Results 41 to 50 of about 863 (134)

Understanding the interactions of relaxin-3 with its receptor RXFP3 [PDF]

, 2018
© 2018 Dr. Lilian WongRelaxin-3 is a highly conserved neuropeptide that activates the Relaxin Family Peptide Receptor 3 (RXFP3). The relaxin-3/RXFP3 neuropeptide system is involved in the modulation of stress, appetite, mood, cognition, memory and ...
Wong, Lilian
core   +1 more source

Relaxin-3/RXFP3 networks: an emerging target for the treatment of depression and other neuropsychiatric diseases?

Frontiers in Pharmacology, 2014
Animal and clinical studies of gene-environment interactions have helped elucidate the mechanisms involved in the pathophysiology of several mental illnesses including anxiety, depression and schizophrenia; and have led to the discovery of improved ...
Craig M Smith, Andrew W Walker, Ihaia T Hosken, Berenice E Chua, Cary eZhang, Mouna eHaidar, Andrew L Gundlach   +6 more
doaj   +1 more source

A promising DNA methylation signature for the triage of high-risk human papillomavirus DNA-positive women. [PDF]

PLoS ONE, 2014
High-risk human papillomavirus (hrHPV)-DNA testing is frequently performed parallel to cytology for the detection of high-grade dysplasia and cervical cancer particularly in women above 30 years of age.
Alfred Hansel, Daniel Steinbach, Christiane Greinke, Martina Schmitz, Juliane Eiselt, Cornelia Scheungraber, Mieczyslaw Gajda, Heike Hoyer, Ingo B Runnebaum, Matthias Dürst   +9 more
doaj   +1 more source

Pharmacological activation of RXFP3 is not orexigenic in C57BL/6J mice [PDF]

, 2014
The neuropeptide relaxin-3 and its cognate G-protein-coupled receptor, RXFP3, have been implicated in the control of feeding behaviour in rats. For example, relaxin-3-positive projections and RXFP3 are present within hypothalamic feeding circuits, and ...
Gundlach, Andrew L., Wade, John D., Hosken, Ihaia T., Downer, Natalie L., Chua, Berenice E., Hossain, Mohammad Akhter, Smith, Craig M.   +6 more
core   +1 more source

Relaxin-3/RXFP3 system regulates alcohol-seeking

, 2013
Fulltext embargoed for: 6 months post date of publicationRelapse and hazardous drinking represent the most difficult clinical problems in treating patients with alcohol use disorders.
Gundlach, AL, Rosengren, KJ, Lawrence, AJ, Wade, JD, Churilov, L, Ryan, PJ, Hossain, MA, Krstew, EV, Kastman, HE   +8 more
core   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors

