Results 31 to 40 of about 221,319 (346)

Renin and Renin Inhibition in Anephric Man

Clinical and Experimental Hypertension, 1993
Renin activity appears to be present in low concentrations in the plasma of anephric humans but could be artifactual secondary to inadvertent activation of prorenin during specimen collection and handling or from a renin-like enzyme. We studied the effects of specimen collection, storage, different assay conditions, trypsin activation, and the renin ...
Robert D. Murray, Stephen A. Katz, Paul A. Abraham, John A. Opsahl, Kevin L. Smith   +4 more
openaire   +3 more sources

Vitamin D alleviates lipopolysaccharide-induced acute lung injury via regulation of the renin-angiotensin system

Molecular Medicine Reports, 2017
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are the clinical manifestations of severe lung damage and respiratory failure. ALI and ARDS result are associated with high mortality in patients.
Jun Xu, Jialai Yang, Jian Chen, Qing-li Luo, Qiu Zhang, Hong Zhang   +5 more
semanticscholar   +1 more source

Kinetics of the inhibition of renin and angiotensin I-converting enzyme by cod (Gadus morhua) protein hydrolysates and their antihypertensive effects in spontaneously hypertensive rats

Food & Nutrition Research, 2015
Background: Cod muscle has a balanced protein profile that contains potentially bioactive amino acid sequences. However, there is limited information on release of these peptides from the parent proteins and their ability to modulate mammalian blood ...
Abraham T. Girgih, Ifeanyi D. Nwachukwu, Fida Hasan, Tayo N. Fagbemi, Tom Gill, Rotimi E. Aluko   +5 more
doaj   +1 more source

Relation of the renin–angiotensin–aldosterone system with potential cardiac injury and remodelling: the SABPA study

Blood Pressure, 2020
Purpose: The renin-angiotensin-aldosterone system (RAAS) plays an important role in maintaining hemodynamic homeostasis. Ethnic disparities exist regarding RAAS activity due to sympathetic activity and sodium-water retention, however the implications ...
Lebo F. Gafane-Matemane, Nametsegang L. Mokae, Yolandi Breet, Leone Malan   +3 more
doaj   +1 more source

Targeting the renin-angiotensin system to improve cancer treatment: Implications for immunotherapy

Science Translational Medicine, 2017
By reprogramming the tumor microenvironment, renin-angiotensin system inhibitors have the potential to increase effectiveness of immunotherapy. Renin-angiotensin system (RAS) inhibitors (RASi)—widely prescribed for the treatment of cardiovascular ...

semanticscholar   +1 more source

Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double‐Blind Randomized Controlled Trial

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundGuidelines for hypertension vary in their preference for initial combination therapy or initial monotherapy, stratified by patient profile; therefore, we compared the efficacy and tolerability of these approaches.
Thomas M. MacDonald, Bryan Williams, David J. Webb, Steve Morant, Mark Caulfield, J. Kennedy Cruickshank, Ian Ford, Peter Sever, Isla S. Mackenzie, Sandosh Padmanabhan, Gerald P. McCann, Jackie Salsbury, Gordon McInnes, Morris J. Brown   +13 more
doaj   +1 more source

The Nature of Renin Precursor and Inactive Renin

Clinical and Experimental Hypertension. Part A: Theory and Practice, 1982
The biosynthesis of renin in the mouse submaxillary gland was defined using both cell-free translation and pulse-labelling methods. Renin is synthesized as a preproform and cleaved by microsomes to the proform. Prorenin (MW = 46 kilodaltons, pI 6.35) is processed intracellulary into an intermediate form (MW = 41 kilodaltons). The latter is converted by
A Tanaka, Victor J. Dzau, Richard E. Pratt   +2 more
openaire   +3 more sources

Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin.

Journal of Clinical Investigation, 2002
Renin is an aspartyl protease essential for the control of blood pressure and was long suspected to have cellular receptors. We report the expression cloning of the human renin receptor complementary DNA encoding a 350-amino acid protein with a single ...
G. Nguyen, F. Delarue, C. Burcklé, L. Bouzhir, T. Giller, J. Sraer   +5 more
semanticscholar   +1 more source

Diagnosis and management of primary aldosteronism

Archives of Endocrinology and Metabolism
Primary aldosteronism (PA) is the most common form of secondary hypertension (HTN), with an estimated prevalence of 4% of hypertensive patients in primary care and around 10% of referred patients. Patients with PA have higher cardiovascular morbidity and
Leticia A. P. Vilela, Madson Q. Almeida
doaj   +1 more source

Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects.

Journal of Clinical Endocrinology and Metabolism, 1969
A radioimmunoassay for angiotensin I and its application to the determination of renin activity is described. The assay employs antibodies raised to copolymers of angiotensin I and succinylated poly-l-lysine. Angiotensin labeled with 125I and purified by
E. Haber, T. Koerner, L. B. Page, B. Kliman, A. Purnode   +4 more
semanticscholar   +1 more source