Results 61 to 70 of about 863 (134)

Neuroanatomical basis for the anti-nociceptive role of the relaxin-3/RXFP3 peptidergic system

International audienceAffecting around 10% of world population, chronic pain and its related psychiatric comorbidities (e.g. anxiety and depression) are major health issues.
Escoffier, Solène, Dhellemmes, Thibault, Hossain, Akhter, Gundlach, Andrew, Landry, Marc   +4 more
core   +1 more source

Performance of a DNA methylation marker panel using liquid-based cervical scrapes to detect cervical cancer and its precancerous stages

BMC Cancer, 2018
Background A change of cervical cancer screening algorithms to an HPV-based screening setting is discussed in many countries, due to higher sensitivity of HPV testing compared to cytology.
Martina Schmitz, Kristin Eichelkraut, Dana Schmidt, Ilona Zeiser, Ziad Hilal, Zena Tettenborn, Alfred Hansel, Hans Ikenberg   +7 more
doaj   +1 more source

Targeting G protein‐coupled receptors for heart failure treatment

British Journal of Pharmacology, Volume 181, Issue 14, Page 2270-2286, July 2024.
Heart failure remains a leading cause of morbidity and mortality worldwide. Current treatment for patients with heart failure include drugs targeting G protein‐coupled receptors such as β‐adrenoceptor antagonists (β‐blockers) and angiotensin II type 1 receptor antagonists (or angiotensin II receptor blockers).
Bui San Thai, Ling Yeong Chia, Anh T. N. Nguyen, Chengxue Qin, Rebecca H. Ritchie, Dana S. Hutchinson, Andrew Kompa, Paul J. White, Lauren T. May   +8 more
wiley   +1 more source

Effect of relaxin‐3 on Kiss‐1, gonadotropin‐releasing hormone, and gonadotropin subunit gene expression

Reproductive Medicine and Biology, 2019
Purpose Relaxin‐3 is a hypothalamic neuropeptide that belongs to the insulin superfamily. We examined whether relaxin‐3 could affect hypothalamic Kiss‐1, gonadotropin‐releasing hormone (GnRH), and pituitary gonadotropin subunit gene expression.
Haruhiko Kanasaki, Tuvshintugs Tumurbaatar, Zolzaya Tumurgan, Aki Oride, Hiroe Okada, Satoru Kyo   +5 more
doaj   +1 more source

Aberrant PRDM2 methylation as an early event in serrated lesions destined to evolve into microsatellite‐instable colorectal cancers

The Journal of Pathology: Clinical Research, Volume 10, Issue 2, March 2024.
Abstract Up to 30% of colorectal cancers (CRCs) develop from sessile serrated lesions (SSLs). Within the serrated neoplasia pathway, at least two principally distinct oncogenetic routes exist generating microsatellite‐stable and microsatellite‐instable CRCs, respectively.
David EFWM van Toledo, Arne GC Bleijenberg, Andrea Venema, Mireille J de Wit, Susanne van Eeden, Gerrit A Meijer, Beatrice Carvalho, Evelien Dekker, Peter Henneman, Joep EG IJspeert, Carel JM van Noesel   +10 more
wiley   +1 more source

Glia‐specific expression of neuropeptide receptor Lgr4 regulates development and adult physiology in Drosophila

Journal of Neuroscience Research, Volume 102, Issue 1, January 2024.
Lgr4 in glial cells plays an essential part in development, adult behavioral patterns, and lifespan. Within the LGR family, the impairment of development is only attributable to the decrease in Lgr4 in glia. And adult‐specific knockdown of Lgr4 in glia will reduce locomotion, male reproductive success, and animal longevity.
Hongyu Miao, Yanan Wei, Seung Gee Lee, Zekun Wu, Jasdeep Kaur, Woo Jae Kim   +5 more
wiley   +1 more source

Altered relaxin family receptors RXFP1 and RXFP3 in the neocortex of depressed Alzheimer's disease patients

, 2016
Rationale: The G-protein-coupled relaxin family receptors RXFP1 and RXFP3 are widely expressed in the cortex and are involved in stress responses and memory and emotional processing.
Koh, Shu Qing, Guadagna, Simone, Esiri, Margaret M., Wong, Peter T H, Dawe, Gavin S., Chen, Christopher P., Lai, Mitchell K P, Lee, Jasinda H., Francis, Paul T.; id_orcid   +8 more
core   +1 more source

Relaxin-3 receptor (RXFP3) mediated modulation of central respiratory activity

, 2020
The neuropeptide, relaxin‐3, is expressed by pontine nucleus incertus (NI) neurons. Relaxin‐3 and synthetic agonist peptides modulate arousal and cognitive processes via activation of the ...
Hossain, M, Furuya, W, Gundlach, A, Dutschmann, M, Dhingra, R   +4 more
core   +1 more source

Relaxin-3/RXFP3 system modulation of anxiety and social behavior in the rat: chronic RXFP3 activation in the hippocampus and amygdala

, 2018
© 2017 Dr. Valeria RytovaRelaxin-3 is an evolutionary conserved neuropeptide highly expressed by γ-aminobutyric acid (GABA) projection neurons in hindbrain regions including the nucleus incertus, which acts via its cognate Gi/o-protein-coupled receptor ...
Rytova, Valeria
core   +1 more source

Relaxin family peptide receptor 3- RXFP3 (GPCR135)

, 2008
Relaxin family peptide receptor 3- RXFP3 ...
A Gundlach (13646296), Craig Smith (13065255)   +1 more
core