Results 51 to 60 of about 217,588 (352)

Assessment of Anti-Hypertensive Drug Adherence by Serial Aldosterone-To-Renin Ratio Measurement

Frontiers in Pharmacology, 2021
Reduced or absent compliance to anti-hypertensive treatment is a major obstacle to the achievement of blood pressure target in patients with arterial hypertension.
Fabrizio Buffolo, Elisa Sconfienza, Jacopo Burrello, Isabel Losano, Giulio Mengozzi, Gabriella Priolo, Valeria Avataneo, Antonio D’Avolio, Franco Veglio, Franco Rabbia, Paolo Mulatero, Silvia Monticone   +11 more
doaj   +1 more source

Role of the Renin-Angiotensin-Aldosterone System beyond Blood Pressure Regulation: Molecular and Cellular Mechanisms Involved in End-Organ Damage during Arterial Hypertension

International Journal of Molecular Sciences, 2016
Arterial hypertension is a common condition worldwide and an important predictor of several complicated diseases. Arterial hypertension can be triggered by many factors, including physiological, genetic, and lifestyle causes.
N. Muñoz-Durango, Cristóbal A. Fuentes, Andrés E. Castillo, L. González-Gómez, A. Vecchiola, C. Fardella, A. Kalergis   +6 more
semanticscholar   +1 more source

Modeling the molecular impact of SARS-CoV-2 infection on the renin-angiotensin system [PDF]

arXiv, 2020
SARS-CoV-2 coronavirus infection is mediated by the binding of its spike protein to the angiotensin-converting enzyme 2 (ACE2), which plays a pivotal role in the renin-angiotensin system (RAS). The study of RAS dysregulation due to SARS-CoV-2 infection is fundamentally important for a better understanding of the pathogenic mechanisms and risk factors ...
arxiv  

Hypertension Renin–Angiotensin–Aldosterone System Alterations

, 2015
Blockers of the renin-angiotensin-aldosterone system (RAAS), that is, renin inhibitors, angiotensin (Ang)-converting enzyme (ACE) inhibitors, Ang II type 1 receptor antagonists, and mineralocorticoid receptor antagonists, are a cornerstone in the ...
L. Riet, J. Esch, A. Roks, A. H. Meiracker, A. Danser   +4 more
semanticscholar   +1 more source

Renin-Angiotensin System and Cardiovascular Functions

Arteriosclerosis, Thrombosis and Vascular Biology, 2018
The renin-angiotensin system plays critical roles in maintaining normal cardiovascular functions and contributes to a spectrum of cardiovascular diseases.
Chia-Hua Wu, S. Mohammadmoradi, Jeff Z. Chen, Hisashi Sawada, A. Daugherty, Hong S. Lu   +5 more
semanticscholar   +1 more source

Screening and Identification of Novel DNA Aptamer for Targeted Delivery to Injured Podocytes in Glomerular Diseases

Advanced Science, EarlyView.
This study develops RLS‐2, a high‐affinity aptamer that specifically targets injured podocytes, making it a promising candidate for targeted drug delivery. In vitro, RLS‐2 shows stability, specificity, efficient siRNA delivery via AsiCs, and uptake by podocytes.
Chao Zhou, Zhaofeng Luo, Zheng Zhang, Qing Ye, Dongjie Wang, Hanyan Meng, Jiayu Zhang, Shifan Zhu, Lidan Hu, Jianhua Mao   +9 more
wiley   +1 more source

Latent Adrenal Insufficiency: From Concept to Diagnosis

Frontiers in Endocrinology, 2021
Primary adrenal insufficiency (PAI) is a rare disease and potentially fatal if unrecognized. It is characterized by destruction of the adrenal cortex, most frequently of autoimmune origin, resulting in glucocorticoid, mineralocorticoid, and adrenal ...
Nada Younes, Isabelle Bourdeau, Andre Lacroix   +2 more
doaj   +1 more source

CNPY2 Aggravates Renal Tubular Cell Ferroptosis in Diabetic Nephropathy by Regulating PERK/ATF4/CHAC1 Pathway and MAM Integrity

Advanced Science, EarlyView.
Canopy FGF signaling regulator 2 (CNPY2) which is contributed to ERS is upregulated in the renal tubules of patients with diabetic nephropathy (DN). Mechanistically, CNPY2 may regulate ferroptosis and MAM integrity in renal tubular epithelial cells through PERK/ATF4/CHAC1 pathway, thereby promoting the progression of DN.
Jingfang Chen, Dongwei Liu, Lei Lei, Ting Liu, Shaokang Pan, Hui Wang, Yong Liu, Yingjin Qiao, Zhangsuo Liu, Qi Feng   +9 more
wiley   +1 more source

Functional Relevancies of Trans-Differentiation in the Juxtaglomerular Apparatus of Rat Kidney

International Journal of Nephrology and Renovascular Disease, 2020
Zsolt Razga Department of Pathology, University of Szeged, Szeged, HungaryCorrespondence: Zsolt RazgaDepartment of Pathology, University of Szeged, Állomás U.
Razga Z
doaj  

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

Proceedings of the National Academy of Sciences of the United States of America, 2013
Olfactory receptors are G protein-coupled receptors that mediate olfactory chemosensation and serve as chemosensors in other tissues. We find that Olfr78, an olfactory receptor expressed in the kidney, responds to short chain fatty acids (SCFAs).
J. Pluznick, Ryan J. Protzko, Haykanush Gevorgyan, Z. Peterlin, A. Sipos, Jinah Han, Isabelle Brunet, Laxiang Wan, F. Rey, Tong Wang, S. Firestein, M. Yanagisawa, J. Gordon, A. Eichmann, J. Peti-Peterdi, M. Caplan   +15 more
semanticscholar   +1 more source