Results 151 to 160 of about 168,039 (206)
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Is Angiotensinogen a Renin Inhibitor and Not the Substrate for Renin?
Journal of Hypertension, 1986The cleavage of the angiotensinogen molecule by renin is slow. The rate constant for cleavage of the enzyme-substrate complex, Kcat (turnover number) is lower than usual for enzymes (0.6/s for the homologous human renin reactions and 0.15/s for the homologous mouse renin reaction).
K, Poulsen, J, Jacobsen
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Renin, Renin Inhibition and Antihypertensive Therapy
Clinical and Experimental Hypertension. Part A: Theory and Practice, 1983Research over the last 25 years established the renin-angiotensin-aldosterone system's important role in electrolyte and blood pressure homeostasis as well as in the pathophysiology of hypertension for which renin suppressive drugs, angiotensin antagonists and converting enzyme inhibitors provided selective pharmacological tools.
F. R. Bühler +1 more
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The Journal of Clinical Endocrinology & Metabolism, 1977
Renin activity, concentration, substrate and reactivity were determined in normal subjects as well as in hypertensive subjects with suppressed and normal plasma renin activity. Renin substrate measurements were similar in all groups. Renin reactivity, a measure of circulating modifiers of the renin reaction, was significantly increased in both ...
W J, McDonald, E L, Cohen, J W, Conn
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Renin activity, concentration, substrate and reactivity were determined in normal subjects as well as in hypertensive subjects with suppressed and normal plasma renin activity. Renin substrate measurements were similar in all groups. Renin reactivity, a measure of circulating modifiers of the renin reaction, was significantly increased in both ...
W J, McDonald, E L, Cohen, J W, Conn
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Biochemical Society Transactions, 1984
Biochemical features of renin have been studied. Determination of the amino acid sequence and catalytically essential groups in the active sites of mouse submandibular gland revealed the similarity of renin with acid proteases. Yet stringent substrate specificity, neutral pH optimum of its enzyme activity and the unique structure of the activation ...
T, Inagami +3 more
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Biochemical features of renin have been studied. Determination of the amino acid sequence and catalytically essential groups in the active sites of mouse submandibular gland revealed the similarity of renin with acid proteases. Yet stringent substrate specificity, neutral pH optimum of its enzyme activity and the unique structure of the activation ...
T, Inagami +3 more
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Renin, Prorenin, and the (Pro)Renin Receptor
2009The discovery of a receptor for renin and for its inactive precursor prorenin, and the introduction of renin inhibitors in therapeutic, has renewed the interest for the physiology of the renin angiotensin system (RAS) and has brought prorenin back in the spotlight.
Genevieve Nguyen, Aurelie Contrepas
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Ergebnisse der Physiologie Biologischen Chemie und Experimentellen Pharmakologie, 1959
The reviewer of this subject can approach his task in two ways; he can attempt to be exhaustive and include all the references to all the literature on the subject, or he can be selective and consider only that which has thrown new light in recent years. I propose to take the latter course.
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The reviewer of this subject can approach his task in two ways; he can attempt to be exhaustive and include all the references to all the literature on the subject, or he can be selective and consider only that which has thrown new light in recent years. I propose to take the latter course.
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Pharmaceutical Research, 1987
Since the early 1980s, an intensive effort has been focused on the development of orally effective and long-acting inhibitors of renin. During this time, in vitro potency has increased greatly, with several transition-state inhibitor designs yielding inhibitors with subnanomolar IC50 values.
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Since the early 1980s, an intensive effort has been focused on the development of orally effective and long-acting inhibitors of renin. During this time, in vitro potency has increased greatly, with several transition-state inhibitor designs yielding inhibitors with subnanomolar IC50 values.
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Renin, (pro)renin and receptor: an update
Clinical Science, 2010PRR [(pro)renin receptor] was named after its biological characteristics, namely the binding of renin and of its inactive precursor prorenin, that triggers intracellular signalling involving ERK (extracellular-signal-regulated kinase) 1/2. However the gene encoding for PRR is named ATP6ap2 (ATPase 6 accessory protein 2) because PRR was initially found ...
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1989
In the last decade renin research progressed rapidly. This was due to the development of protein and peptide chemistry, modern immunology and molecular biology.
T, Kokubu +3 more
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In the last decade renin research progressed rapidly. This was due to the development of protein and peptide chemistry, modern immunology and molecular biology.
T, Kokubu +3 more
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American Journal of Obstetrics and Gynecology, 1988
I should state at the outset that this article is not about hypertension, although that subject is inevitably part of any review of the renin-angiotensin system. Nevertheless, a hormone system that plays a major role in the regulation of sodium excretion and produces a very potent vasoconstrictor with a majorfunctional base in the genital tract must be
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I should state at the outset that this article is not about hypertension, although that subject is inevitably part of any review of the renin-angiotensin system. Nevertheless, a hormone system that plays a major role in the regulation of sodium excretion and produces a very potent vasoconstrictor with a majorfunctional base in the genital tract must be
openaire +2 more sources