Results 111 to 120 of about 756,250 (282)

Renin inhibitors are a new direction in the treatment of arterial hypertension

Терапевтический архив, 2010
The paper covers current problems in the treatment of arterial hypertension. Renin is an important and promising therapeutic target. The direct renin inhibitor aliskiren (Rasilez) is a promising current effective antihypertensive agent that has cardio ...
Yuriy Aleksandrovich Vasyuk, Irina Akhmedkhanovna Sadulaeva, Elena Nikolaevna Yushchuk, Ol'ga Sergeevna Trofimenko, Mikhail Vasil'evich Chirkov, Viktoriya Sergeevna Fedoseeva, Kirill Georgievich Kulikov, Yu A Vasyuk, I A Sadulayeva, E N Yushchuk, O S Trofimenko, M V Chirkov, V S Fedoseyeva, K G Kulikov   +13 more
doaj  

Renin inhibitors versus angiotensin converting enzyme (ACE) inhibitors for primary hypertension. [PDF]

Cochrane Database Syst Rev, 2020
Wang GM, Li LJ, Tang WL, Wright JM.
europepmc   +1 more source

Multi‐Target Pharmacological Mechanisms of Salvia miltiorrhiza Bunge in Metabolic Syndrome and Cardiovascular Diseases: A Comprehensive Review Based on the Theory of “Same Treatment for Different Diseases”

Phytotherapy Research, EarlyView.
Salvia miltiorrhiza Bunge in metabolic syndrome and cardiovascular diseases: multi‐target actions on shared signaling pathways. ABSTRACT Metabolic syndrome (MetS) represents a clinical disorder characterized by the clustering of conditions including obesity, elevated blood sugar levels, and high lipid levels, which are intricately linked to the onset ...
Zhiyi Jia, Kaiyi Wu, Jiaying Qi, Nana Huang, Yusheng Liu, Xiumei Gao, Rong Sun   +6 more
wiley   +1 more source

Decades-old renin inhibitors are still struggling to find a niche in antihypertensive therapy. A fleeting look at the old and the promising new molecules. [PDF]

Bioorg Med Chem, 2020
Ramya K, Suresh R, Kumar HY, Kumar BRP, Murthy NBS.   +4 more
europepmc   +1 more source

Astragaloside IV Restores Autophagy and Inhibits Apoptosis for Podocyte Protection in Diabetic Nephropathy by Inhibiting Notch1 Signaling via SIRT6‐Mediated Deacetylation

Phytotherapy Research, EarlyView.
AS‐IV binds to SIRT6 and promotes H3K9 deacetylation at the Notch1 promoter, inhibiting gene transcription (Created with BioGDP.com). ABSTRACT Astragaloside IV (AS‐IV) has demonstrated efficacy in ameliorating proteinuria and attenuating renal tubular damage in preclinical diabetic nephropathy (DN) models.
Qiyu Yue, Chen Yong, Xinran Wang, Yang Shu, Min Yao, Yongfei Yu, Yubai Xue, Rong Deng, Tianlu Chu, Weiwei Tao, Min Zhao, Enchao Zhou   +11 more
wiley   +1 more source

Development, evaluation and application of 3D QSAR Pharmacophore model in the discovery of potential human renin inhibitors

BMC Bioinformatics, 2011
Background Renin has become an attractive target in controlling hypertension because of the high specificity towards its only substrate, angiotensinogen.
John Shalini, Thangapandian Sundarapandian, Arooj Mahreen, Hong Jong, Kim Kwang, Lee Keun   +5 more
doaj   +1 more source

Butein Attenuates Cardiac Hypertrophy by Restoring Redox–Mitochondrial Homeostasis Through Nrf2–Sirt3 Signaling

Phytotherapy Research, EarlyView.
Butein attenuates pathological cardiac hypertrophy by activating Nrf2–Sirt3 signaling, restoring mitochondrial function and redox homeostasis. ABSTRACT Butein (3,4,2′,4′‐tetrahydroxychalcone) is a bioactive chalcone with antioxidant, anti‐inflammatory, and cytoprotective properties.
Tsendsuren Tungalag, Dong Kwon Yang
wiley   +1 more source

Income‐Level and Immigrant Status Are Associated With Discontinuation of Evidence‐Based Secondary Prevention Therapies After Myocardial Infarction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Mechanisms for worse prognosis after myocardial infarction in low socioeconomic status are unclear. We therefore investigated the association between socioeconomic status and discontinuation of evidence‐based secondary prevention drug ...
Joel Ohm, Kevin Ma, Sara Freyland, Ali Yari, Tomas Jernberg, Per Svensson   +5 more
doaj   +1 more source

Renin Inhibitors [PDF]

New England Journal of Medicine, 1978
openaire   +4 more sources

Comparison of different drug interference with the renin-angiotensin system

, 1985
The hypotensive effects of inhibitors of renin or converting-enzyme (CE) were compared in normotensive sodium-depleted marmosets. Renin was inhibited by an antiserum or a monoclonal antibody against human kidney renin or by peptidic renin inhibitors. The
Fuhrer, W., Hofbauer, K. G., Wood, J. M., Heusser, C.   +3 more
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