Results 121 to 130 of about 756,250 (282)
BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.ABSTRACT Objective To analyse prescribing trends for oral and transdermal hormone replacement therapy (HRT) in Wales from 1996 to 2023, including predictors of discontinuation within one year of initiation. Design Observational study using the Secure Anonymised Information Linkage (SAIL) databank.
Robin Andrews +3 more
wiley +1 more source
Andrology, EarlyView.ABSTRACT Background Although the association between erectile dysfunction (ED) and cardiovascular disease is well established, its prevalence in patients with atherosclerosis remains poorly defined. Objectives To evaluate ED prevalence, severity, and associated risk factors (RFs) in patients with atherosclerotic disease.
Luca Farchioni +8 more
wiley +1 more source
Alimentary Pharmacology &Therapeutics, EarlyView.Commonly prescribed NSAIDs, PPIs and SSRIs were associated with a higher risk of microscopic colitis after propensity score matching, whereas ACE inhibitors, ARBs and statins showed no significant association. ABSTRACT Background The association between medications—including non‐steroidal anti‐inflammatory drugs (NSAIDs), proton pump inhibitors (PPIs ...
Yassine Kilani +6 more
wiley +1 more source
, 2009 Background: The activity of the renin-angiotensin system is usually evaluated as plasma renin activity (PRA, ng AI/ml/h) but the interlaboratory reproducibility of this enzymatic assay is notoriously scarce.
A. Morganti +1 more
core +1 more source
British Journal of Pharmacology, EarlyView.Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley +1 more source
Renin-Angiotensin System Inhibitor Use and Cancer Incidence Among UK Biobank Participants: A Prospective Cohort Study. [PDF]
Cancer MedABSTRACT Background Renin‐angiotensin system (RAS) inhibitors may influence cancer incidence, but previous findings have been inconsistent. We aimed to evaluate the associations of RAS inhibitor use with overall and site‐specific cancer incidence. Materials and Methods Participants receiving antihypertensive treatment without prior invasive cancer ...
Shi X +6 more
europepmc +2 more sources
Novel angiotensin II inhibitors in cardiovascular medicine.
, 2001 Blockade of the renin-angiotensin-aldosterone cascade is now recognised as a very effective approach to treat hypertensive, heart failure and high cardiovascular risk patients and to retard the development of renal failure.
Burnier, M., Burnier M
core +1 more source
A comprehensive review of cancer‐induced cardiac wasting
British Journal of Pharmacology, EarlyView.Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural cardiac remodelling, impaired contractile function and the development of ...
Alessia Lena +5 more
wiley +1 more source
Role of Vascular Wall Renin: Intracellular and Extracellular Mechanism
, 1991 Inhibitors of angiotensin-converting enzyme, renin and angiotensin II receptor lower the blood pressure of spontaneously hypertensive rats (SHRs) used as a model of essential hypertension.
Tetsuo Murakami +3 more
core +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Aldosterone plays a key role in blood pressure and volume regulation. Enhanced aldosterone secretion contributes to cardiovascular and renal diseases. Therefore, inhibitors of aldosterone receptors and synthase are essential drugs for the treatment of hypertension and heart failure.
Sanika Mohagaonkar +6 more
wiley +1 more source