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, 2015 Animal models have suggested a role of renin-angiotensin system (RAS) activation and subsequent cardiac oxidation in heart failure with preserved ejection fraction (HFpEF). Nevertheless, RAS blockade has failed to show efficacy in treatment of HFpEF.
EM Jeong (7930202) +9 more
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Diabetes, Metabolic Syndrome and ObesityMinmin Han,1,2,* Xiaoming Cao,3,* Jian Zhang,1,2 Xifeng Yang,1,2 Yi Zhang,4,5 Yunfeng Liu1,2 1Department of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, 030000, People’s Republic of China; 2First Clinical Medical College ...
Han M +5 more
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Spotlight on renin. Renin, prorenin and the putative (pro)renin receptor
Hypertension, 2005 Danser, Jan, Deinum, Jaap
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Renin report: spotlight on Renin: therapeutic opportunities for Renin inhibitors.
Journal of the renin-angiotensin-aldosterone system : JRAAS, 2006 openaire +1 more source
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Physiology, 2007
The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in salt, volume, and blood pressure homeostasis of the body. Renin is mainly produced and released into circulation by the so-called juxtaglomerular epithelioid cells, located in the walls of renal afferent arterioles at the ...
Schweda, Frank +4 more
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The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in salt, volume, and blood pressure homeostasis of the body. Renin is mainly produced and released into circulation by the so-called juxtaglomerular epithelioid cells, located in the walls of renal afferent arterioles at the ...
Schweda, Frank +4 more
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Renin Tachyphylaxis and ‘Renin Hypertension’ in the Rabbit
American Journal of Physiology-Legacy Content, 1956A ‘renin hypertension’ was produced by means of a constant intravenous infusion of a carefully quantitated renin solution. Renin injections were then superimposed to the point of tachyphylaxis. In all cases when tachyphylaxis was established, the blood pressure gradually returned to preinfusion levels.
S, SCHAPIRO, D B, GORDON, D R, DRURY
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[From the renin gene to renin inhibitors].
Annales d'endocrinologie, 1986The only known action of renin is the hydrolysis of angiotensinogen into angiotensin I. Renin is synthesized as an inactive precursor, preprorenin. The processing of prorenin into active renin occurs after the clivage of a profragment, just after a dibasic pair of amino-acids.
P, Corvol, J, Ménard
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The Nature of Renin Precursor and Inactive Renin
Clinical and Experimental Hypertension. Part A: Theory and Practice, 1982The biosynthesis of renin in the mouse submaxillary gland was defined using both cell-free translation and pulse-labelling methods. Renin is synthesized as a preproform and cleaved by microsomes to the proform. Prorenin (MW = 46 kilodaltons, pI 6.35) is processed intracellulary into an intermediate form (MW = 41 kilodaltons). The latter is converted by
V J, Dzau, A, Tanaka, R E, Pratt
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Inactive Renin — A Renin Proenzyme?
1977Human plasma contains an inactive form of renin with a m.w. of 55,000, as against around 40,000 for active human renin. After acidification to pH 3.0 or incubation with trypsin, the inactive renin becomes more active and the molecular weight falls to that of active renin.
B J, Leckie, A, McConnell, J, Jordan
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Is Angiotensinogen a Renin Inhibitor and Not the Substrate for Renin?
Journal of Hypertension, 1986The cleavage of the angiotensinogen molecule by renin is slow. The rate constant for cleavage of the enzyme-substrate complex, Kcat (turnover number) is lower than usual for enzymes (0.6/s for the homologous human renin reactions and 0.15/s for the homologous mouse renin reaction).
K, Poulsen, J, Jacobsen
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