Robust Causal Inference of Drug-drug Interactions [PDF]
arXiv, 2022 There is growing interest in developing causal inference methods for multi-valued treatments with a focus on pairwise average treatment effects. Here we focus on a clinically important, yet less-studied estimand: causal drug-drug interactions (DDIs), which quantifies the degree to which the causal effect of drug A is altered by the presence versus the ...
arxiv
Effects of Circulating and Local Uteroplacental Angiotensin II in Rat Pregnancy. [PDF]
, 2010 The renin-angiotensin (Ang) system is important during placental development. Dysregulation of the renin-Ang system is important in preeclampsia (PE). Female rats transgenic for the human angiotensinogen gene crossed with males transgenic for the human ...
Brosnihan, KB +12 more
core +1 more source
Is Covid-19 severity associated with ACE2 degradation? [PDF]
arXiv, 2021 Covid-19 is particularly mild with children, and its severity escalates with age. Several theories have been proposed to explain these facts. In particular, it was proposed that the lower expression of the viral receptor ACE2 in children protects them from severe Covid.
arxiv
Localization of the succinate receptor in the distal nephron and its signaling in polarized MDCK cells [PDF]
, 2009 When the succinate receptor (SUCNR1) is activated in the afferent arterioles of the glomerulus it increases renin release and induces hypertension.
Deen +37 more
core +1 more source
An Epidemiological and Geospatial Study of Cardiometabolic Risk Factors in the Illawarra-Shoalhaven Region of NSW, Australia. [PDF]
, 2020 Introduction: Cardiovascular disease (CVD) associated metabolic risk factors are a growing human health concern in Australia and worldwide. This thesis investigated the small-area geographic variation in the distribution of cardiometabolic risk factors ...
Toms, Renin Melkias Baby Selvi
core +1 more source
Immunohistochemical expression of intrarenal renin angiotensin system components in response to tempol in rats fed a high salt diet [PDF]
, 2017 AIM:To determine the effect of tempol in normal rats fed high salt on arterial pressure and the balance between antagonist components of the renal renin-angiotensin system.METHODS:Sprague-Dawley rats were fed with 8% NaCl high-salt (HS) or 0.4% NaCl ...
Cao, Gabriel Fernando +7 more
core +1 more source
The associations of adipokines with selected markers of the renin-angiotensinogen-aldosterone system: the multi-ethnic study of atherosclerosis. [PDF]
, 2015 Among obese individuals, increased sympathetic nervous system (SNS) activity results in increased renin and aldosterone production, as well as renal tubular sodium reabsorption.
Allison, MA +4 more
core +3 more sources
Southern Clinics of Istanbul Eurasia, 2017 INTRODUCTION[|]To evaluate first trimester renin and aldosterone levels of pregnancies complicated with preeclampsia and/or related adverse pregnancy outcomes.[¤]METHODS[|]We measured serum levels of renin and aldosterone for pregnant women for first ...
Yunus Emre Purut +4 more
doaj +1 more source
Pharmacological effects of raas blockade in ischemic nephropathy [PDF]
, 2016 Background: The management of ischemic nephropathy due to atherosclerotic renal artery stenosis has become increasingly conservative in the modern era, with current guidelines recommending optimized medical therapy as the initial step.
Barbano, Biagio +8 more
core +1 more source
Clinical and Experimental Hypertension, 2019 Ficus deltoidea is used in Malay traditional medicine for the treatment of a number of disorders, including hypertension. There is, however, no scientific evidence on its anti-hypertensive effects.
Mohd Saleh Ahmad Kamal +7 more
doaj +1 more source