Results 131 to 140 of about 163,477 (306)
Medicine Bulletin, EarlyView.Allisartan ranked best for serum urate reduction and showed favourable blood pressure control, whereas losartan also performed well overall. These rankings may inform ARB selection but should be interpreted cautiously because of inconsistency, heterogeneity and sparse direct evidence.
Xuanyao Li +5 more
wiley +1 more source
Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source
Medicine Advances, EarlyView.This article illustrates the current dilemmas of myocardial infarction patients after traditional cardiac rehabilitation, as well as the feasibility of using artificial intelligence to optimize and assist with rehabilitation programs such as by integrating mobile apps, wearables, ECGs, medication, vital signs, and assessment data; finally, the AI ...
Xinyuan Huang +6 more
wiley +1 more source
Diagnosis of Portal Hypertension: Advancing Towards Non‐Invasive Solutions
Portal Hypertension &Cirrhosis, EarlyView.This review systematically summarizes a full spectrum of non‐invasive diagnostic approaches for portal hypertension (PH), including imaging modalities, elastography, serum biomarkers, composite scoring systems and endoscopic ultrasound‐guided portal pressure gradient (EUS‐PPG), and analyzes their performance across different liver disease etiologies ...
Lijia Yin, Huikuan Chu, Ling Yang
wiley +1 more source
Precision Medical Sciences, EarlyView.Hyperglycemia‐driven cytokine activation initiates a sustained inflammatory cascade in diabetic kidney disease, promoting cellular injury and fibrogenic signaling. Integrating cytokine‐based biomarkers with risk stratification enables precision therapeutics that target inflammation and fibrosis, ultimately aiming to halt progression from early renal ...
Emmanuel Ifeanyi Obeagu
wiley +1 more source
Different Sides of Renin Angiotensin System [PDF]
, 2015 The main physiological role of the renin angiotensin system (RAS) is to regulate blood pressure and water balance. It contains a group of related hormones that act together and called as angiotensins, receptors and enzymes. This system plays an important
Yasemin Korkut +6 more
core
Phytotherapy Research, EarlyView.Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng +6 more
wiley +1 more source
Renin-Angiotensin-Aldosterone System Antagonism and Polycystic Kidney Disease Progression.
, 2016 Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a systemic disease characterised by the formation of multiple renal cysts that adversely affect renal function.
Chuan Kai Hian (7951946) +2 more
core +2 more sources
Phytotherapy Research, EarlyView.Schematic representation of the shared pathophysiological mechanisms underlying heart failure (HF) and atrial fibrillation (AF), including inflammation, oxidative stress, endothelial dysfunction, and fibrosis. The figure highlights the clinical and mechanistic convergence of conventional pharmacological therapies and selected nutraceuticals in ...
Laura Beatrice Mattioli +6 more
wiley +1 more source