Genomic Evidence on Antihypertensive Drug Targets and Oral Disease Outcomes
Key Findings Drug‐target Mendelian randomization showed little evidence that genetically proxied on‐target pharmacological actions of most antihypertensive drug classes were associated with chronic periodontitis or dental caries. The diazoxide–periodontitis association requires cautious interpretation, given possible residual pleiotropy at KCNJ11 and ...
Aiswarya Puzhakkara Chennas +7 more
wiley +1 more source
Endocrine society 2025 diagnostic criteria increase primary aldosteronism detection in hypertensive patients: a comparative study with 2016 guidelines. [PDF]
Cherdo C +5 more
europepmc +1 more source
Association between obstructive sleep apnea (OSA) and COVID‐19 severity
Summary Obstructive sleep apnea and sleep‐related hypoxia have been associated with higher rates of hospitalization and mortality among patients with Coronavirus disease 2019 (COVID‐19). We further explored the association between obstructive sleep apnea, COVID‐19 severity and related mortality.
Oria Nassi‐Liberman +4 more
wiley +1 more source
It's About Time: Potassium Risk With Combination Guideline-Directed Medical Therapy. [PDF]
Sinclair MR, Edmonston D.
europepmc +1 more source
ABSTRACT Aims The oral microbiome is at the frontline for environmental exposure and plays an important role in human metabolism. This study explores the relationship between PM2.5 exposure, the oral microbiome, and metabolic biomarkers including ghrelin, resistin, and insulin.
Jiajun Luo +5 more
wiley +1 more source
Tacrolimus Induced Hypertension and Vascular Remodeling Includes Mechanisms of Cellular Senescence-The Protective Effect of Valsartan. [PDF]
Fei L +23 more
europepmc +1 more source
ABSTRACT Objectives To identify molecular mechanisms distinguishing the erosive subtype of oral lichen planus (EOLP) from the non‐erosive subtype (NEOLP) through transcriptomic analysis. Methods We analysed bulk RNA‐seq data from 30 buccal mucosa samples (13 EOLP, 17 NEOLP) using differential expression, Gene Set Enrichment Analysis (GSEA ...
Kisung Sheen +5 more
wiley +1 more source
Relationship between blood pressure level and activity of renin-aldosterone axis in patients with essential hypertension-a retrospective study. [PDF]
Li P +5 more
europepmc +1 more source
Abstract Blood flow restriction (BFR) has been identified as a potential countermeasure to mitigate physiological deconditioning during spaceflight. Guidelines recommend that tourniquet pressure be prescribed relative to limb occlusion pressure (LOP); however, it is unclear whether body tilting or reduced gravity analogues influence LOP.
Patrick Swain, Nick Caplan, Luke Hughes
wiley +1 more source
Case Report: A case of pediatric reninoma and literatures review. [PDF]
Zhao W +6 more
europepmc +1 more source

