Results 31 to 40 of about 863 (134)
C-terminus of the B-chain of relaxin-3 is important for receptor activity. [PDF]
PLoS ONE, 2013 Human relaxin-3 is a neuropeptide that is structurally similar to human insulin with two chains (A and B) connected by three disulfide bonds. It is expressed primarily in the brain and has modulatory roles in stress and anxiety, feeding and metabolism ...
Fazel Shabanpoor +3 more
doaj +1 more source
Development of a long‐acting relaxin analogue, LY3540378, for treatment of chronic heart failure
British Journal of Pharmacology, Volume 180, Issue 15, Page 1965-1980, August 2023., 2023 Abstract Background and Purpose Chronic heart failure, a progressive disease with limited treatment options currently available, especially in heart failure with preserved ejection fraction (HFpEF), represents an unmet medical need as well as an economic burden.
Petra Verdino +29 more
wiley +1 more source
Cancer epigenetics in clinical practice
CA: A Cancer Journal for Clinicians, Volume 73, Issue 4, Page 376-424, July/August 2023., 2023 Abstract Cancer development is driven by the accumulation of alterations affecting the structure and function of the genome. Whereas genetic changes disrupt the DNA sequence, epigenetic alterations contribute to the acquisition of hallmark tumor capabilities by regulating gene expression programs that promote tumorigenesis.
Veronica Davalos, Manel Esteller
wiley +1 more source
Development of Relaxin-3 Agonists and Antagonists Based on Grafted Disulfide-Stabilized Scaffolds
Frontiers in Chemistry, 2020 Relaxin-3 is a neuropeptide with important roles in metabolism, arousal, learning and memory. Its cognate receptor is the relaxin family peptide-3 (RXFP3) receptor.
Han Siean Lee +7 more
doaj +1 more source
Gut peptide regulation of food intake – evidence for the modulation of hedonic feeding
The Journal of Physiology, Volume 600, Issue 5, Page 1053-1078, 1 March 2022., 2022 Abstract figure legend: The gastrointestinal tract produces a range of peptides that regulate appetite and body weight. Key peptides are highlighted here. These gut peptides are secreted from enteroendocrine cells in response to nutrient intake and communicate with the brain directly, via the bloodstream, and indirectly, via the vagus nerve, to alter ...
Orla R. M. Woodward +3 more
wiley +1 more source
Current Issues in Molecular Biology, 2022 The role of differentially methylated regions (DMRs) in nonalcoholic fatty liver disease (NAFLD) is unclear. This study aimed to identify the role of DMR in NAFLD development and progression using the Korean Genome and Epidemiology Study (KoGES) cohort ...
Young Kyung Ko +4 more
doaj +1 more source
Developmental expression pattern of two zebrafish rxfp3 paralogue genes
, 2013 In mammals, the RXFP3 is the cognate receptor of the relaxin-3 peptide (RLN3). In teleosts, many different orthologue genes for RXFP3 are present. In particular, two paralogue genes, rxfp3-2a and rxfp3-2b, likely encode the receptors for the Rln3a ...
1 Rosanna del Gaudio Giovanni Iazzetti +5 more
core +2 more sources
Development of a selective agonist for relaxin family peptide receptor 3
Scientific Reports, 2017 Relaxin family peptides perform a variety of biological functions by activating four G protein-coupled receptors, namely RXFP1–4. Among these receptors, RXFP3 lacks a specific natural or synthetic agonist at present.
Dian Wei +7 more
doaj +1 more source
Discovery and Characterization of the First Nonpeptide Antagonists for the Relaxin-3/RXFP3 System
, 2022 The neuropeptide relaxin-3/RXFP3 system is involved in many important physiological processes such as stress responses, appetite control, and motivation for reward. To date, pharmacological studies of RXFP3 have been limited to peptide ligands.
Elaine A. Gay (12574844) +6 more
core +2 more sources
Frontiers in Endocrinology, 2013 Complex neural circuits within the hypothalamus that govern essential autonomic processes and associated behaviors signal using amino acid and monoamine transmitters and a variety of neuropeptide (hormone) modulators, often via G-protein coupled ...
Despina E Ganella +2 more
doaj +1 more source