Results 191 to 200 of about 18,284,607 (258)

Chronic estrogen supplementation in the aging castrated male rat is not associated with renal injury or activation of the renin angiotensin system. [PDF]

J Appl Physiol (1985)
Mallette JH, Crudup BF, Oudomrath Speyrer A, Nabors HM, Willis AT, Rawls AZ, Alexander BT.   +6 more
europepmc   +1 more source

TREM2+ macrophages accumulate in childhood IgA nephropathy and soluble TREM2 represents a reliable non‐invasive biomarker

Experimental Physiology, EarlyView.
Abstract IgA nephropathy (IgAN) is a common type of primary glomerulonephritis in children. The pathogenesis of childhood IgAN remains unclear, and there is a lack of effective non‐invasive biomarkers for this disease. Single‐cell RNA sequencing was performed in children with IgAN to delineate cellular and molecular compositions, and subcluster ...
Ling Yu, Xuan Gang, Jingjing Wang, Guoping Huang, Qiuyu Li, Weizhong Gu, Haidong Fu, Jianhua Mao   +7 more
wiley   +1 more source

Risks of dementia and stroke in patients with hypertension using telmisartan or other renin‑angiotensin system inhibitors. [PDF]

Alzheimers Dement
Liu CH, Tsai ML, Yang NI, Chang TY, Chen TH, Wei YC.   +5 more
europepmc   +1 more source

Sodium–glucose cotransporter 2 inhibitors for hypertension in cardiovascular–kidney–metabolic syndrome

Experimental Physiology, EarlyView.
Abstract The antihypertensive mechanism of sodium–glucose cotransporter 2 (SGLT2) inhibitors has been traditionally attributed to osmotic diuresis. However, emerging evidence reveals multifaceted mechanisms beyond diuresis, including regulation of the renin–angiotensin–aldosterone system, sympathetic nervous system suppression, ion homeostasis ...
Chunxiang Xu, Xingyu Qiu, Nan Xu, Gensheng Zhang, Enyin Lai, Liang Zhao   +5 more
wiley   +1 more source

Neuroprotective effects of telmisartan in a harmaline-induced model of essential tremor: modulation of the renin-angiotensin system and inflammatory pathways. [PDF]

Front Pharmacol
Farrag SM, Emam AM, Kamel AS, Saad MA, Kortam MA, Sayed NH, Fathy N.   +6 more
europepmc   +1 more source

Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials

Experimental Physiology, EarlyView.
Abstract Ageing impairs renal resilience with an elevated risk of frequent and harmful acute kidney injury (AKI) that causes substantial morbidity and mortality among hospitalized patients. Since different damaging stimuli at the molecular, cellular and functional level contribute to this loss in kidney function, AKI's pathophysiology is heterogeneous ...
Felix C. Koehler, Pedro Rojas‐Morales, Roman‐Ulrich Müller   +2 more
wiley   +1 more source

Beyond blood pressure: the renin-angiotensin system as an innovative driver and therapeutic target in pathological scarring. [PDF]

Front Pharmacol
Shi BH, Zhang XG, Fang QQ, Xu K, Chen XL, Tan WQ, Wang SJ.   +6 more
europepmc   +1 more source

Contributions of vascular ageing to late‐onset Alzheimer's disease

Experimental Physiology, EarlyView.
Abstract Late‐onset Alzheimer's disease (LOAD) is an age‐related disease that is strongly associated with vascular risk factors and cerebrovascular impairments. As such, changes in the vasculature with advancing age likely contribute to LOAD, but the mechanisms underlying these contributions remain incompletely understood.
Skylyn J. Ferguson, Young Deanna Choi, Ashley E. Walker   +2 more
wiley   +1 more source

Kidney Effectiveness and Safety of Adding Spironolactone in Patients With Type 2 Diabetes Receiving Renin-Angiotensin System Inhibitors Therapy. [PDF]

Clin Transl Sci
Lin WR, Huang TS, Chang HH, Chao JY, Chang YH, Yang CY, Ou HT, Lin WH.   +7 more
europepmc   +1 more source

Cerebral blood flow in conscious rats and implications for therapeutic interventions

Experimental Physiology, EarlyView.
Abstract Cerebral blood flow (CBF) often becomes compromised in patients suffering from cardiovascular diseases, increasing the risk of neurodegenerative disease and vascular dementia. There is an urgent need for treatments to address cardiovascular risk without compromising brain perfusion, yet the impact of many existing treatments on CBF are not ...
Tonja W. Emans, Courtney R. Brighouse, Jack T. Sloan, Fiona D. McBryde   +3 more
wiley   +1 more source