Results 51 to 60 of about 261,257 (360)

Effectiveness of 2D fingerprints for scaffold hopping

, 2011
Background: It has been suggested that similarity searching using 2D fingerprints may not be suitable for scaffold hopping. Methods: This article reports a detailed evaluation of the effectiveness of six common types of 2D fingerprints when they are used
Gardiner, E.J., Holliday, J.D., O'Dowd, C., Willett, P.   +3 more
core   +1 more source

Temporal glomerular gene expression dynamics during disease progression in a mouse model of hypertension‐accelerated diabetic kidney disease

Animal Models and Experimental Medicine, EarlyView.
The current study characterized temporal changes in glomerular gene expression, pathology, and biomarkers in a mouse model of hypertension‐accelerated diabetic kidney disease (DKD). Progressive albuminuria and glomerulosclerosis were paralleled by dynamic transcriptomic changes associated withmetabolic dysfunction, extracellular matrix remodeling, and ...
Adam B. Marstrand‐Jørgensen, Frederikke Emilie Sembach, Maria Ougaard, Ditte Hansen, Mette Viberg Østergaard, Henrik H. Hansen, Louise S. Dalbøge, Ole Jørgen Kaasbøll, Michael Christensen   +8 more
wiley   +1 more source

Major Adverse Cardiovascular Events in Primary Aldosteronism After Adrenalectomy or Mineralocorticoid Receptor Antagonist Treatment: A Systematic Review and Meta‐Analysis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The object of this study was to investigate the incidence rate of major adverse cardiovascular event (MACE) among patients with primary aldosteronism (PA) after adrenalectomy or mineralocorticoid receptor antagonist (MRA) treatment.
Chien‐Wei Huang, Tse‐Ying Huang, Ya‐Fei Yang, Li‐Yang Chang, Yu‐Kang Tu, Vin‐Cent Wu, Jui‐Yi Chen   +6 more
doaj   +1 more source

Trends in 25 years of antihypertensive agent utilization in Croatia – an alert for scientific community and healthcare providers

British Journal of Clinical Pharmacology, EarlyView.
Aims Hypertension is a leading modifiable risk factor for cardiovascular mortality worldwide. This study aimed to evaluate 25‐year trends in antihypertensive agent (AHA) utilization in Croatia between 2000 and 2024. Methods We conducted a national, population‐based analysis using IMS and IQVIA pharmaceutical databases.
Andrej Belančić, Marta Kučan Štiglić, Ana Jelaković, Bojan Jelaković, Dinko Vitezić   +4 more
wiley   +1 more source

Aliskiren Attenuates the Inflammatory Response and Wound Healing Process in Diabetic Mice With Periodontal Disease

Frontiers in Pharmacology, 2019
The aim of this study was to characterize the role of local RAS (renin–angiotensin system) in the inflammatory response of normal (N) and diabetic (D) mice with periodontal disease (PD).
Sandra Helena Penha Oliveira, Sandra Helena Penha Oliveira, Victor Gustavo Balera Brito, Victor Gustavo Balera Brito, Sabrina Cruz Tfaile Frasnelli, Bianca da Silva Ribeiro, Milena Nunes Ferreira, Dayane Priscilla Queiroz, Dayane Priscilla Queiroz, Carluci Taís Beltan, Vanessa Soares Lara, Carlos Ferreira Santos   +11 more
doaj   +1 more source

Increased circulating ANG II and TNF-α represents important risk factors in obese Saudi adults with hypertension irrespective of diabetic status and BMI [PDF]

, 2012
Central adiposity is a significant determinant of obesity-related hypertension risk, which may arise due to the pathogenic inflammatory nature of the abdominal fat depot.
A Berrington de Gonzalez, A Harte, A Taube, AG Bertoni, Aimin Xu, Alison L. Harte, Amany O. Mohamed, AV Chobanian, B Chamarthi, BL Goodwin, BM Celoria, BM Cheung, C Asferg, C Asferg, C Savoia, D Gurantz, D Kalra, D Ma, ES Androulakis, F Galletti, F Galletti, G Mancia, H Itani, H Zhang, Hossam M. Draz, J Feber, J Liu, JD Fowler, JE Hall, JM do Carmo, JV Patel, K Ohashi, KF Adams, Khalid M. Alkharfy, L Alhyas, LE Bautista, Lotfi S. Bindahman, M Adamczak, M Carlyle, M Hernandez-Presa, M Pruijm, M Tohidi, M Vlasova, MA Al-Homrany, Majed S. Alokail, MY Baden, N Al-Daghri, Nasser M. Al-Daghri, NM Al-Daghri, NS Kalupahana, Omar S. Al-Attas, Philip G. McTernan, R Fogari, R Summer, RT Sabo, S Sriramula, S Yasue, Sobhy Yakout, T Wago, TA Kotchen, Tahia H. Saleem, X Gao, Y Deng, Y Takeshita   +63 more
core   +2 more sources

Renin and Renin Inhibition in Anephric Man

Clinical and Experimental Hypertension, 1993
Renin activity appears to be present in low concentrations in the plasma of anephric humans but could be artifactual secondary to inadvertent activation of prorenin during specimen collection and handling or from a renin-like enzyme. We studied the effects of specimen collection, storage, different assay conditions, trypsin activation, and the renin ...
J A, Opsahl, K L, Smith, R D, Murray, P A, Abraham, S A, Katz   +4 more
openaire   +2 more sources

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

The classical and alternative circulating renin‐angiotensin system in normal dogs and dogs with stage B1 and B2 myxomatous mitral valve disease [PDF]

, 2023
Hillary K. Hammond, Marisa K. Ames, Oliver Domenig, Brian A. Scansen, Nuen Tsang Yang, Machelle Wilson, Erin Sunshine, Kaitlyn Brunk, A Masters   +8 more
openalex   +1 more source

Angiotensinergic innervation of rat and human mesenteric resistant blood vessels [PDF]

, 2007
In contrast to the current believe that angiotensin II (Ang II) only interacts with the sympathetic nervous system (SNS) as a circulating hormone, we document here the existence of an endogenous renin-angiotensin system (RAS) in the sympathetic coeliac ...
Eva Heiniger, Hans Imboden, Jaspal Patil, Oliver Muhlemann, Thomas Schaffner   +4 more
core   +1 more source