Heterogeneity of Pathogenesis in Multiple Sclerosis: Implications for Promotion of Remyelination [PDF]
, 2002 M. Mateo Paz Soldán, Moses Rodriguez
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Quantitative T1 is sensitive to cortical remyelination in multiple sclerosis: A postmortem MRI study
Brain Pathology, Volume 35, Issue 5, September 2025.In a post‐mortem study using multiparametric qMRI of whole fixed human brains from people with multiple sclerosis (pwMS), we found evidence that quantitative T1 (qT1) is sensitive to remyelination in the cortex. In contrast, QSM and radial diffusivity were affected by cortical pathology independently of remyelination. Our data suggest that qT1 could be
Riccardo Galbusera +14 more
wiley +1 more source
Relapsing-remitting multiple sclerosis: advances in disease-modifying therapies [PDF]
, 2015 Multiple sclerosis is a demyelinating disease affecting the central nervous system. It is the most prevalent disabling neurological condition among young adults, with onset typically between 20 and 40 years of age. Infiltrating immune cells and microglia
Kay, Kathleen Alexandra
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Remyelination of the Rat Spinal Cord by Transplantation of Identified Bone Marrow Stromal Cells [PDF]
, 2002 Yukinori Akiyama +2 more
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Engineering the Future of Restorative Clinical Peripheral Nerve Surgery
Advanced Healthcare Materials, Volume 14, Issue 20, August 8, 2025.What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell +5 more
wiley +1 more source
Defective cholesterol clearance limits remyelination in the aged central nervous system
Science, 2018 Ludovico Cantuti-Castelvetri +11 more
semanticscholar +1 more source
Remyelination of the spinal cord following intravenous delivery of bone marrow cells [PDF]
, 2002 Yukinori Akiyama +3 more
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Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine
Advanced Science, Volume 12, Issue 29, August 7, 2025.Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang +4 more
wiley +1 more source
Five decades of cuprizone, an updated model to replicate demyelinating diseases [PDF]
, 2017 : Introduction: Demyelinating diseases of the central nervous system (CNS) comprise a group of neurological disorders characterized by progressive (and eventually irreversible) loss of oligodendrocytes and myelin sheaths in the white matter tracts.
GONZALEZ PEREZ, OSCAR +7 more
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Pattern of schwann cell remyelination in a spinal cord lesion
, 1984 B.M. Harrison, John D. Pollard
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