Results 261 to 270 of about 80,731 (303)
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Renin-angiotensin-aldosterone system
European Journal of Clinical Pharmacology, 1980There is increased activity of the renin, angiotensin, aldosterone (RAA) system in infancy and childhood. An inverse relationship between plasma renin, aldosterone and age has been demonstrated. In childhood hypertension due to renovascular disease or pyelonephritic scarring peripheral plasma renin is increased.
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The Renin-Angiotensin-Aldosterone System
2019The renin—angiotensin—aldosterone system (RAAS) is one of the oldest hormonal systems—regardless of whether ‘old’ is defined as phylogenetically old, or in the sense of being discovered a long time ago. Originally, the RAAS has been described as a circulating endocrine system, with angiotensinogen being released by the liver, and renin secreted from ...
Steckelings, Ulrike Muscha +1 more
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Imaging the renin-angiotensin-aldosterone system in the heart
Current Heart Failure Reports, 2005The influence of the renin-angiotensin system (RAS) is recognized in cardiac and vascular injury. An extrinsic RAS has been known for decades, and an equally important intrinsic RAS has been discovered recently. The latter leads to pathologic tissue alterations in the absence of systemic stimuli and may be the main source of local tissue effects of RAS.
Jamshid, Shirani +4 more
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Myocardial Fibrosis and the Renin-Angiotensin-Aldosterone System
Journal of Cardiovascular Pharmacology, 1992In both men and women left ventricular hypertrophy (LVH) is the major risk factor associated with the appearance of diastolic and/or systolic myocardial failure. It is not the growth of cardiac myocytes, however, that is responsible for an abnormal structural remodeling of the hypertrophied myocardium in pathologic LVH, but instead, nonmyocyte cells ...
K T, Weber, C G, Brilla
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Renin-Angiotensin-Aldosterone System in Hypertrophic Cardiomyopathy
Kardiologiia, 2014Keeping in mind an important role of renin-angiotensin aldosterone system (RAS) in developing of cardiac remodeling and fibrosis, genetic polymorphisms coding its components could have influence with clinical variants of the course. Biomarkers could appear predictors of adverse.
M V, Kozhevnikova +4 more
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Perspectives on the renin-angiotensin-aldosterone system in hypertension
Metabolism, 1974Abstract In the syndrome of hyperaldosteronism, the abnormal electrolyte metabolism, secondary to mineralocorticoid excess, seems to play a predominant pathogenetic role in causing elevation of the blood pressure, since the renin-angiotensin system is depressed and unresponsive.
A H, Vagnucci, A P, Shapiro
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Ventricular Remodeling and the Renin Angiotensin Aldosterone System
Congestive Heart Failure, 2000Ventricular remodeling in patients with left ventricular systolic dysfunction is an indolent process that is associated with a poor prognosis. Clinical and experimental data support the central role played by the renin‐angiotensin‐aldosterone system in the pathophysiology of remodeling.
R D, Patten, M A, Konstam
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Pathologic hypofunction of the renin-angiotensin-aldosterone system
Postgraduate Medicine, 1976The literature now contains reports of many cases of aldosterone deficiency. Usually, the presenting features are persistent hyperkalemia and tendencies to serious urinary sodium loss and hypotension. A classification of defects leading to pathologic hypofunction of the renin-angiotensin-aldosterone system (RAAS hypofunction) is presented, with ...
J N, Priest, M, Ahmed, F Q, Nuttall
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Drugs targeting the renin–angiotensin–aldosterone system
Nature Reviews Drug Discovery, 2002Effective antihypertensive therapy has made a major contribution to the reductions in the morbidity and mortality of cardiovascular disease that have been achieved since the 1960s. However, blood-pressure control with conventional drugs has not succeeded in reducing cardiovascular disease risks to levels seen in normotensive persons. Drugs that inhibit
Mohammad Amin, Zaman +2 more
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Therapeutic inhibition of the renin angiotensin aldosterone system
Expert Opinion on Therapeutic Patents, 2009Inhibitors of the renin angiotensin aldosterone system (RAAS) represent some of the most widely prescribed, successful and well-tolerated therapeutics of recent times and are of proven worth in the management/prevention of cardiovascular disease and diabetic nephropathy. However, as knowledge has grown about the RAAS and its manifold alternate pathways,
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