Results 251 to 260 of about 72,813 (290)
Some of the next articles are maybe not open access.
Interactions Between Meropenem and Renal Drug Transporters
Current Drug Metabolism, 2022Background: Meropenem is a carbapenem antibiotic and is commonly used with other antibiotics for the treatment of bacterial infections. It is primarily eliminated renally by glomerular filtration and renal tubular secretion. Objective: This study aimed to evaluate the roles of renal uptake and efflux transporters in the excretion of meropenem and ...
Jing, Dong +5 more
openaire +3 more sources
Transporters and Renal Drug Elimination
Annual Review of Pharmacology and Toxicology, 2004Carrier-mediated processes, often referred to as transporters, play key roles in the reabsorption and secretion of many endogenous and xenobiotic compounds by the kidney. The renal proximal tubule is the primary site of active transport for a wide variety of substrates, including organic anions/cations, peptides, and nucleosides.
Wooin Lee, Richard B Kim
exaly +3 more sources
Renal Transporters in Drug Disposition, Drug‐Drug Interactions, and Nephrotoxicity
Current Protocols in Toxicology / Editorial Board, Mahin D Maines (editor-in-chief) [et Al ], 2012AbstractThis unit describes in detail the in vitro methods for measuring the interaction of new chemical entities (NCEs) with human renal transporters (hOAT1, hOAT2, and hOCT2) as both a substrate and inhibitor. Renal transporter substrate assays help in the identification of renal secretion mechanisms and assessment of the potential renal drug‐drug ...
Zaher A Radi
exaly +3 more sources
Renal organic anion transporters in drug–drug interactions and diseases
European Journal of Pharmaceutical Sciences, 2018 The kidney plays a vital role in maintaining systemic homeostasis. Active tubular secretion and reabsorption, which are mainly mediated by transporters, is an efficient mechanism for retaining glucose, amino acids, and other nutrients and for the clearance of endogenous waste products and xenobiotics.
Xiao-Kui Huo, Ke-Xin Liu
exaly +3 more sources
Therapeutic implications of renal anionic drug transporters
Pharmacology & Therapeutics, 2010One of most important functions of the kidney concerns the clearance of endogenous waste products, exogenously administered drugs as well as environmental exposures. In addition to glomerular filtration, active tubular secretion is an efficient mechanism for extracting compounds from the circulation and excreting them into the urinary compartment, and ...
Roos Masereeuw, Frans G M Russel
exaly +6 more sources
Mechanisms of renal anionic drug transport
European Journal of Pharmacology, 2008By utilizing filtration, active secretion and reabsorption processes, the kidney can conserve essential nutrients, and eliminate drugs and potentially toxic compounds. Active uptake of organic anions and cations across the basolateral membrane, and their extrusion into the urine across the brush border membrane mainly takes place in the renal proximal ...
El-Sheikh, A.A.K. +3 more
openaire +4 more sources
Renal Drug Transporters and Drug Interactions
Clinical Pharmacokinetics, 2017Transporters in proximal renal tubules contribute to the disposition of numerous drugs. Furthermore, the molecular mechanisms of tubular secretion have been progressively elucidated during the past decades. Organic anions tend to be secreted by the transport proteins OAT1, OAT3 and OATP4C1 on the basolateral side of tubular cells, and multidrug ...
Anton, Ivanyuk +3 more
openaire +2 more sources
Renal Drug Transport and Drug-Drug Interactions
Journal of Pharmacy Practice, 2002The kidney plays a vital role in the elimination of xenobiotics including drugs, toxins, and endogenous metabolites. Renal drug elimination involves 3 major processes: glomerular filtration, tubular secretion, and tubular reabsorption. Although glomerular filtration is a simple unidirectional diffusion process, renal tubular secretion and/or ...
Patrick T. Ronaldson, Reina Bendayan
openaire +1 more source
Molecular Aspects of Renal Anionic Drug Transport
Annual Review of Physiology, 2002▪ Abstract Multiple organic anion transporters in the proximal tubule of the kidney are involved in the secretion of drugs, toxic compounds, and their metabolites. Many of these compounds are potentially hazardous on accumulation, and it is therefore not surprising that the proximal tubule is also an important target for toxicity.
Russel, F.G.M. +2 more
openaire +5 more sources
Drug transporters and renal drug disposition in the newborn
The Journal of Maternal-Fetal & Neonatal Medicine, 2009The individual response to a drug in terms of drug efficacy and toxicity is highly variable; this represents a major problem in clinical practice. Potential causes for such variability include pathogenesis and severity of the disease being treated, drug interactions, patient age, nutritional status, renal and liver function and concomitant illness ...
De Gregori S +5 more
openaire +3 more sources