Results 111 to 120 of about 41,992 (300)
Unraveling the Role of Ensheathing Cells and Perineural Fibroblasts in Olfactory Neurogenesis
Glia, EarlyView.OECs are similar to satellite glial cells. OECs react to neuronal injury by promoting lipid metabolism, but do not proliferate. OECs reduce gap junctions upon neuronal injury. Perineural fibroblasts also contribute to the injury response. ABSTRACT During development and following injury‐induced neurogenesis, olfactory ensheathing cells (OECs) envelope ...
Katja Senf +3 more
wiley +1 more source
Effect of glial cells on remyelination after spinal cord injury
Neural Regeneration Research, 2017 Remyelination plays a key role in functional recovery of axons after spinal cord injury. Glial cells are the most abundant cells in the central nervous system. When spinal cord injury occurs, many glial cells at the lesion site are immediately activated,
Hai-feng Wang +12 more
doaj +1 more source
EEF1A1 deacetylation enables transcriptional activation of remyelination
Nature Communications, 2020 The molecular mechanisms regulating remyelination are unclear. Here, the authors show that promoting deacetylation of eEF1A1 prevents the translocation of Sox10 outside the nucleus, contributing to maintaining the expression of Sox10 target genes and ...
Mert Duman +14 more
doaj +1 more source
Therapeutic laquinimod treatment decreases inflammation, initiates axon remyelination, and improves motor deficit in a mouse model of multiple sclerosis. [PDF]
, 2013 BackgroundTherapeutic strategies that induce effective neuroprotection and enhance intrinsic repair mechanisms are central goals for future treatment of multiple sclerosis (MS), as well as other diseases.
Hannsun, Gemmy +9 more
core
Oligodendrogenesis from neural stem cells: Perspectives for remyelinating strategies [PDF]
, 2013 Mobilization of remyelinating cells spontaneously occurs in the adult brain. These cellular resources are specially active after demyelinating episodes in early phases of multiple sclerosis (MS).
Bernardino, Liliana +2 more
core +1 more source
Ibrain, EarlyView.Polysaccharide‐based nanoparticles offer versatile platforms for drug delivery and immune modulation in neurodegenerative diseases. This review highlights their potential in treating Alzheimer's, Parkinson's, and multiple sclerosis, focusing on targeted delivery and neuroinflammation.
Leto‐Aikaterini Tziveleka +5 more
wiley +1 more source
Metachromatic leukodystrophy and transplantation: remyelination, no cross‐correction
Annals of Clinical and Translational Neurology, 2020 In metachromatic leukodystrophy, a lysosomal storage disorder due to decreased arylsulfatase A activity, hematopoietic stem cell transplantation may stop brain demyelination and allow remyelination, thereby halting white matter degeneration.
N. Wolf +15 more
semanticscholar +1 more source
Mesenchymal Stem Cells Promote Oligodendroglial Differentiation in Hippocampal Slice Cultures [PDF]
, 2009 We have previously shown that soluble factors derived from mesenchymal stem cells (MSCs) induce oligodendrogenic fate and differentiation in adult rat neural progenitors (NPCs) in vitro.
Aigner, Ludwig +12 more
core +1 more source
Medicine Bulletin, EarlyView.ABSTRACT In multiple sclerosis (MS), demyelination is often accompanied by severe motor and cognitive disability. Remyelination is the process of regenerating new myelin sheath on impaired axons, which is typically carried out by oligodendrocyte precursor cells (OPCs).
Zixin Gao +6 more
wiley +1 more source