Differential Level of RXFP3 Expression in Dopaminergic Neurons Within the Arcuate Nucleus, Dorsomedial Hypothalamus and Ventral Tegmental Area of RXFP3-Cre/tdTomato Mice [PDF]
Frontiers in Neuroscience, 2021 RXFP3 (relaxin-family peptide 3 receptor) is the cognate G-protein-coupled receptor for the neuropeptide, relaxin-3. RXFP3 is expressed widely throughout the brain, including the hypothalamus, where it has been shown to modulate feeding behavior and ...
Lara M. Voglsanger +10 more
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GABAergic Neurons in the Rat Medial Septal Complex Express Relaxin-3 Receptor (RXFP3) mRNA [PDF]
Frontiers in Neuroanatomy, 2018 The medial septum (MS) complex modulates hippocampal function and related behaviors. Septohippocampal projections promote and control different forms of hippocampal synchronization.
Hector Albert-Gascó +8 more
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Septal GABA and Glutamate Neurons Express RXFP3 mRNA and Depletion of Septal RXFP3 Impaired Spatial Search Strategy and Long-Term Reference Memory in Adult Mice [PDF]
Frontiers in Neuroanatomy, 2019 Relaxin-3 is a highly conserved neuropeptide abundantly expressed in neurons of the nucleus incertus (NI), which project to nodes of the septohippocampal system (SHS) including the medial septum/diagonal band of Broca (MS/DB) and dorsal hippocampus, as ...
Mouna Haidar +14 more
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Relaxin-3 receptor (RXFP3) signalling mediates stress-related alcohol preference in mice. [PDF]
PLoS ONE, 2015 Stressful life events are causally linked with alcohol use disorders (AUDs), providing support for a hypothesis that alcohol consumption is aimed at stress reduction. We have previously shown that expression of relaxin-3 mRNA in rat brain correlates with
Andrew W Walker +6 more
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In vitro pharmacological characterization of RXFP3 allosterism: an example of probe dependency. [PDF]
PLoS ONE, 2012 Recent findings suggest that the relaxin-3 neural network may represent a new ascending arousal pathway able to modulate a range of neural circuits including those affecting circadian rhythm and sleep/wake states, spatial and emotional memory, motivation
Lily Alvarez-Jaimes +7 more
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Multiomics-based analysis of key genes, metabolites and pathways unveils mechanism associated with social rank in Chickens [PDF]
Poultry ScienceSocial rank plays a crucial role in shaping physiological, psychological and immune responses in animals. Our previous study found that gut microbes and short-chain fatty acids as well as brain neurotransmitters are involved with the mechanism of social ...
Mengqiao Zhao +6 more
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Detection of DNA Methylation in Gene Loci ASTN1, DLX1, ITGA4, RXFP3, SOX17, and ZNF671 for Diagnosis of Cervical Cancer [PDF]
Cancer Management and Research, 2023 Chunli Fan,1,2,* Quanfu Ma,1,2,* Xufeng Wu,2 Xuan Dai,2 Qiuzi Peng,2 Hongning Cai1,2 1Department of Scientific Research and Teaching Management Department, Maternal and Child Health Hospital of Hubei Province, Wuhan, 430070, People’s Republic of ...
Fan C, Ma Q, Wu X, Dai X, Peng Q, Cai H
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Promoter hypermethylation analysis of host genes in cervical intraepithelial neoplasia and cervical cancers on histological cervical specimens [PDF]
BMC Cancer, 2023 Background DNA methylation is an essential factor in the progression of cervical intraepithelial neoplasia (CIN) to cervical cancer. The aim was to investigate the diagnostic value provided by methylation biomarkers of six tumor suppressor genes (ASTN1 ...
Liye Shi +10 more
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Analysis of the triage value of multigene methylation testing for CIN2 + in hrHPV-positive patients [PDF]
Infectious Agents and CancerObjective To assess the triage value of multigene methylation testing for cervical intraepithelial neoplasia 2 and above (CIN2+) in high-risk human papillomavirus (hrHPV) positive patients.
Caiyun Lin +3 more
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Triage of women with a positive HPV DNA test: evaluating a DNA methylation panel for detecting cervical intraepithelial neoplasia grade 3 and cervical cancer in cervical cytology samples [PDF]
BMC CancerBackground Efficient triage of high-risk human papillomavirus (hrHPV)-positive women is essential to avoid unnecessary referrals and overtreatment. This study evaluates the diagnostic accuracy of the commercially available DNA methylation panel, GynTect®
Yifei Ren +5 more
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