Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3 [PDF]
Frontiers in Endocrinology, 2013 Relaxin-3 is a highly conserved neuropeptide in vertebrate species and binds to the Class A G protein-coupled receptor RXFP3. Relaxin-3 is involved in a wide range of behaviours, including feeding, stress responses, arousal and cognitive processes and ...
Ross eBathgate +10 more
doaj +2 more sources
Performance of a six-methylation-marker assay in predicting LEEP specimen histology results of cervical HSIL patients: a retrospective study [PDF]
BMC CancerBackground Discrepancies have been found between preoperative colposcopic biopsy results and histology results of loop electrical excision procedure (LEEP) specimens.
Ruolan Wu +7 more
doaj +2 more sources
Synaptic Structure and Transcriptomic Profiling of Reward and Sensory Brain Areas in Male Mice of Fentanyl Addiction [PDF]
Substance Abuse and RehabilitationJunli Feng,1,* Ningsi Xu,1,* Linhua Wang,2 Haixing Wang,3 Yi Zhou,3 Qing Shen4,5 1Collaborative Innovation Center of Seafood Deep Processing, Zhejiang Province Joint Key Laboratory of Aquatic Products Processing, Institute of Seafood, Zhejiang ...
Feng J +5 more
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Targeting the relaxin-3/RXFP3 system: a patent review for the last two decades [PDF]
Expert Opinion on Therapeutic PatentsChunyang Jin, Md Toufiqur Rahman
exaly +2 more sources
FACETS, 2021 The effect of treatment with human relaxins on cell death was studied in oxygen- and glucose-deprived brain slices. In addition, involvement of nitric oxide and the relaxin receptor, RXFP3, was studied.
Nicholas P. DeAdder +2 more
doaj +1 more source
Exploring the Use of Helicogenic Amino Acids for Optimising Single Chain Relaxin-3 Peptide Agonists
Biomedicines, 2020 Relaxin-3 is a highly conserved two-chain neuropeptide that acts through its endogenous receptor the Relaxin Family Peptide-3 (RXFP3) receptor. The ligand/receptor system is known to modulate several physiological processes, with changes in food intake ...
Han Siean Lee +6 more
doaj +1 more source
Relaxin-3 Innervation From the Nucleus Incertus to the Parahippocampal Cortex of the Rat
Frontiers in Neuroanatomy, 2021 Spatial learning and memory processes depend on anatomical and functional interactions between the hippocampus and the entorhinal cortex. A key neurophysiological component of these processes is hippocampal theta rhythm, which can be driven from ...
Cristina García-Díaz +10 more
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History of key regulatory peptide systems and perspectives for future research
Journal of Neuroendocrinology, Volume 35, Issue 11, November 2023., 2023 The history of the International Regulatory Peptide Society and RegPep symposia reflects the evolution of regulatory peptide discovery since 1902, which is exemplified by scientific works of Viktor Mutt, Wylie W. Vale Jr and Rolf Håkanson and research on corticotropin‐releasing factor (CRF), enterochromaffin‐like (ECL) cells, cholecystokinin (CCK ...
Duan Chen +4 more
wiley +1 more source
Frontiers in Neuroanatomy, 2021 Telencephalic cognitive and emotional circuits/functions are strongly modulated by subcortical inputs. The main focus of past research on the nature of this modulation has been on the widespread monoamine projections to the telencephalon.
Isis Gil-Miravet +8 more
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The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
British Journal of Pharmacology, Volume 180, Issue S2, Page S23-S144, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander +165 more
wiley +1 more source