Results 11 to 20 of about 141,530 (342)

The Impact of the Renin-Angiotensin-Aldosterone System on Inflammation, Coagulation, and Atherothrombotic Complications, and to Aggravated COVID-19

Frontiers in Pharmacology, 2021
Atherosclerosis is considered a disease caused by a chronic inflammation, associated with endothelial dysfunction, and several mediators of inflammation are up-regulated in subjects with atherosclerotic disease.
M. Ekholm, T. Kahan
doaj   +2 more sources

The renin-angiotensin-aldosterone system and its suppression [PDF]

Journal of Veterinary Internal Medicine, 2019
Chronic activation of the renin‐angiotensin‐aldosterone system (RAAS) promotes and perpetuates the syndromes of congestive heart failure, systemic hypertension, and chronic kidney disease.
Marisa K. Ames, Clarke E. Atkins, Bertram Pitt   +2 more
openalex   +2 more sources

Role and Mechanism of the Renin-Angiotensin-Aldosterone System in the Onset and Development of Cardiorenal Syndrome

Journal of the Renin-Angiotensin-Aldosterone System, 2022
Cardiorenal syndrome (CRS), a clinical syndrome involving multiple pathological mechanisms, exhibits high morbidity and mortality. According to the primary activity of the disease, CRS can be divided into cardiorenal syndrome (type I and type II), renal ...
Kexin Ma, Weifang Gao, Huazhou Xu, Wenjie Liang, Guoping Ma   +4 more
semanticscholar   +1 more source

COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system

Nature Communications, 2021
SARS-CoV-2 uses ACE2, an inhibitor of the Renin-Angiotensin-Aldosterone System (RAAS), for cellular entry. Studies indicate that RAAS imbalance worsens the prognosis in COVID-19.
S. Rysz, Jonathan Al-Saadi, A. Sjöström, M. Farm, Francesca Campoccia Jalde, M. Plattén, Helen Eriksson, Margareta Klein, R. Vargas-Paris, S. Nyrén, G. Abdula, R. Ouellette, T. Granberg, M. Jonsson Fagerlund, J. Lundberg   +14 more
semanticscholar   +1 more source

Effects of SGLT2 Inhibitors and GLP-1 Receptor Agonists on Renin-Angiotensin-Aldosterone System

Frontiers in Endocrinology, 2021
Sodium-glucose cotransporters inhibitors (SGLT2-i) and GLP-1 receptor agonists (GLP1-RA) are glucose-lowering drugs that are proved to reduce the cardiovascular (CV) risk in type 2 diabetes mellitus (T2DM).
S. Puglisi, A. Rossini, Roberta Poli, F. Dughera, A. Pia, M. Terzolo, G. Reimondo   +6 more
semanticscholar   +1 more source

Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19

New England Journal of Medicine, 2020
RAAS Inhibitors in Patients with Covid-19 The effects of renin–angiotensin–aldosterone system blockers on angiotensin-converting enzyme 2 levels and activity in humans are uncertain.
M. Vaduganathan, O. Vardeny, T. Michel, J. McMurray, M. Pfeffer, S. Solomon   +5 more
semanticscholar   +1 more source

Renin–Angiotensin–Aldosterone System Inhibitors and Risk of Covid-19

New England Journal of Medicine, 2020
Background There is concern about the potential of an increased risk related to medications that act on the renin–angiotensin–aldosterone system in patients exposed to coronavirus disease 2019 (Covid-19), because the viral receptor is angiotensin ...
H. Reynolds, S. Adhikari, C. Pulgarin, A. Troxel, Eduardo Iturrate, Stephen B. Johnson, A. Hausvater, J. Newman, J. Berger, S. Bangalore, S. Katz, G. Fishman, Dennis Kunichoff, Yu Chen, G. Ogedegbe, J. Hochman   +15 more
semanticscholar   +1 more source

Targeting the Renin–Angiotensin–Aldosterone System to Prevent Hypertension and Kidney Disease of Developmental Origins

International Journal of Molecular Sciences, 2021
The renin-angiotensin-aldosterone system (RAAS) is implicated in hypertension and kidney disease. The developing kidney can be programmed by various early-life insults by so-called renal programming, resulting in hypertension and kidney disease in ...
Chien-Ning Hsu, Y. Tain
semanticscholar   +1 more source

Renin–Angiotensin–Aldosterone System Blockers and the Risk of Covid-19

New England Journal of Medicine, 2020
Background A potential association between the use of angiotensin-receptor blockers (ARBs) and angiotensin-converting–enzyme (ACE) inhibitors and the risk of coronavirus disease 2019 (Covid-19) has not been well studied.
G. Mancia, F. Rea, M. Ludergnani, G. Apolone, G. Corrao   +4 more
semanticscholar   +1 more source

Influence and implications of the renin–angiotensin–aldosterone system in obstructive sleep apnea: An updated systematic review and meta‐analysis

Journal of Sleep Research, 2022
Obstructive sleep apnea is a chronic, sleep‐related breathing disorder, which is an independent risk factor for cardiovascular disease. The renin–angiotensin–aldosterone system regulates salt and water homeostasis, blood pressure, and cardiovascular ...
H. H. Loh, Q. Lim, C. Chai, S. Goh, L. Lim, A. Yee, N. Sukor   +6 more
semanticscholar   +1 more source