Fibroblast growth factor 23 is induced by an activated renin–angiotensin–aldosterone system in cardiac myocytes and promotes the pro-fibrotic crosstalk between cardiac myocytes and fibroblasts [PDF]
, 2018 Maren Leifheit‐Nestler +7 more
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Diabetes, Obesity and Metabolism, EarlyView.Abstract Aims Sotagliflozin, an inhibitor of sodium‐glucose co‐transporter (SGLT)‐1 and 2, reduces albuminuria, slows GFR decline, and may have diuretic and osmoregulatory effects. The effect of sotagliflozin added to insulin was assessed on markers of neurohormone activation and volume homeostasis in patients with type 1 diabetes (T1D).
Massimo Nardone +6 more
wiley +1 more source
The behavior of renal-regulating hormones during hypogravic stress [PDF]
The regulation of fluid and electrolyte behavior during space flight is believed to be under control, in large part, of a group of hormones which have their major effects on renal excretion. The hormones studied include renin-angitensin, aldosterone, and
Leonard, J. I.
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Dipeptidyl peptidase 3, a marker of the antagonist pathway of the renin–angiotensin–aldosterone system in patients with heart failure [PDF]
, 2021 Eva M. Boorsma +10 more
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The FEBS Journal, EarlyView.Angiotensin I‐converting enzyme (ACE) contains two catalytic domains (nACE and cACE) and is a key therapeutic target for hypertension and cardiovascular disease. Current ACE inhibitors (ACEi) nonselectively inhibit both domains, causing adverse effects. Selective inhibition requires an understanding of domain‐specific binding.
Kyle S. Gregory +3 more
wiley +1 more source
Gastrointestinal endogenous proteins as a source of bioactive peptides : Doctor of Philosophy in Nutritional Sciences at Riddet Institute, Massey University, Palmerston North, New Zealand [PDF]
, 2016 Gastrointestinal endogenous proteins (GEP) were investigated as a source of bioactive peptides. In silico and in vitro methods were used singly or in combination to study GEP-derived peptides after simulated digestion.
Acharya, Prasannalakshmi
core
Laborbeurteilung des Renin-Angiotensin-Aldosteron-Systems
, 2021 The renin-angiotensin-aldosterone-system or RAAS is one of the most important, endogenous systems for maintaining homeostasis of electrolytes, body fluid level and blood pressure. Many diseases stemming from dysregulation in the RAAS become symptomatic by derailment of electrolytes or blood pressure.
openaire +2 more sources
Association between renin–angiotensin–aldosterone system-related genes and blood pressure in a Korean population [PDF]
, 2011 Se-Bin Song +9 more
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Hepatology Research, EarlyView.Sacubitril/Valsartan (Sac/Val) alleviates fibrosis and inflammation in metabolic dysfunction‐associated steatohepatitis (MASH). Its anti‐fibrotic effect is linked to the suppression of Integrin alpha 8 (Itga8), a protein crucial for hepatic stellate cell (HSC) activation and collagen production.
Hayato Kawamura +11 more
wiley +1 more source
International Journal of Dermatology, EarlyView.ABSTRACT Background Prurigo nodularis patients face a significant burden of comorbidities, necessitating a comprehensive approach to care. We aimed to explore the association between prurigo nodularis, its comorbid conditions, and healthcare usage patterns.
Yuliya Valdman‐Grinshpoun +4 more
wiley +1 more source