Results 121 to 130 of about 39,387 (167)
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American Journal of Obstetrics and Gynecology, 1988
I should state at the outset that this article is not about hypertension, although that subject is inevitably part of any review of the renin-angiotensin system. Nevertheless, a hormone system that plays a major role in the regulation of sodium excretion and produces a very potent vasoconstrictor with a majorfunctional base in the genital tract must be
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I should state at the outset that this article is not about hypertension, although that subject is inevitably part of any review of the renin-angiotensin system. Nevertheless, a hormone system that plays a major role in the regulation of sodium excretion and produces a very potent vasoconstrictor with a majorfunctional base in the genital tract must be
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Current Opinion in Nephrology & Hypertension, 2006
Initial attempts to inhibit renin in humans have faced numerous difficulties. Molecular modeling and X-ray crystallography of the active site of renin have led to the development of new orally active renin inhibitors, such as aliskiren. Recent preclinical and clinical data suggest that this drug may be of value for treating patients with cardiovascular
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Initial attempts to inhibit renin in humans have faced numerous difficulties. Molecular modeling and X-ray crystallography of the active site of renin have led to the development of new orally active renin inhibitors, such as aliskiren. Recent preclinical and clinical data suggest that this drug may be of value for treating patients with cardiovascular
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Nephron, 2008
The factors involved in renin release have been extensively evaluated. The primary determinants are the transmural pressure at the afferent arteriole, sodium delivery to the macula densa, and the activity of the adrenergic nervous system. Other possible factors include circulating catecholamines, the serum and cerebrospinal fluid sodium concentration ...
A M, Chonko, J H, Stein, T F, Ferris
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The factors involved in renin release have been extensively evaluated. The primary determinants are the transmural pressure at the afferent arteriole, sodium delivery to the macula densa, and the activity of the adrenergic nervous system. Other possible factors include circulating catecholamines, the serum and cerebrospinal fluid sodium concentration ...
A M, Chonko, J H, Stein, T F, Ferris
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Clinical and Experimental Pharmacology and Physiology, 1986
SUMMARY1. New gene data for three aspartyl proteases (human renin, mouse renin and human pepsin) permitted closer analysis of the gene duplication and fusion hypothesis for the evolution of this family of enzymes.2. Alignment of sequences in the hemilobes of human pepsin revealed only weak homology in amino acid sequences.
B J, Morris, D F, Catanzaro
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SUMMARY1. New gene data for three aspartyl proteases (human renin, mouse renin and human pepsin) permitted closer analysis of the gene duplication and fusion hypothesis for the evolution of this family of enzymes.2. Alignment of sequences in the hemilobes of human pepsin revealed only weak homology in amino acid sequences.
B J, Morris, D F, Catanzaro
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JAMA: The Journal of the American Medical Association, 1979
To the Editor.— The article by Laragh and associates inTHE JOURNAL(241:151, 1979) concerning renin profiling for the diagnosis and treatment of hypertensive patients puts the renin-angiotensin system in a unique position in regard to other humoral substances.
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To the Editor.— The article by Laragh and associates inTHE JOURNAL(241:151, 1979) concerning renin profiling for the diagnosis and treatment of hypertensive patients puts the renin-angiotensin system in a unique position in regard to other humoral substances.
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Cardiovascular Drugs and Therapy, 1995
Modification of the renin-angiotensin-aldosterone system by renin inhibitors may be an alternative to angiotensin-converting enzyme inhibitors in the treatment of cardiovascular disease. The development of clinically useful renin inhibitors has been hampered by a variety of pharmacologic problems, most notably the poor oral bioavailability of these ...
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Modification of the renin-angiotensin-aldosterone system by renin inhibitors may be an alternative to angiotensin-converting enzyme inhibitors in the treatment of cardiovascular disease. The development of clinically useful renin inhibitors has been hampered by a variety of pharmacologic problems, most notably the poor oral bioavailability of these ...
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American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2002
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Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System
Circulation Research, 2020Mahmoud Gheblawi +2 more
exaly
Extraction, Purification, and Assay of Human Renin Free of Angiotensinase
Circulation Research, 1966E Haas, Harry Goldblatt, H Goldblatt
exaly