Results 51 to 60 of about 863 (134)

Food Allergy Genetics and Epigenetics: A Review of Genome‐Wide Association Studies

Allergy, Volume 80, Issue 1, Page 106-131, January 2025.
ABSTRACT In this review, we provide an overview of food allergy genetics and epigenetics aimed at clinicians and researchers. This includes a brief review of the current understanding of genetic and epigenetic mechanisms, inheritance of food allergy, as well as a discussion of advantages and limitations of the different types of studies in genetic ...
Aleix Arnau‐Soler, Bénédicte L. Tremblay, Yidan Sun, Anne‐Marie Madore, Mathieu Simard, Elin T. G. Kersten, Ahla Ghauri, Ingo Marenholz, Thomas Eiwegger, Elinor Simons, Edmond S. Chan, Kari Nadeau, Vanitha Sampath, Bruce D. Mazer, Susan Elliott, Christine Hampson, Lianne Soller, Andrew Sandford, Philippe Begin, Jennie Hui, Bethany F. Wilken, Jennifer Gerdts, Adrienn Bourkas, Anne K. Ellis, Denitsa Vasileva, Ann Clarke, Aida Eslami, Moshe Ben‐Shoshan, David Martino, Denise Daley, Gerard H. Koppelman, Catherine Laprise, Young‐Ae Lee, Yuka Asai   +33 more
wiley   +1 more source

Relaxin-3/RXFP3 signalling control of alcohol and sucrose consumption: Studies in Rxfp3 knockout mice

, 2015
© 2015 Dr. Andrew Walter WalkerRelaxin-3 is a highly conserved neuropeptide with putative roles in behavioural arousal, motivation and stress responses. Within the rodent brain, relaxin-3 is primarily expressed by neurons in the pontine nucleus incertus (
Walker, Andrew Walter
core   +1 more source

Characterization and stress induced modulations of RXFP3+ neurons in the mouse BNST [PDF]

, 2017
© 2017 Jingjing FuStress induced relapse and stressful emotional responses occurring during drug withdrawal are common problems for drug addicts. The relaxin-3/relaxin family peptide receptor 3 (RXFP3) system modulates stress responses and reward seeking
Fu, Jingjing Jr
core   +1 more source

Genomic responses to climatic challenges in beef cattle: A review

Animal Genetics, Volume 55, Issue 6, Page 854-870, December 2024.
Abstract Climate change is a major concern for the near future and for livestock breeding. Cattle breeding, due to its greenhouse gas emissions, is one of the most implicated industries. Consequently, the main future goals are to breed animals resilient to climate change, with the aim of lowering the livestock impact on the environment and selecting ...
Daniele Colombi, Francesco Perini, Stefano Bettini, Salvatore Mastrangelo, Fabio Abeni, Giuseppe Conte, Donata Marletta, Martino Cassandro, Umberto Bernabucci, Roberta Ciampolini, Emiliano Lasagna   +10 more
wiley   +1 more source

Performance of a methylation specific real-time PCR assay as a triage test for HPV-positive women

Clinical Epigenetics, 2017
Background HPV DNA testing as a primary screening marker is being implemented in several countries. Due to the high HPV prevalence in the screening population, effective triage strategies for HPV-positive cases are required.
Martina Schmitz, Kristina Wunsch, Heike Hoyer, Cornelia Scheungraber, Ingo B. Runnebaum, Alfred Hansel, Matthias Dürst   +6 more
doaj   +1 more source

Addressing dispersion in mis‐measured multivariate binomial outcomes: A novel statistical approach for detecting differentially methylated regions in bisulfite sequencing data

Statistics in Medicine, Volume 43, Issue 20, Page 3899-3920, 10 September 2024.
Motivated by a DNA methylation application, this article addresses the problem of fitting and inferring a multivariate binomial regression model for outcomes that are contaminated by errors and exhibit extra‐parametric variations, also known as dispersion.
Kaiqiong Zhao, Karim Oualkacha, Yixiao Zeng, Cathy Shen, Kathleen Klein, Lajmi Lakhal‐Chaieb, Aurélie Labbe, Tomi Pastinen, Marie Hudson, Inés Colmegna, Sasha Bernatsky, Celia M. T. Greenwood   +11 more
wiley   +1 more source

Indole-Containing Amidinohydrazones as Nonpeptide Dual RXFP3/4 Agonists: Synthesis, StructureActivity Relationship and Molecular Modeling Studies

, 2021
The central relaxin-3/RXFP3 system plays important roles in stress responses, feeding, and motivation for reward. However, exploration of its therapeutic applications has been hampered by the lack of small molecule ligands and the cross-activation of ...
Chang-Guo Zhan, Alexander H. Williams (9444334), Dongliang Guan, Kelly M. Mathews (4341682), Ann M. Decker (1322412), Alexander H. Williams, Md Toufiqur Rahman, Chunyang Jin (1327155), Kelly M. Mathews, Chang-Guo Zhan (147266), Ann M. Decker, Dongliang Guan (4731594), Vineetha Vasukuttan (5202884), Elaine A. Gay, Chunyang Jin, Md Toufiqur Rahman (9655855), Elaine A. Gay (1336752), Vineetha Vasukuttan   +17 more
core   +1 more source

Cumulative phylogenetic, sequence and structural analysis of Insulin superfamily proteins provide unique structure‐function insights

Molecular Informatics, Volume 43, Issue 9, September 2024.
Abstract The insulin superfamily proteins (ISPs), in particular, insulin, IGFs and relaxin proteins are key modulators of animal physiology. They are known to have evolved from the same ancestral gene and have diverged into proteins with varied sequences and distinct functions, but maintain a similar structural architecture stabilized by highly ...
Shrilakshmi Sheshagiri Rao, Shankar V. Kundapura, Debayan Dey, Chandrasekaran Palaniappan, Kanagaraj Sekar, Ananda Kulal, Udupi A. Ramagopal   +6 more
wiley   +1 more source

The role of relaxin-3/RXFP3 signalling in anxiety, stress and feeding in the mouse [PDF]

, 2017
© 2017 Dr. Cary ZhangRelaxin-3 is a neuropeptide expressed by neurons of the brainstem nucleus incertus (NI). Relaxin-3 signalling via its cognate receptor, RXFP3, is proposed to be involved in the neuromodulatory control of arousal- and stress-related ...
Zhang, Cary
core   +1 more source

Functional crosstalk between angiotensin receptors (types 1 and 2) and relaxin family peptide receptor 1 (RXFP1): Implications for the therapeutic targeting of fibrosis

British Journal of Pharmacology, Volume 181, Issue 14, Page 2302-2318, July 2024.
Class A, rhodopsin‐like, G‐protein‐coupled receptors (GPCRs) are by far the largest class of GPCRs and are integral membrane proteins used by various cells to convert extracellular signals into intracellular responses. Initially, class A GPCRs were believed to function as monomers, but a growing body of evidence has emerged to suggest that these ...
Chrishan S. Samuel, Yifang Li, Yan Wang, Robert E. Widdop   +3 more
wiley   +1 more source