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Page Kidney: An Unusual Cause of Acute Onset Hypertension-A Case Report. [PDF]

Reports (MDPI)
Koutsoulas K, Karagiannis E, Kouroupis D, Vlachos I, Papadopoulos S, Pateinakis P, Pyrpasopoulou A, Vouros I, Goulis I.   +8 more
europepmc   +1 more source

Renin Release

Physiology, 2007
The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in salt, volume, and blood pressure homeostasis of the body. Renin is mainly produced and released into circulation by the so-called juxtaglomerular epithelioid cells, located in the walls of renal afferent arterioles at the ...
Schweda, Frank, Friis, Ulla, Wagner, Charlotte, Skøtt, Ole, Kurtz, Armin   +4 more
openaire   +3 more sources

Renin Tachyphylaxis and ‘Renin Hypertension’ in the Rabbit

American Journal of Physiology-Legacy Content, 1956
A ‘renin hypertension’ was produced by means of a constant intravenous infusion of a carefully quantitated renin solution. Renin injections were then superimposed to the point of tachyphylaxis. In all cases when tachyphylaxis was established, the blood pressure gradually returned to preinfusion levels.
S, SCHAPIRO, D B, GORDON, D R, DRURY
openaire   +3 more sources

The Renin Prosequence Enhances Constitutive Secretion of Renin and Optimizes Renin Activity

Current Neurovascular Research, 2011
Renin is cleaved from its precursor prorenin into mature renin. We investigated the impact of the renin proregion on the generation and secretion of enzymatically active renin. We compared the effects of the following sequences of human prorenin with those of wild type prorenin[1-383]: prosequence [1-43], hinge sequence [1-62], Des[1-43]prorenin ...
Brakch, N., Allemandou, F., Keller, I., Nussberger, J.   +3 more
openaire   +5 more sources

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[From the renin gene to renin inhibitors].

Annales d'endocrinologie, 1986
The only known action of renin is the hydrolysis of angiotensinogen into angiotensin I. Renin is synthesized as an inactive precursor, preprorenin. The processing of prorenin into active renin occurs after the clivage of a profragment, just after a dibasic pair of amino-acids.
P, Corvol, J, Ménard
openaire   +3 more sources

The Nature of Renin Precursor and Inactive Renin

Clinical and Experimental Hypertension. Part A: Theory and Practice, 1982
The biosynthesis of renin in the mouse submaxillary gland was defined using both cell-free translation and pulse-labelling methods. Renin is synthesized as a preproform and cleaved by microsomes to the proform. Prorenin (MW = 46 kilodaltons, pI 6.35) is processed intracellulary into an intermediate form (MW = 41 kilodaltons). The latter is converted by
V J, Dzau, A, Tanaka, R E, Pratt
openaire   +2 more sources

Inactive Renin — A Renin Proenzyme?

1977
Human plasma contains an inactive form of renin with a m.w. of 55,000, as against around 40,000 for active human renin. After acidification to pH 3.0 or incubation with trypsin, the inactive renin becomes more active and the molecular weight falls to that of active renin.
B J, Leckie, A, McConnell, J, Jordan
openaire   +2 more sources