Results 271 to 280 of about 72,813 (290)
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RENAL TRANSPORT OF DRUGS: SPECIFICITY AND MOLECULAR MECHANISMS
Clinical and Experimental Pharmacology and Physiology, 1996SUMMARY1. The kidney is principally an excretory organ for drugs and their metabolites and has developed high capacity transport systems to rapidly eliminate the large quantities of foreign compounds delivered to it.2. There are specific and selective transporters for organic cations and organic anions at the contraluminal and luminal membranes of the ...
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Effects of renal failure on drug transport and metabolism
Pharmacology & Therapeutics, 2006Renal failure not only alters the renal elimination, but also the non-renal disposition of drugs that are extensively metabolized by the liver. Although reduced metabolic enzyme activity in some cases can be responsible for the reduced drug clearance, alterations in the transporter systems may also be involved in the process.
Hong, Sun +2 more
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Renal Organic Anion Transporter-Mediated Drug-Drug Interaction between Gemcabene and Quinapril
The Journal of Pharmacology and Experimental Therapeutics, 2009In humans and rats, a synergistic blood pressure reduction was observed when the fibrate gemcabene (CI-1027) was coadministered with the angiotensin-converting enzyme inhibitor quinapril. In a quinapril (3 mg/kg) pharmacokinetic rat study, there was a 40% decrease in urinary excretion and a 53% increase in plasma area under the curve from 0 to 24 h of ...
Haodan, Yuan +6 more
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Interaction of the antiviral drug telaprevir with renal and hepatic drug transporters
Biochemical Pharmacology, 2012Telaprevir is a new, direct-acting antiviral drug that has been approved for the treatment of chronic hepatitis C viral infection. First data on drug-drug interactions with co-medications such as cyclosporine, tacrolimus and atorvastatin have been reported recently.
Kunze, A. +3 more
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Drug Metabolites Potently Inhibit Renal Organic Anion Transporters, OAT1 and OAT3
Journal of Pharmaceutical Sciences, 2021Ling Zou, Pär D Matsson, Adrian Stecula
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Renal Organic Anion Transporters 1 and 3 In Vitro: Gone but Not Forgotten
International Journal of Molecular Sciences, 2023Pedro Pinto, Simone H Stahl
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Membrane transporters in drug development
Nature Reviews Drug Discovery, 2010Shiew-Mei Huang +2 more
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The Impact of Genetic Polymorphisms in Organic Cation Transporters on Renal Drug Disposition
International Journal of Molecular Sciences, 2020Zulfan Zazuli +2 more
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