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Roles of Renal Drug Transporter in Drug Disposition and Renal Toxicity
2019The kidney plays an important role in maintaining total body homeostasis and eliminating toxic xenobiotics and metabolites. Numerous drugs and their metabolites are ultimately eliminated in the urine. The reabsorption and secretion functions of the nephron are mediated by a variety of transporters located in the basolateral and luminal membranes of the
Xinning, Yang, Li, Han
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Quantitative Prediction of Renal Transporter-Mediated Clinical Drug–Drug Interactions
Molecular Pharmaceutics, 2013Kidney plays a critical role in the elimination of xenobiotics. Drug-drug interactions (DDIs) via inhibition of renal organic anion (OAT) and organic cation (OCT) transporters have been observed in the clinic. This study examined the quantitative predictability of renal transporter-mediated clinical DDIs based on basic and mechanistic models.
Bo, Feng +7 more
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Renal Drug Transport: A Review
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1996Renal drug elimination involves three major processes: glomerular filtration, tubular secretion, and tubular reabsorption. Drug filtration is a simple unidirectional diffusion process. Renal tubular secretion and reabsorption are bidirectional processes that often involve both passive diffusion and carrier‐mediated membrane processes.
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Drug Interactions Involving Renal Transport Mechanisms: An Overview
DICP, 1989The renal anatomy, physiology, and cellular mechanisms involved in tubular transport of organic acids (anions) and bases (cations) are reviewed. Drugs that are renally secreted are prone to significant and complex drug-drug interactions, and knowledge of the underlying mechanisms is important.
T, Kosoglou, P H, Vlasses
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Renal tubular transporters and antiviral drugs: an update
AIDS, 2005Systemic disposition of antiviral drugs partly depends on renal handling of these compounds. There are some known, functionally characterized anionic and cationic transporters with varying substrate specificities for those drugs: human organic anion transporter (OAT) family (hOAT1-3) and human organic cation transporter (OCT) family (hOCT1-3), which ...
Hassane, Izzedine +2 more
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Renal transport mechanisms for xenobiotics: chemicals and drugs
The Clinical Investigator, 1993Using the stopped flow tubular lumen or peritubular capillary microperfusion method, the apparent Ki values of a large number of organic anions and cations against the respective transport systems were evaluated. Thereby the luminal transport system for monocarboxylates (lactate), the contraluminal and luminal transport systems for dicarboxylates ...
Ullrich, K., Rumrich, G.
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EVALUATION OF DRUG-DRUG INTERACTION IN THE HEPATOBILIARY AND RENAL TRANSPORT OF DRUGS
Annual Review of Pharmacology and Toxicology, 2005▪ Abstract Recent studies have revealed the import role played by transporters in the renal and hepatobiliary excretion of many drugs. These transporters exhibit a broad substrate specificity with a degree of overlap, suggesting the possibility of transporter-mediated drug-drug interactions with other substrates.
Yoshihisa, Shitara +2 more
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1981
The kidneys are the most important organs for elimination of drugs and their metabolites. Several pathways have been described as being involved in this process. However, for many drugs the exact route of renal excretion is unknown. Detailed analyses at the level of individual tubules are rather scarce, mainly due to the lack of specific analytic ...
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The kidneys are the most important organs for elimination of drugs and their metabolites. Several pathways have been described as being involved in this process. However, for many drugs the exact route of renal excretion is unknown. Detailed analyses at the level of individual tubules are rather scarce, mainly due to the lack of specific analytic ...
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Renal Excretion of Drugs: Tubular Transport and Metabolism
Annual Review of Pharmacology, 1972The regulatory control of renal excretion of drugs and autopharmaco logical agents results from either renal tubular reabsorption of filtered so lutes or the excretion of solutes into the lumen from peritubular blood. These tubular processes may be active transport processes or passive non ionic diffusion of lipid soluble substrates.
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Effects of Chronic Renal Failure on Liver Drug Transporters
Drug Metabolism and Disposition, 2008Chronic renal failure (CRF) is associated with a decrease in liver drug metabolism, particularly mediated by the cytochrome P450. CRF also impedes intestinal drug transporters [mainly P-glycoprotein (P-gp) and multidrug resistance protein (MRP)]. However, very few studies have evaluated the effects of CRF on liver drug transport.
Judith, Naud +5 more
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