Results 121 to 130 of about 41,992 (300)

New Horizons for Multiple Sclerosis Therapy: 2025 and Beyond. [PDF]

Ann Neurol
The advances achieved against multiple sclerosis (MS) represent one of the great success stories of modern molecular medicine. The development of therapies with increasing selectivity and safety, guided by gains in understanding the fundamental immunology, neurobiology, genetics, and triggers of this disease, have broadened the traditional focus on ...
Sabatino JJ, Cree BAC, Hauser SL.
europepmc   +2 more sources

The adult oligodendrocyte can participate in remyelination

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Remyelination of the CNS is a critical process in restoring function and protecting nerve fibers from degeneration in multiple sclerosis and other demyelinating diseases.
I. Duncan, A. Radcliff, M. Heidari, G. Kidd, B. August, Lauren A. Wierenga   +5 more
semanticscholar   +1 more source

Targeting CXCR7/ACKR3 as a therapeutic strategy to promote remyelination in the adult central nervous system [PDF]

, 2014
Current treatment modalities for the neurodegenerative disease multiple sclerosis (MS) use disease-modifying immunosuppressive compounds but do not promote repair. Although several potential targets that may induce myelin production have been identified,
Arnett, Bajetto, Banisadr, Boldajipour, Brian P. Daniels, Calderon, Carbajal, Carbajal, Chang, Chang, Compston, Cruz-Orengo, Cruz-Orengo, Dziembowska, Franklin, Göttle, Hatse, Imitola, Jessica L. Williams, Jigisha R. Patel, Klein, Kuhlmann, Lindner, Matsuo, McCandless, McCandless, Naumann, Patel, Patel, Robyn S. Klein, Schönemeier, Steinman, Wolswijk, Xu, Zhu, Zou   +35 more
core   +2 more sources

Importance of R2 accuracy in susceptibility source separation

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose To examine the importance of R2 accuracy on independent paramagnetic and diamagnetic outputs from susceptibility source separation in the brain from two publicly available methods. Methods The effects of R2 errors, which translate into R2′$$ {\mathrm{R}}_2^{\prime } $$ errors, on output maps from χ‐separation and χ‐sepnet were examined
Tereza Beatriz Oliveira Assunção, Nashwan Naji, Jeff Snyder, Peter Seres, Gregg Blevins, Penelope Smyth, Alan H. Wilman   +6 more
wiley   +1 more source

Activation of oligodendroglial Stat3 is required for efficient remyelination

Neurobiology of Disease, 2016
Multiple sclerosis is the most prevalent demyelinating disease of the central nervous system (CNS) and is histologically characterized by perivascular demyelination as well as neurodegeneration.
Andrew J. Steelman, Yun Zhou, Hisami Koito, SunJa Kim, H. Ross Payne, Q. Richard Lu, Jianrong Li   +6 more
doaj   +1 more source

Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis

Nature Communications, 2020
Impaired oligodendrocyte (OL) differentiation and remyelination after myelin damage in multiple sclerosis is associated with neurodegeneration. The authors show that Gsta4 is expressed during adult OL differentiation and identify it as a regulator of OL ...
Karl E. Carlström, Keying Zhu, Ewoud Ewing, Inge E. Krabbendam, Robert A. Harris, Ana Mendanha Falcão, Maja Jagodic, Gonçalo Castelo-Branco, Fredrik Piehl   +8 more
doaj   +1 more source

Temporal and partial inhibition of GLI1 in neural stem cells (NSCs) results in the early maturation of NSC derived oligodendrocytes in vitro. [PDF]

, 2019
BackgroundOligodendrocytes are a type of glial cells that synthesize the myelin sheath around the axons and are critical for the nerve conduction in the CNS.
Biswas, Sangita, Chechneva, Olga, Deng, Wenbin, Mayrhofer, Florian, Namchaiw, Poommaree, Wen, Han   +5 more
core  

Phytochemical Nanoparticles for the Treatment of Neurological Disorders

Phytochemical Analysis, EarlyView.
ABSTRACT Neurological disorders impose a significant burden on the healthcare systems. The latest published data by WHO indicated that stroke was the second leading cause of death globally in 2020, with Alzheimer's disease (AD) and other dementias in the seventh position.
Touraj Ehtezazi, Satyajit D. Sarker
wiley   +1 more source

Dl-3-n-Butylphthalide Promotes Remyelination and Suppresses Inflammation by Regulating AMPK/SIRT1 and STAT3/NF-κB Signaling in Chronic Cerebral Hypoperfusion

Frontiers in Aging Neuroscience, 2020
Demyelination in vascular dementia (VD) is partly attributable to inflammation induced by chronic cerebral hypoperfusion (CCH). Remyelination contributes to the recovery of cognitive impairment by inducing the proliferation and differentiation of ...
Meixi Li, Nan Meng, Xin Guo, Xiaoli Niu, Z. Zhao, Wei Wang, Xiaohua Xie, Peiyuan Lv   +7 more
semanticscholar   +1 more source

Galectin-3-mediated glial crosstalk drives oligodendrocyte differentiation and (Re)myelination [PDF]

, 2018
Galectin-3 (Gal-3) is the only chimeric protein in the galectin family. Gal-3 structure comprises unusual tandem repeats of proline and glycine-rich short stretches bound to a carbohydrate-recognition domain (CRD).
Pasquini, Laura Andrea, Thomas, Laura
core   +1 more source