Results 81 to 90 of about 59,932 (250)

Comparative outcome analysis of hydroxychloroquine/chloroquine, remdesivir and standard of care treatment against COVID-19 infection [PDF]

, 2020
This study aimed to compare the efficacy and safety of hydroxychloroquine/chloroquine (HCQ/CQ), remdesivir and standard of care treatment (SOC) in patients with nCoV-19 based on the RCTs available in the literature.
Kumar, Vikas, Mahato, Sumit Kumar
core   +2 more sources

Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry [PDF]

, 2022
Background: Large cohort studies of patients with COVID-19 treated with remdesivir have reported improved clinical outcomes, but data on older patients are scarce.
Abella Vázquez, Lucy, Areses Manrique, Maria, Asensi, Victor, Cobos Palacios, Lidia, Cossio Tejido, Santiago de, Díez García, Luis Felipe, Guisado Vasco, Pablo, Gómez Huelgas, Ricardo, Lumbreras Bermejo, Carlos, López Carmona, María Dolores, López Sampalo, Almudena, Martinez Cilleros, Carmen, Martinez Pascual, Angeles, Martín Escalante, María Dolores, Martínez Gonzalez, Angel Luís, Muiño Miguez, Antonio, Ramos Rincon, Jose Manuel, Ripper, Carlos Jorge, Rubio Rivas, Manuel, Taboada Martínez, María Luisa, The Semi-covid-19 Network, Tuñón de Almeida, Carlota   +21 more
core   +1 more source

Remdesivir for the Treatment of COVID-19: A Systematic Review of the Literature [PDF]

, 2020
In March 2020, the World Health Organization declared the spread of SARS-CoV-2 a global pandemic. To date, coronavirus disease-2019 (COVID-19) has spread to over 200 countries, leading to over 1.6 million cases and over 99,000 deaths. Given that there is
Aly, Besma, Baron, David A., Blodget, Emily, Hashemi, Areio, Kouyoumjian, Sarkis, Musa, Arif, Pendi, Kasim, Stevens, Susan, Warbasse, Elizabeth, Yousif, Jenna   +9 more
core  

Role of Remdesivir therapy in COVID-19 patients: a systematic review and meta-analysis [PDF]

, 2022
The rapid global spread of corona virus disease has created an adversity for the scientific community in managing the disease with appropriate therapeutic measures.
Muthiah, Aravind, Perumal, Shridharan, Srikumar, Shabarini   +2 more
core   +2 more sources

Activation of the urotensin-II receptor by remdesivir induces cardiomyocyte dysfunction

Communications Biology, 2023
Remdesivir is an antiviral drug used for COVID-19 treatment worldwide. Cardiovascular side effects have been associated with remdesivir; however, the underlying molecular mechanism remains unknown.
Akiko Ogawa, Seiya Ohira, Yuri Kato, Tatsuya Ikuta, Shota Yanagida, Xinya Mi, Yukina Ishii, Yasunari Kanda, Motohiro Nishida, Asuka Inoue, Fan-Yan Wei   +10 more
doaj   +1 more source

Precipitating factors of bradycardia after remdesivir administration: ICU admission and cutoff value for declining heart rate

Journal of Microbiology, Immunology and Infection, 2023
Background: Despite increasing concerns about the association between remdesivir and bradycardia in severe coronavirus disease 2019 (COVID-19) patients receiving remdesivir, information on its clinical course and precipitating factors is limited. Our aim
Yan-Zuo Chen, Ming-Shen Lin, Yi-Ping Lin, Yi-Zhan Liu, Chia-Jui Yang   +4 more
doaj   +1 more source

Brief Summary of Potential SARS-CoV-2 Prophylactic and Treatment Drugs in the Emergency Department [PDF]

, 2020
As of March 30th, 2020 there were 161,807 total cases and 2,953 total deaths of SARS-CoV-2 in the United States, with the number of cases expected to rise.
Brown, Cortlyn, Coralic, Zlatan, Noble, Jeanne   +2 more
core  

Challenges and recent progress in drug discovery for tropical diseases [PDF]

, 2018
Infectious tropical diseases have a huge effect in terms of mortality and morbidity, and impose a heavy economic burden on affected countries. These diseases predominantly affect the world’s poorest people.
A Guidi, A Hoerauf, AF Francisco, AK Kakkar, AK Njamnshi, AN Cowell, B Amadi, B Baragana, B Blasco, B Wahid, Beatriz Baragaña, CA Fux, CD Huston, CE Barry III, CE Coltart, D Sissoko, DA Lamprecht, DG Brown, DI Stanisic, DM Plouffe, DS Shepard, DT Hoagland, E Bushell, E Chatelain, E Chatelain, E Check Hayden, E Tacconelli, E Torreele, E Wit de, F Josephson, F Macintyre, FJ Sanchez-Valdez, FX Blanc, G Priotto, G-Finder, H Myllymaki, Hotez, I Angulo-Barturen, I Kramnik, I Molina, Ian H. Gilbert, ID Olaru, IPFMA, J Keiser, J Liu, J Whitehorn, JG Kublin, JN Burrows, JP Sarathy, JR Perfect, JS McCarthy, JS McCarthy, K Awadzi, K Basile, KH Mayer, KK Irwin, KL Kotloff, L Conteh, LJ Zhan, LL Silver, M Lee, M Matsumoto, MA Hulverson, Manu De Rycker, MB Jimenez-Diaz, MC Field, MC Pawlowic, MF Fromm, ML Ang, ML Hovlid, MS Love, MY Lim, N Ford, N Gyawali, N Lander, N Woodford, NA Meanwell, NJ White, NJ White, NJ White, NR Mansour, OP Singh, P Buscher, P Horvath, P Steinmann, PG Wyatt, PJ Hotez, R Rajasingham, R Taylor, RT Jacobs, S Baker, S Brooker, S Khare, S Sayasone, SA Mikolajczak, SD Pion, SH Xiao, SM Hammer, Suzanne L. Duce, T Paquet, TF Koning-Ward de, TK Warren, TN Wells, U Klarmann-Schulz, UH Manjunatha, UH Manjunatha, V Boldescu, V Mesu, VK Wong, W Checkley, W Moser, W Moser, W Zheng, Warren, World Health Organization, X Li, Y Debing, Y Wang   +117 more
core   +2 more sources

Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19

ACS Central Science, 2020
The global pandemic of SARS-CoV-2, the causative viral pathogen of COVID-19, has driven the biomedical community to action—to uncover and develop antiviral interventions.
R. Eastman, Jacob S. Roth, K. Brimacombe, A. Simeonov, M. Shen, S. Patnaik, M. Hall   +6 more
semanticscholar   +1 more source

Remdesivir and its antiviral activity against COVID-19: A systematic review

Clinical Epidemiology and Global Health, 2021
Background: The aim of this study was to summarize the antiviral activities of remdesivir against SARS-CoV-2, the causative agent of COVID-19. Methods: Available publications were systematically explored on some databases and gray literature was examined.
Andri Frediansyah, Firzan Nainu, Kuldeep Dhama, Mudatsir Mudatsir, Harapan Harapan   +4 more
doaj   +1 more source