the role of the relaxin-3/RXFP3 system in neuropsychiatric disorders and metabolic phenotypes: A candidate gene approach. [PDF]

PLoS ONE, 2023
The relaxin-3/RXFP3 system has been implicated in the modulation of depressive- and anxiety-like behaviour in the animal literature; however, there is a lack of human studies investigating this signalling system.
Win Lee Edwin Wong, Ryan Arathimos, Cathryn M Lewis, Allan H Young, Gavin S Dawe   +4 more
doaj   +4 more sources

High-Throughput Screening Campaign Identified a Potential Small Molecule RXFP3/4 Agonist

Molecules, 2021
Relaxin/insulin-like family peptide receptor 3 (RXFP3) belongs to class A G protein-coupled receptor family. RXFP3 and its endogenous ligand relaxin-3 are mainly expressed in the brain with important roles in the regulation of appetite, energy metabolism,
Ross Bathgate, Qingtong Zhou, Qing Liu
exaly   +3 more sources

Application of a modified MSRE-qPCR method for detecting circulating cell-free DNA methylation in cervical cancer [PDF]

Frontiers in Oncology
BackgroundThe methylation status of cell-free DNA (cfDNA) shows promise for the clinical detection of cervical cancer and its precursors; however, its measurement in liquid biopsies is hindered by low cfDNA yields and technically demanding protocols ...
Yaru Liu, Yaru Liu, Yaru Liu, Tuping He, Shang Chen, Shenglong Wang, Zhihao Luo, Haixi Liu, Haixi Liu, Quan Liu, Quan Liu, Dixian Luo, Dixian Luo, Dixian Luo   +13 more
doaj   +2 more sources

Sex hormones in the nucleus incertus: a novel perspective on sex/gender differences in memory and mood dysfunction in Alzheimer’s disease [PDF]

Frontiers in Aging Neuroscience
About 60% of the individuals living with Alzheimer’s disease (AD) in the United States are women. Increasing evidence points to a role for sex hormones, especially estrogen, in making women more vulnerable to AD than men.
Camila de Ávila, Ayanabha Chakraborti, Andrew L. Gundlach, Andrew L. Gundlach, Andrew L. Gundlach, Lisa Y. Maeng   +5 more
doaj   +2 more sources

Expression of relaxin-3 and its receptors in the hypothalamic-pituitary-ovary axis in layers and broiler breeders [PDF]

Poultry Science
Layers can regulate their feed intake and maintain well-organized ovaries. Conversely, broiler breeders are prone to overeating, leading to disorganized ovaries.
Kahina Boukherroub, Sunantha Kosonsiriluk, Pitchaya Santativongchai, Jasna Chelikandam, Lillian Ehresmann, Kristen Diehl   +5 more
doaj   +2 more sources

Molecular mechanism underlying non-discriminatory recognition of relaxin-3 by RXFP3 and RXFP4 [PDF]

Communications Biology
The human relaxin family peptide receptors RXFP3 and RXFP4 play important physiological roles through interactions with endogenous hormones, relaxin-3 and insulin-like peptide 5 (INSL5). They are implicated in certain neurological and metabolic disorders.
Yan Chen, Qingtong Zhou, Shiyu Yan, Jiahui Yan, Dehua Yang, Jian Chen, Ming-Wei Wang   +6 more
doaj   +2 more sources

Relaxin family peptide receptor 3 (RXFP3) expressing cells in the zona incerta/lateral hypothalamus augment behavioural arousal. [PDF]

J Neurochem
Relaxin family peptide receptor 3 (RXFP3) is an inhibitory G‐protein coupled receptor expressed widely throughout the mammalian brain. We show that RXFP3‐expressing cells in the mouse zona incerta and lateral hypothalamus (LH/ZIRXFP3) send efferent projections to fear and arousal‐implicated nuclei.
Richards BK, Ch'ng SS, Simon AB, Pang TY, Kim JH, Lawrence AJ, Perry CJ.   +6 more
europepmc   +2 more sources

Postnatal development of the relaxin-3 innervation of the rat medial septum [PDF]

Frontiers in Neuroscience, 2023
IntroductionThe septal area provides a rich innervation to the hippocampus regulating hippocampal excitability to different behavioral states and modulating theta rhythmogenesis.
Francisco Ros-Bernal, Isis Gil-Miravet, Jorge Lucerón, Mónica Navarro-Sánchez, Esther Castillo-Gómez, Esther Castillo-Gómez, Andrew L. Gundlach, Francisco E. Olucha-Bordonau, Francisco E. Olucha-Bordonau   +8 more
doaj   +2 more sources

Characterization of relaxin 3 and its receptors in chicken: Evidence for relaxin 3 acting as a novel pituitary hormone [PDF]

Frontiers in Physiology, 2022
Mammalian relaxin (RLN) family peptides binding their receptors (RXFPs) play a variety of roles in many physiological processes, such as reproduction, stress, appetite regulation, and energy balance.
Can Lv, Huilu Zheng, Biying Jiang, Qin Ren, Jiannan Zhang, Jiannan Zhang, Jiannan Zhang, Xin Zhang, Juan Li, Juan Li, Juan Li, Yajun Wang, Yajun Wang, Yajun Wang   +13 more
doaj   +2 more sources

Transcriptional characterization of relaxin‐3‐positive neurons in aging and Alzheimer’s disease [PDF]

Alzheimers Dement
Abstract Background Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder worldwide and is characterized by clinical symptoms that include deficits in memory and cognition. There is an urgent need to better identify the neural networks that govern cognitive processes in humans and how they are impacted by AD pathology. The brainstem
de Avila C, Nolz J, Khatri D, Uzum Z, Intorcia A, Serrano G, Beach T, Gundlach A, Mastroeni D.   +8 more
europepmc   +2 more sources