Results 41 to 50 of about 217,588 (352)
Robust Causal Inference of Drug-drug Interactions [PDF]
arXiv, 2022 There is growing interest in developing causal inference methods for multi-valued treatments with a focus on pairwise average treatment effects. Here we focus on a clinically important, yet less-studied estimand: causal drug-drug interactions (DDIs), which quantifies the degree to which the causal effect of drug A is altered by the presence versus the ...
arxiv
Pathological Hypertrophy and Cardiac Interstitium: Fibrosis and Renin‐Angiotensin‐Aldosterone System
Circulation, 1991 Left ventricular hypertrophy (LVH) is the major risk factor associated with myocardial failure. An explanation for why a presumptive adaptation such as LVH would prove pathological has been elusive.
K. Weber, C. Brilla
semanticscholar +1 more source
The Nature of Renin Precursor and Inactive Renin
Clinical and Experimental Hypertension. Part A: Theory and Practice, 1982 The biosynthesis of renin in the mouse submaxillary gland was defined using both cell-free translation and pulse-labelling methods. Renin is synthesized as a preproform and cleaved by microsomes to the proform. Prorenin (MW = 46 kilodaltons, pI 6.35) is processed intracellulary into an intermediate form (MW = 41 kilodaltons). The latter is converted by
A Tanaka +2 more
openaire +3 more sources
Diagnosis and management of primary aldosteronism
Archives of Endocrinology and MetabolismPrimary aldosteronism (PA) is the most common form of secondary hypertension (HTN), with an estimated prevalence of 4% of hypertensive patients in primary care and around 10% of referred patients. Patients with PA have higher cardiovascular morbidity and
Leticia A. P. Vilela, Madson Q. Almeida
doaj +1 more source
Is Covid-19 severity associated with ACE2 degradation? [PDF]
arXiv, 2021 Covid-19 is particularly mild with children, and its severity escalates with age. Several theories have been proposed to explain these facts. In particular, it was proposed that the lower expression of the viral receptor ACE2 in children protects them from severe Covid.
arxiv
Food & Nutrition Research, 2015 Background: Cod muscle has a balanced protein profile that contains potentially bioactive amino acid sequences. However, there is limited information on release of these peptides from the parent proteins and their ability to modulate mammalian blood ...
Abraham T. Girgih +5 more
doaj +1 more source
Journal of Clinical Investigation, 2002 Renin is an aspartyl protease essential for the control of blood pressure and was long suspected to have cellular receptors. We report the expression cloning of the human renin receptor complementary DNA encoding a 350-amino acid protein with a single ...
G. Nguyen +5 more
semanticscholar +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundGuidelines for hypertension vary in their preference for initial combination therapy or initial monotherapy, stratified by patient profile; therefore, we compared the efficacy and tolerability of these approaches.
Thomas M. MacDonald +13 more
doaj +1 more source
Journal of Clinical Endocrinology and Metabolism, 1969 A radioimmunoassay for angiotensin I and its application to the determination of renin activity is described. The assay employs antibodies raised to copolymers of angiotensin I and succinylated poly-l-lysine. Angiotensin labeled with 125I and purified by
E. Haber +4 more
semanticscholar +1 more source
International Journal of Food Properties, 2021 Sesame seed was defatted and subsequently fractionated into albumin, globulin, glutelin and prolamin. The defatted flour was also subjected to alkaline solubilization and acid precipitation to obtain protein isolate.
Atinuke O. Idowu +3 more
doaj +1 more source