Results 121 to 130 of about 3,459,561 (335)

The in vivo characterisation of a C-domain specific ACE inhibitor

, 2013
Includes bibliographical references.The ACE protein is a zinc-dependent dipeptidyl carboxypeptidase comprised of two homologous domains termed the C- and N-domain.
Sharp, Sarah-Kate
core  

Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin

, 2000
Background: The aspartic proteinase renin plays an important physiological role in the regulation of blood pressure. It catalyses the first step in the conversion of angiotensinogen to the hormone angiotensin II. In the past, potent peptide inhibitors of
Göschke, R, Grütter, MG, R Göschke, S Stutz, Maibaum, J, N-C Cohen, Fuhrer, W, H Rüeger, J Rahuel, Rüeger, H, Rasetti, V, W Fuhrer, Cohen, N-C, Cumin, F, F Cumin, V Rasetti, Stutz, S, JM Wood, MG Grütter, Wood, JM, Rahuel, J, J Maibaum   +21 more
core   +1 more source

Angiotensin-converting-enzyme gene insertion-deletion polymorphism and renin angiotensin aldosterone system activity in different phenotypes of polycystic ovary syndrome

Heliyon
Polycystic ovary syndrome (PCOS) is a common condition. Its pathophysiology involves an interaction between genetic and environmental factors, resulting in different reproductive and metabolic subtypes.
Khansa Chaabouni, Amana Saadallah-Kallel, Samia Ben Brahim, Kais Chaabane, Madiha Frikha, Mouna Mnif, Leila Keskes, Fatma Abdelhedi, Fatma Ayadi   +8 more
doaj   +1 more source

Donkwa Enriched With Goron‐Tula (Azanza garckeana) Modulates Sexual Behavior and Activity of Enzymes Linked With Erectile Dysfunction in High‐Fat Diets/ Streptozotocin‐Induced (STZ/HFD) Diabetic Rats

Food Chemistry International, EarlyView.
(A) Mount number, (B) mount latency, (C) intromission number, and (D) intromission latency are the parameters of sexual behavior. Met = metformin. D100 = 100 Donkwa. D90G10 = 90% Donkwa + 10% Goron‐Tula. D85G15 = 85% Donkwa + 15% Goron‐Tula. D80G20 = 80% Donkwa + 20% Goron‐Tula. The mean ± standard error of the mean (SEM) expressed the results. *Values
O. T. Mamukuyomi, O. S. Ijarotimi, A. A. Badejo   +2 more
wiley   +1 more source

The Role of Direct Renin Inhibitors in Clinical Practice

, 2018
Aliskiren is the only FDA approved direct renin inhibitor. It is generally accepted as an antihypertensive agent but it is mostly regarded as a third-line agent in the treatment of hypertension.
Adeyanju, Adedamola Abimbola
core  

Concomitant calcium entry blockade and inhibition of the renin-angiotensin system: a rational and effective means for treating hypertension

, 2008
Pharmacological treatment of hypertension is effective in preventing cardiovascular and renal complications. Calcium antagonists (CAs) and blockers of the renin-angiotensin system [angiotensin-converting enzyme (ACE) inhibitors and angiotensin II ...
Gojanovic, B., Feihl, F., Liaudet, L., Waeber, B.   +3 more
core   +1 more source

Rewiring nutrition: Chemical insights into the physiological and microbiological roles of food's microconstituents

Food Biomacromolecules, EarlyView.
Bidirectional interactions between food‐derived sensory compounds, gut sensing and microbiota, host physiological feedback, and metabolite production within the food matrix collectively shape sensory perception, microbial dynamics, and metabolic health.
Mohammad Nazrul Islam Bhuiyan
wiley   +1 more source

Renin inhibitors as possible antihypertensive agents

, 1988
The blockade of the renin-angiotensin system by inhibition of angiotensin-converting enzyme has become an established principle in the treatment of hypertension.
Hofbauer, K. G., Wood, J. M.
core  

SARS-CoV2: should inhibitors of the renin–angiotensin system be withdrawn in patients with COVID-19?

European Heart Journal, 2020
G. Kuster, O. Pfister, T. Burkard, Qian Zhou, R. Twerenbold, P. Haaf, A. Widmer, S. Osswald   +7 more
semanticscholar   +1 more source

Food‐grade proteins, lipids, and fibers as potential tools to ameliorate cardiovascular disorders: A review

Food Biomacromolecules, EarlyView.
Abstract Cardiovascular diseases (CVDs) remain the leading cause of global mortality, necessitating effective preventive and adjunct therapeutic strategies beyond conventional pharmacological interventions. Although previous reviews have focused on individual nutrients or dietary patterns, this review provides a mechanism‐based, integrative perspective
Sridevi Shanmugam, Rukaiah Fatma Begum, Nirenjen Shanmugasundaram, Bhupendra Gopalbhai Prajapati, Suresh Ankul Singh, Pavithra Nagenthran, Sudarshan Singh, Kesarla Rajesh   +7 more
wiley   +1 more source