Results 101 to 110 of about 80,731 (303)

Mapping the Global Clinical Landscape of Pharmacological Therapies for Heart Failure With Preserved Ejection Fraction: An Analysis Based on ClinicalTrials.gov (2003–2025)

iMetaMed, EarlyView.
This study analyzed 236 heart failure with preserved ejection fraction (HFpEF) pharmacological trials registered on ClinicalTrials.gov from 2003 to 2025, revealing a post‐2016 surge (76.3%), U.S. dominance (58.5%), and prominence of SGLT2 inhibitors/novel therapies (each 13.1%).
Yucheng Hou, Jingwei Zhao, Yuqian Tang, Tan Liu, Zhiao Zhang, Ziheng Wang, Han Shen   +6 more
wiley   +1 more source

Neurohormonal Activation and Left Atrium Remodeling in Mitral Stenosis

Majalah Kardiologi Indonesia, 2017
Mitral stenosis is closely related with the hemodynamic consequences of obstructed mitral leaflet. Definitive therapy in mitral stenosis is mechanical intervention. Late presentation of mitral stenosis patients to medical facilities due to limited health
Vidya Gilang Rejeki, Bambang Budi Siswanto, Nani Hersunarti   +2 more
doaj   +1 more source

From cytokine storm to renal scarring in diabetic kidney disease: Biomarkers, risk stratification, and precision therapeutics

Precision Medical Sciences, EarlyView.
Hyperglycemia‐driven cytokine activation initiates a sustained inflammatory cascade in diabetic kidney disease, promoting cellular injury and fibrogenic signaling. Integrating cytokine‐based biomarkers with risk stratification enables precision therapeutics that target inflammation and fibrosis, ultimately aiming to halt progression from early renal ...
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

Long-term exercise attenuates blood pressure responsiveness and modulates kidney angiotensin II signalling and urinary sodium excretion in SHR

, 2015
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Observations have been made regarding the effects of long ...
Borges, Rafael, Gontijo, José A R, Gontijo, JAR, Cambiucci, Elizabeth C, Borges, R, Mesquita, FF, de Lima, IP, Cambiucci, EC, de Lima, Ize P, Mesquita, Flávia F, Ciampone, S, Ciampone, Silmara   +11 more
core   +1 more source

Postnatal Changes of Renin and Aldosterone in Term and Preterm Infants from Birth to Day 5

Biomedicines
Background/Objectives: The renin–angiotensin–aldosterone system (RAAS) is pivotal for neonatal circulation and renal adaptation; however, postnatal changes in serum renin and aldosterone immediately after birth remain unclear.
Yukihito Imagawa, Yu Masuda, Yuki Nakata, Kentaro Fujitani, Aine Takahashi, Keisuke Shirai, Takumi Kido, Mariko Ashina, Kenji Tanimura, Kandai Nozu, Kazumichi Fujioka   +10 more
doaj   +1 more source

Hepatic Mitochondrial Renin-Angiotensin Systems

, 2015
Introduction: The circulating renin-angiotensin system (RAS) was originally described as a key endocrine regulator of intravascular homeostasis; however, the existence of a local (tissue) RAS has become increasingly reported in a variety of tissues ...
Skipworth, JRA
core  

Hormone Replacement Therapy Uptake and Discontinuation Trends From 1996‐2023: An Observational Study of the Welsh Population

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To analyse prescribing trends for oral and transdermal hormone replacement therapy (HRT) in Wales from 1996 to 2023, including predictors of discontinuation within one year of initiation. Design Observational study using the Secure Anonymised Information Linkage (SAIL) databank.
Robin Andrews, Arron Lacey, Kate Bache, Emma J. Kidd   +3 more
wiley   +1 more source

Changes in the renin-angiotensin-aldosterone system in female mice with cardiac-specific null mutation of Prdm16.

, 2022
(A) Aldosterone levels, (B) renin activity, and (C) aldosterone-to-renin activity ratio (ARR) in plasma. (D) mRNA levels in liver, lung, and kidney for components of the renin-angiotensin system.
Ji Eun Lim (10829187), Tae Woong Ha (13132217), Ji-One Kang (844616), Bermseok Oh (39719), Hae-Un Jung (10829181)   +4 more
core   +1 more source

Systemic medications associate with surgically treated cataract among adults over 50 years in Finland

Acta Ophthalmologica, EarlyView.
Abstract Purpose To identify associations between systemic drugs and cataract surgery in Finland. Methods A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs.
Antti Riikonen, Jari Haukka, Tuomas Lilius, Sirpa Loukovaara   +3 more
wiley   +1 more source

Associations of genetic polymorphisms in the renin-angiotensin system with central aortic and ambulatory blood pressure in type 2 diabetic patients

, 2014
Patients with type 2 diabetes (T2D) are at high risk of developing hypertension and related cardiovascular disease. The renin-angiotensin system (RAS) plays a central role in regulation of blood pressure (BP).
Länne, Toste,, Östgren, Carl Johan,, Ljungberg, Liza U.,, Nyström, Fredrik H.,, Nyström, Fredrik H,, Johan Östgren, Carl,, Ljungberg, Liza,   +6 more
core   +1 more source