British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Anthony P. Davenport, Eamonn Kelly, Alasdair J. Gibb, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Maria Pia Abbracchio, George R. Abraham, Alexander Agoulnik, Wayne Alexander, Khaled Al‐hosaini, Magnus Bäck, Jillian G. Baker, Nicholas M. Barnes, Ross Bathgate, Jean‐Martin Beaulieu, Annette G. Beck‐Sickinger, Maik Behrens, Kirstie A. Bennett, Kenneth E. Bernstein, Bernhard Bettler, Nigel J. M. Birdsall, Victoria A. Blaho, Pascal Bonaventure, Francois Boulay, Corinne Bousquet, Hans Bräuner‐Osborne, Andrew J. Brown, Geoffrey Burnstock, Marta Busnelli, Girolamo Caló, Vanni Caruso, Justo P. Castaño, Kevin J. Catt, Stefania Ceruti, Paul Chazot, Nan Chiang, Bice Chini, Arthur Christopoulos, Jerold Chun, Antonia Cianciulli, Olivier Civelli, Lucie H. Clapp, Réjean Couture, Helen M. Cox, Zsolt Csaba, Claes Dahlgren, Frank M. Dautzenberg, Gordon Dent, Steven D. Douglas, Pascal Dournaud, Margarita L. Dubocovich, Satoru Eguchi, Emanuel Escher, Edward J. Filardo, Tung Fong, Huamei Fu Forsman, Marta Fumagalli, Raul R. Gainetdinov, Michael L. Garelja, Marc de Gasparo, Florence Gbahou, Craig Gerard, Marvin Gershengorn, Michelle Glass, David E. Gloriam, Fernand Gobeil, Theodore L. Goodfriend, Cyril Goudet, Lukas Grätz, Karen J. Gregory, Christian Gruber, Andrew L. Gundlach, Jörg Hamann, Julien Hanson, Deborah S. Hartman, Richard L. Hauger, Debbie L. Hay, Akos Heinemann, Laura Heitman, Deron R. Herr, Morley D. Hollenberg, Nicholas D. Holliday, Birgitte Holst, Mastgugu Horiuchi, Daniel Hoyer, László Hunyady, Ahsan Husain, Adriaan P. IJzerman, Tadashi Inagami, Paul A. Insel, Kenneth A. Jacobson, Laura H. Jacobson, Robert T. Jensen, Ralf Jockers, Deepa Jonnalagadda, Sadashiva Karnik, Klemens Kaupmann, Jacqueline Kemp, Charles Kennedy, Yasuyuki Kihara, Julia Kinsolving, Takio Kitazawa, Pawel Kozielewicz, Hans‐Jürgen Kreienkamp, Jyrki P. Kukkonen, Luxmichan Laishram, Tobias Langenhan, Christopher J. Langmead, Dan Larhammar, Katie Leach, Davide Lecca, John D. Lee, Susan E. Leeman, Jérôme Leprince, Rob Leurs, Xaria X. Li, Ines Liebscher, Stephen J. Lolait, Amelie Lupp, Robyn Macrae, Janet J. Maguire, Davide Malfacini, Maurice Manning, Davide Marangon, Kirill Martemyanov, Jean Mazella, Craig A. McArdle, Shlomo Melmed, Martin C. Michel, Laurence J. Miller, Vincenzo Mitolo, Bernard Mouillac, Christa E. Müller, Philip M. Murphy, Jean‐Louis Nahon, Richard R. Neubig, Tony Ngo, Xavier Norel, Duuamene Nyimanu, Anne‐Marie O’Carroll, Stefan Offermanns, Maria Antonietta Panaro, Marc Parmentier, Nicole Perry‐Hauser, Roger G. Pertwee, Jean‐Philippe Pin, Eric R. Prossnitz, Helena Chengxue Qin, Mark Quinn, Stefano Raffaele, Rithwik Ramachandran, Manisha Ray, Rainer K. Reinscheid, Alejandro Romeral Buzón, Philippe Rondard, Mette M. Rosenkilde, G. Enrico Rovati, Chiara Ruzza, Gareth J. Sanger, Nicole Scholz, Torsten Schöneberg, Gunnar Schulte, Stefan Schulz, Deborah L. Segaloff, Charles N. Serhan, Arun K. Shukla, Khuraijam Dhanachandra Singh, Craig M. Smith, Nicola J. Smith, Claudia Stäubert, Leigh A. Stoddart, Yukihiko Sugimoto, Roger Summers, Valerie P. Tan, David M. Thal, Walter ( Wally) Thomas, Pieter B. M. W. M. Timmermans, Kalyan Tirupula, Lawrence Toll, Giovanni Tulipano, Hamiyet Unal, Thomas Unger, Celine Valant, Patrick Vanderheyden, David Vaudry, Hubert Vaudry, Joseph G. Verbalis, Jean‐Pierre Vilardaga, Christopher S. Walker, Ji Ming Wang, Donald T. Ward, Hans‐Jürgen Wester, Gary B. Willars, Tom Lloyd Williams, Trent M. Woodruff, Huixian Wu, Cheng Yang, Chengcan Yao, Richard D. Ye, Nathan Zaidman   +206 more
wiley   +1 more source

DNA methylation signatures of cervical pre‐invasive and invasive disease: An epigenome‐wide association study

International Journal of Cancer, Volume 157, Issue 2, Page 305-316, 15 July 2025.
What's new? Cervical cancer screening programmes could benefit from an accurate triage test for human papillomavirus‐positive women based on self‐sampling. This epigenome‐wide association study examined a large number of cervical cancers and cervical intraepithelial neoplasias grade 3 (CIN3) compared to controls using the 850 k EPIC methylation array ...
Sarah J. Bowden, Barbara Bodinier, Maria Paraskevaidi, Ilkka Kalliala, Maria Nasioutziki, Laura Burney Ellis, Ruben Colindres Zuehlke, James M. Flanagan, Maria Kyrgiou, Marc Chadeau‐Hyam   +9 more
wiley   +1 more source

Advances in cervical cancer: current insights and future directions

Cancer Communications, Volume 45, Issue 2, Page 77-109, February 2025.
Abstract In alignment with the World Health Organization's strategy to eliminate cervical cancer, substantial progress has been made in the treatment of this malignancy. Cervical cancer, largely driven by human papillomavirus (HPV) infection, is considered preventable and manageable because of its well‐established etiology.
Miaochun Xu, Canhui Cao, Peng Wu, Xiaoyuan Huang, Ding Ma   +4 more
wiley   +1 more source

Research progress of DNA methylation in the screening of cervical cancer and precancerous lesions

Interdisciplinary Medicine, Volume 3, Issue 1, January 2025.
Cervical cancer, driven by persistent high risk human papillomavirus (HPV) infection, is a major health threat to women. Traditional screening methods such as cytology and HPV testing have limitations. The World Health Organization suggests DNA methylation testing as a promising new method.
Yunge Wang, Xueping Ma, Tao Zhang, Lingfei Wang, Yunlong Liu, Guohua Zhou, Haiping Wu   +6 more
wiley   +1 more source

Phylogenetic reconstruction of the evolutionary relationship among vertebrate RXFP3/4 protein sequences.

, 2012
Reconstruction performed as outlined in methods with G = 0.91 and I = n/a. Numbers at each node indicate the bootstrap values (only values exceeding 50% shown).
Sara Good (176377), Sergey Yegorov (176376)   +1 more
core   +1 more source