Results 61 to 70 of about 163,477 (306)

Functional Relevancies of Trans-Differentiation in the Juxtaglomerular Apparatus of Rat Kidney

International Journal of Nephrology and Renovascular Disease, 2020
Zsolt Razga Department of Pathology, University of Szeged, Szeged, HungaryCorrespondence: Zsolt RazgaDepartment of Pathology, University of Szeged, Állomás U.
Razga Z
doaj  

Safety and pharmacokinetics of mosliciguat, a new, inhaled soluble guanylate cyclase activator, in healthy adult subjects

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mosliciguat (BAY 1237592), the first soluble guanylate cyclase (sGC) activator in a dry powder inhaler (DPI), could potentially treat pulmonary hypertension with a more targeted delivery than systemic sGC stimulators. We report safety and tolerability of mosliciguat in healthy men.
Johannes Nagelschmitz, Soundos Saleh, Sandra Ligges, Melanie Seidel‐Greven, Eva Becker‐Pelster, Sylvia M. Nikkho, Stefanie Boxnick, Wolfgang Timmer   +7 more
wiley   +1 more source

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

British Journal of Clinical Pharmacology, EarlyView.
Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activation of the renin–angiotensin–aldosterone system, sympathetic nervous system ...
Christina Antza, Andrej Belancic, Jens Jordan, Alberto Esteban, Anna Oliveras, Ryan McNally, Panagiota Anyfanti, Jorie Versmissen, María S. Fernández‐Alfonso, Vasilios Kotsis, Thomas Weber, Alexandre Persu, Reinhold Kreutz   +12 more
wiley   +1 more source

A Comparative Study on Inter and Intra-Laboratory Reproducibility of Renin Measurement with a Conventional Enzymatic Method and a New Chemiluminescent Assay of Immunoreactive Renin

, 2009
Background: The activity of the renin-angiotensin system is usually evaluated as plasma renin activity (PRA, ng AI/ml/h) but the interlaboratory reproducibility of this enzymatic assay is notoriously scarce.
A. Morganti, on behalf of the European Group for the Validation of the DiaSorin Liaison Direct Renin Assay   +1 more
core   +2 more sources

Renin-angiotensin-aldosteron system: evolution of views from renin discovery to nowadays. Perspectives of therapeutic block

Терапевтический архив, 2011
Recent revolution in the knowledge about structure, physiological and pathophysiological effects of renin-angiotensin-aldosteron system (RAAS) took place recently when it was discovered that local synthesis of all the RAAS components occurs in target ...
Marina Vladimirovna Shestakova, M V Shestakova   +1 more
doaj  

Temporal Trends and Prognosis in Rotational Atherectomy: A Comparison of Contemporary and Traditional Eras

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Rotational atherectomy (RA) has undergone considerable technical modernization in recent years. This study evaluated whether RA performed in the contemporary era was associated with superior cardiovascular outcomes compared with the traditional era. Aims To compare the clinical characteristics and cardiovascular outcomes of patients
Ravi Vazirani, Gonzalo García‐Martí, Andrés Provencio‐Regidor, Irene Serrano‐García, Adrián Jerónimo‐Baza, Alejandro Travieso, Gabriela Tirado‐Conte, Fernando Macaya‐Ten, Hernán Mejía‐Rentería, Pablo Salinas, Luis Nombela‐Franco, Pilar Jiménez‐Quevedo, Nieves Gonzalo, Javier Escaned, Antonio Fernández‐Ortiz, Iván J. Núñez‐Gil   +15 more
wiley   +1 more source

Remodeling of left ventricle in hypertensive patients with renal addition arteries: associations with renin level and glomerular filtration rate

Лечащий Врач, 2021
The article is devoted to analysis of relationship of left ventricular remodeling, plasma renin level, glomerular filtration rate in patients with arterial hypertension and renal additional arteries.
Yu. P. Red’ko, N. N. Gladkikh, A. V. Yagoda   +2 more
doaj  

Genetics and pathophysiology of low-renin arterial hypertension

Вавиловский журнал генетики и селекции, 2019
The review is devoted to the consideration of genetic determination and pathophysiology of one of the forms of hypertensive disease known as low-renin hypertension.
A. L. Markel
doaj   +1 more source

Clinical Impact of Adherence to Fractional Flow Reserve Guidance in Acute Coronary Syndrome

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Fractional flow reserve (FFR) is established to guide revascularization in stable coronary disease and non‐culprit lesions in acute coronary syndromes (ACS). However, real‐world adherence to FFR guidance across the spectrum of ACS presentations, including ambiguous culprit scenarios, remains incompletely characterized.
Eun Ho Choo, Ik Jun Choi, Sungmin Lim, Donggyu Moon, Dae‐Won Kim, Kiyuk Chang   +5 more
wiley   +1 more source

Renin-angiotensin system overactivation in polycystic ovary syndrome, a risk for SARS-CoV-2 infection?

, 2021
Background: The SARS-CoV-2 coronavirus gains entry to target cells via the angiotensin-converting enzyme 2 (ACE2) receptor present on cells in blood vessels, lungs, heart, intestines, and kidneys. Renin-Angiotensin System (RAS) overactivity has also been
Abu Saleh Md Moin (6189512), Stephen Atkin (12597178), Alexandra E Butler (4375915), Thozhukat Sathyapalan (704787)   +3 more
core   +3 more sources