Results 161 to 170 of about 41,992 (300)

Activity and Heterogeneity of Astrocytes in Neurological Diseases: Molecular Mechanisms and Therapeutic Targets

open access: yesMedComm, Volume 6, Issue 9, September 2025.
Astrocytes display heterogeneity in various neurological disorders and behavioral neuropsychiatric disorders. Astrocytes influence the progression of neurological diseases through neuroinflammation, oxidative stress, metabolic abnormalities, intercellular interactions, and a spectrum of other pathophysiological processes.
Shijie Mao   +12 more
wiley   +1 more source

Pilot functional magnetic resonance imaging study of clemastine‐aided functional recovery on a mouse model of demyelination

open access: yesNeuroprotection
Background Multiple sclerosis (MS) is a chronic demyelinating disease characterized by autoimmune attacks on myelin sheaths. Its deleterious effects may be reversed by remyelination, a process that restores the integrity of myelin sheaths and ...
Ander Egimendia   +6 more
doaj   +1 more source

Repairing Myelin After Irradiated Pediatric Brain Tumor: A Magnetization Transfer Imaging Analysis

open access: yesPediatric Blood &Cancer, Volume 72, Issue 9, September 2025.
ABSTRACT Background While exercise training and metformin treatment have demonstrated preliminary cognitive improvements in pediatric brain tumor (PBT) survivors, the neuronal mechanisms underlying their cognitive improvements are unclear. Diffusion‐weighted metrics (e.g., fractional anisotropy [FA]) are commonly used to evaluate remyelination, but ...
Éloïse Baudou   +7 more
wiley   +1 more source

Sterol imbalances and cholesterol‐24‐hydroxylase dysregulation is linked to the underlying progression of multiple sclerosis

open access: yesBrain Pathology, Volume 35, Issue 5, September 2025.
We have sought to determine the role that cholesterol metabolism plays in disability worsening and its correlation with progressive MS by analysing patient CSF and post‐mortem tissues using cutting edge mass spectrometry approaches. Key sterol metabolites measured in the CSF link with important disability milestones at the very early stages of MS ...
Lauren Griffiths   +13 more
wiley   +1 more source

The landscape of targets and lead molecules for remyelination

open access: yesNature Chemical Biology, 2022
A. Caprariello, Drew J. Adams
semanticscholar   +1 more source

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