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Blood Pressure, 2023 Purpose Primary aldosteronism (PA), characterised by low-renin hypertension, confers a high cardiovascular risk and is the most common cause of secondary hypertension, with an increased prevalence in patients with treatment-resistant hypertension ...
Christian Beger +6 more
doaj +1 more source
Aliskiren, enalapril, or aliskiren and enalapril in heart failure [PDF]
, 2016 BACKGROUND Among patients with chronic heart failure, angiotensin-converting–enzyme (ACE) inhibitors reduce mortality and hospitalization, but the role of a renin inhibitor in such patients is unknown.
] +15 more
core +5 more sources
The Nature of Renin Precursor and Inactive Renin
Clinical and Experimental Hypertension. Part A: Theory and Practice, 1982 The biosynthesis of renin in the mouse submaxillary gland was defined using both cell-free translation and pulse-labelling methods. Renin is synthesized as a preproform and cleaved by microsomes to the proform. Prorenin (MW = 46 kilodaltons, pI 6.35) is processed intracellulary into an intermediate form (MW = 41 kilodaltons). The latter is converted by
A Tanaka +2 more
openaire +3 more sources
Clinical and Experimental Hypertension, 2019 Ficus deltoidea is used in Malay traditional medicine for the treatment of a number of disorders, including hypertension. There is, however, no scientific evidence on its anti-hypertensive effects.
Mohd Saleh Ahmad Kamal +7 more
doaj +1 more source
Southern Clinics of Istanbul Eurasia, 2017 INTRODUCTION[|]To evaluate first trimester renin and aldosterone levels of pregnancies complicated with preeclampsia and/or related adverse pregnancy outcomes.[¤]METHODS[|]We measured serum levels of renin and aldosterone for pregnant women for first ...
Yunus Emre Purut +4 more
doaj +1 more source
Differential renal effects of candesartan at high-and ultra-high doses in diabetic mice: potential role of ACE2/AT2R/Mas [PDF]
, 2016 High doses of Ang II receptor (AT1R) blockers (ARBs) are renoprotective in diabetes. Underlying mechanisms remain unclear. We evaluated whether high/ultra-high doses of candesartan (ARB) up-regulate angiotensin-converting enzyme 2 (ACE2)/Ang II type 2 ...
Antunes, Tayze +10 more
core +1 more source
Emerging pharmacological treatments to prevent abdominal aortic aneurysm growth and rupture [PDF]
, 2015 Abdominal aortic aneurysm (AAA) is a local expansion of the abdominal aorta wall caused by a complex multifactorial maladaptive vascular remodeling. Despite recent advances in the management of cardiovascular diseases, there currently is no established ...
Fraga-Silva, Rodrigo +2 more
core +2 more sources
Cells, 2021 We investigated the expression of components of the renin-angiotensin system (RAS) by cancer stem cell (CSC) subpopulations in metastatic head and neck cutaneous squamous cell carcinoma (mHNcSCC).
Sam Siljee +9 more
doaj +1 more source
Current trends in single‐cell RNA sequencing applications in diabetes mellitus
FEBS Open Bio, EarlyView.Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian +6 more
wiley +1 more source
Aldosterone status associates with insulin resistance in patients with heart failure-data from the ALOFT study [PDF]
, 2009 <b>Background</b>: Aldosterone plays a key role in the pathophysiology of heart failure. In around 50% of such patients, aldosterone 'escapes' from inhibition by drugs that interrupt the renin-angiotensin axis; such patients have a worse ...
Connell, J.M.C. +8 more
core +1 more source